Tag: M.W=400-500

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 446292-08-6, name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, This compound has unique chemical properties. The synthetic route is as follows., Formula: C22H19N3O6

S5, At room temperature 2-[[(S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidine-5-yl]methyl]- 1H-isoindole-1,3(2H)-dione(69.9 g, 0.165 mol) Obtained in step S4 was added to ethanol (1 L),80% hydrazine hydrate (0.044 g, 0.908 mmol) was added dropwise, and the mixture was heated to reflux for 2 h, then cooled to room temperature. The solvent was evaporated under reduced pressure. Water (1L) was evaporated. It was dried over anhydrous sodium sulfate, suction filtered, and then evaporated.The obtained residue was dried under reduced pressure to give a white solid(50.5g, 95.6%); Mp 149 ~ 152 C, [alpha]D25-42.6(c 0.1,DMSO) Chiral purity was 99.9% (HPLC normalization).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 446292-08-6.

Reference:
Patent; Suzhou Zhonglian Chemical Pharmaceutical Co., Ltd.; Zhou Zijin; Chen Feng; Luo Xinzu; Huang Junhao; (10 pag.)CN108690010; (2018); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Electric Literature of 446292-08-6,Some common heterocyclic compound, 446292-08-6, name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, molecular formula is C22H19N3O6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 2000 ml 4 neck RBF, charge Isopropanol (1000 ml), Methyl amine 33% solution in methanol (1000 ml) and 100 gms compound (III). Stirr the reaction mass at 55-60C for 5 hrs. Cool the reaction mass at 25-30C and stirr for 1 hr. Filter the reaction mass and wash with Isopropanol (50 ml). Dry the solid at 45-50C under vacuum. Dry Wt: 55 gms (Theoretical yield: 79.60%); Purity: 97.70%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, its application will become more common.

Reference:
Patent; MEHTA API PVT. LTD.; KHAN, Rao, Uwais, Ahmad; SONI, Amit Manohar; MALI, Sanjay, Gunda; (29 pag.)WO2016/199027; (2016); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Electric Literature of 446292-08-6,Some common heterocyclic compound, 446292-08-6, name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, molecular formula is C22H19N3O6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(1) 40 g of the compound of Formula 4 and 200 mL of ethanol are mixed at room temperature.Stir at room temperature. The temperature was raised to 40 C., a 200 mL aqueous solution of 12.0 potassium sulfide was dropped at 60 C. or lower, and the reaction was carried out at 40 to 40 C. for 4 to 5 hours. After 50 C, vacuum concentration to 150 ~ 200mL, 0 ~ 10 C stirring for 2 hours,Filtration and drying gave 26.3 g of a dry product of the compound of formula 3 in a yield of 95%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, its application will become more common.

Reference:
Patent; Zhejiang Mei Nuohua Pharmaceutical Chemical Co., Ltd.; Liu Xiong; Huang Xiangliang; Cao Qian; Chen Weiren; Yao Chengzhi; Zeng Wei; (9 pag.)CN107936006; (2018); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Adding a certain compound to certain chemical reactions, such as: 446292-08-6, name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 446292-08-6, Application In Synthesis of (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione

In a four neck round bottom flask, charged methanol (2900 ml), 2-([(5S)-2- Oxo-3-[4-(3-oxo- 4-morpholinyl)phenyl]-l,3-oxazolidin-5-yl}methyl)-lH-isoindole-l,3(2H)-dione (290 g), and 40% aqueous methylamine (265 g) at 25 to 30C. Reaction mass is stirred for 1 h at 25 to 30C and then heated to 60 to 65C, and maintained at same temperature for 4 h. Reaction mixture then cooled to 25 to 30C and added cone, hydrochloric acid (290 ml, pH should be 1 to 2) and stirred for 30 minutes. Obtained solid is filtered off and washed by chilled methanol (290ml). Yield= 92.0%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; WANBURY LTD.; DR. NITIN SHARADCHANDRA PRADHAN; DR. NILESH SUDHIR PATIL; DR. RAJESH RAMCHANDRA WALAVALKAR; MR. NILESH SUBHAS KULKARNI; MR. SANDIP BABANRAO PAWAR; MR. TARAK SAMBHAJI PAWAR; WO2014/102820; (2014); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 446292-08-6, Name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, SMILES is O=C1N(C[C@H]2CN(C3=CC=C(N4C(COCC4)=O)C=C3)C(O2)=O)C(C5=C1C=CC=C5)=O, belongs to indolines-derivatives compound. In a document, author is Meng, Shan-Shui, introduce the new discover, Application In Synthesis of (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione.

