Indolines-derivatives

In 2020.0 ORG LETT published article about DIRECT ARYLATION; BITHIOPHENE COPOLYMERS; CONJUGATED POLYMER; HIGH-PERFORMANCE; MATERIALS DESIGN; CONVERSION in [Nitti, Andrea; Osw, Peshawa; Calcagno, Giuseppe; Pasini, Dario] Univ Pavia, Dept Chem, I-27100 Pavia, Italy; [Nitti, Andrea; Pasini, Dario] Univ Pavia, INSTM Res Unit, I-27100 Pavia, Italy; [Osw, Peshawa] Salahaddin Univ, Coll Sci, Dept Chem, Erbil 44001, Kurdistan, Iraq; [Botta, Chiara] CNR, Ist Studio Macromol ISMAC, I-20133 Milan, Italy; [Etkind, Samuel I.; Swager, Timothy M.] MIT, Dept Chem, Cambridge, MA 02139 USA; [Bianchi, Gabriele; Po, Riccardo] Ist Donegani SpA, Res Ctr Renewable Energies & Environm, I-28100 Novara, Italy in 2020.0, Cited 43.0. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3. Recommanded Product: Indolin-2-one

We demonstrate the broad applicability of the annulation protocol combining, in one pot, a direct arylation and cross aldol condensation for the straightforward synthesis at gram-scale of pi-extended thiophene-based scaffolds. The regiospecific direct arylation drives the subsequent cross-aldol condensation proceed under the same basic conditions, and the overall protocol has broad applicability in the synthesis of extended aromatics wherein the thiophene ring is annulated with furans, pyridines, indoles, benzothiophenes, and benzofurans. These scaffolds can be further elaborated into pi-extended, highly fluorescent oligomers with a central deficient benzothiadiazole unit with up to nine aromatic rings through coupling reactions.

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Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Authors Liu, CY; Li, ZY; Weng, ZY; Fang, XY; Zhao, F; Tang, KH; Chen, JY; Ma, WB in WILEY-V C H VERLAG GMBH published article about S BOND FORMATION; CATALYZED C-S; SULFONYL CHLORIDES; SULFENYLATION; SULFUR; ENAMINONES; FUNCTIONALIZATION; THIOPHENOLS; SULFIDES; INDOLES in [Liu, Changying; Li, Zheyu; Weng, Zhengyun; Fang, Xinyue; Zhao, Fei; Tang, Kehui; Ma, Wenbo] Chengdu Univ, Sichuan Ind Inst Antibiot, Antibiot Res & Reevaluat Key Lab Sichuan Prov, Huaguan Rd 168, Chengdu 610052, Peoples R China; [Chen, Jianyang] Chongqing Univ Arts & Sci, Coll Chem & Environm Engn, 319 Honghe Ave, Chongqing, Peoples R China in 2020.0, Cited 60.0. Safety of Indolin-2-one. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3

A synthetic method for the preparation of unsymmetrical 2-arylthioacetamides though direct C(sp(3))-H thiolation of arylacetamides with readily available substituted thiols, sulfenylchlorides and disulfides have been developed. Our strategy features a green reaction medium with ample substrate scope, affording the mono-thiolated aryl acetic acid derivatives in moderate to good yields in the presence of weak bases without any transition-metal catalyst.

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Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Product Details of 59-48-3. Alkayal, A; Tabas, V; Montanaro, S; Wright, IA; Malkov, AV; Buckley, BR in [Alkayal, Anas; Tabas, Volodymyr; Montanaro, Stephanie; Wright, Iain A.; Malkov, Andrei V.; Buckley, Benjamin R.] Loughborough Univ, Sch Sci, Dept Chem, Loughborough LE11 3TU, Leics, England published Harnessing Applied Potential: Selective beta-Hydrocarboxylation of Substituted Olefins in 2020, Cited 31. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3.

The construction of carboxylic acid compounds in a selective fashion from low value materials such as alkenes remains a long-standing challenge to synthetic chemists. In particular, beta-addition to styrenes is underdeveloped. Herein we report a new electrosynthetic approach to the selective hydrocarboxylation of alkenes that overcomes the limitations of current transition metal and photochemical approaches. The reported method allows unprecedented direct access to carboxylic acids derived from beta,beta-trisubstituted alkenes, in a highly regioselective manner.

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Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

An article Phosphine-Catalyzed Remote 1,7-Addition for Synthesis of Diene Carboxylates WOS:000526394500004 published article about GAMMA