Computational Design of Enhanced Enantioselectivity in Chiral Phosphoric Acid-Catalyzed Oxidative Desymmetrization of 1,3-Diol Acetals

A general method for the highly enantioselective desymmetrization of 2-alkyl-substituted 1,3-diols is presented. A combination of computational and experimental studies has been utilized to understand the origin of the stereocontrol of oxidative desymmetrization of 1,3-diol benzylideneacetals. DFT calculations demonstrate that the acetal protecting group is highly influential for high enantioselectivity, and a simple but effective new protecting group has been designed. The desymmetrization reactions proceed with high enantioselectivity for a variety of substrates. Moreover, the reaction conditions are also shown to be effective for desymmetrization of 2,2-dialkyl-substituted 1,3-diols, which provides chiral products bearing acyclic all-carbon quaternary stereocenters. The method has been applied to the formal synthesis of indoline alkaloids.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 446292-08-6 is helpful to your research. Application In Synthesis of (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione.

In an article, author is Novotortsev, Vladimir K., once mentioned the application of 446292-08-6, Recommanded Product: (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, Name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, molecular formula is C22H19N3O6, molecular weight is 421.4, MDL number is MFCD11977665, category is indolines-derivatives. Now introduce a scientific discovery about this category.

New spiro-linked indolinone pyrrolidine selenoxoimidazolones

New 2-selenoxodispiro[imidazolidine-4,3′-pyrrolidine-4′,3 ”-indoline]-2 ”,5-dione system was accessed by addition of azomethine ylide at the double bond of (Z)-(2-oxoindolin-3-ylidene)-2-selenoxoimidazolidin-4-one derivatives. The latter were stereoselectively obtained in two steps from ethyl isoselenocyanatoacetate and isatins.

If you are interested in 446292-08-6, you can contact me at any time and look forward to more communication. Recommanded Product: (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione.

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Gohain, Shivanee Borpatra, once mentioned the application of 446292-08-6, Name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, molecular formula is C22H19N3O6, molecular weight is 421.4, MDL number is MFCD11977665, category is indolines-derivatives. Now introduce a scientific discovery about this category, SDS of cas: 446292-08-6.

Nano Au/Pd-catalysed ‘on-water’ synthesis of C3-C3 ‘ diaryl-oxindole scaffolds via N-2-selective dearomatization of indole

‘On-water’ synthesis of 2,2-bis(indoly-3-yl)indoline-3-ones via N-2-selective dearomatization of ‘(N-H) protection-free’ indole derivatives is described. An oxidative homo trimerization of indole via nano Au/Pd catalysis with oxone as additive was successfully demonstrated for the first time. In situ generation of isatin at room temperature and with water as solvent are key features.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 446292-08-6, SDS of cas: 446292-08-6.

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Name: (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, 446292-08-6, Name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, molecular formula is C22H19N3O6, belongs to indolines-derivatives compound. In a document, author is Ryzhkov, Fedor, V, introduce the new discover.

Stereoselective domino assembling of five molecules: one-pot approach to (2 ‘ R*, 3S*, 4 ‘ R*)-2 ‘, 4 ‘-diaryl-1 ‘,4 ‘-dihydro-2 ‘ H- Spiro[indoline-3, 3 ‘-pyridines]

A new stereoselective multicomponent reaction has been found: domino assembling of two equivalents of benzaldehyde, malononitrile, oxindole and excess of ammonium acetate in acetonitrile resulted in the formation of previously unknown (2’R*, 3S*,4’R*)-6′-amino-2-oxo-2′,4′-diaryl-1′,4′-dihydro-2’H-spiro lindoline-3,3′-pyridine]-5’-carbonitriles. Optimized reaction conditions and a mechanistic rationale for this multicomponent transformation are presented. This complex one-pot process occurs under mild conditions. The final compounds need no labor-intensive purification. [GRAPHICS] .

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 446292-08-6. Name: (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione.

In an article, author is Mikhailov, Maxim S., once mentioned the application of 446292-08-6, Computed Properties of C22H19N3O6, Name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, molecular formula is C22H19N3O6, molecular weight is 421.4, MDL number is MFCD11977665, category is indolines-derivatives. Now introduce a scientific discovery about this category.

9-(p-Tolyl)-2,3,4,4a,9,9a-hexahydro-1H-carbazole-A new donor building-block in the design of sensitizers for dye-sensitized solar cells

The novel donor building-block – 9-(p-tolyl)-2,3,4,4a,9,9a-hexahydro-1H-carbazole was designed and employed in the synthesis of dye-sensitized solar cell (DSSCs). An effective, high-yielding synthesis of 4,6-(4,4,5,5-tetramethy1-1,3,2-dioxaborolan-2-yl)-9-(p-tolyl)-1,2,3,4,4a,9a-hexahydrocarbazole from 1,2,3,4,4a,9a-hexahydrocarbazole was realized. Three new metal-free organic sensitizers, containing the new donor building block were prepared by a stepwise approach from 4,7-dibromobenzo[c][1,2,5]chacogenadiazoles. A 2,1,3-Benzothiadiazole dye containing hexahydrocarbazole donor, thiophene as pi-spacer and cyanoacrylate as anchoring electron acceptor showed photovoltaic properties higher than the well-known WS-2 sensitizer with PCE = 5.86 %. Although benzoxa- and -selenadiazole dyes have a bathochromic shift (24 – 30 nm) in the UV-vis spectra, and smaller energy gap E-g (about 0.1 eV), they have lower photovoltaic parameters, including PCE of 1.5-2.3 %. Introducing a new donor 9-(p-tolyl)-2,3,4,4a,9,9a-hexahydro-1H-carbazole into the construction of the DSSCs has broadened possibilities for the optimization of their photovoltaic properties.

If you are interested in 446292-08-6, you can contact me at any time and look forward to more communication. Computed Properties of C22H19N3O6.

446292-08-6, Name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, molecular formula is C22H19N3O6, Name: (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, is a common compound. In a patnet, author is Jana, Batakrishna, once mentioned the new application about 446292-08-6.

Self-Assembly of Mitochondria-Targeted Photosensitizer to Increase Photostability and Photodynamic Therapeutic Efficacy in Hypoxia

The development of photosensitizers for cancer photodynamic therapy has been challenging due to their low photostability and therapeutic inefficacy in hypoxic tumor microenvironments. To overcome these issues, we have developed a mitochondria-targeted photosensitizer consisting of an indocyanine moiety with triphenylphosphonium arms, which can self-assemble into spherical micelles directed to mitochondria. Self-assembly of the photosensitizer resulted in a higher photostability by preventing free rotation of the indoline ring of the indocyanine moiety. The mitochondria targeting capability of the photosensitizer allowed it to utilize intramitochondrial oxygen. We found that the mitochondria-targeted photosensitizer localized to mitochondria and induced apoptosis of cancer cells both normoxic and hypoxic conditions through generation of ROS. The micellar self-assemblies of the photosensitizer were further confirmed to selectively localize to tumor tissues in a xenograft tumor mouse model through passive targeting and showed efficient tumor growth inhibition.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 446292-08-6 help many people in the next few years. Name: (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione.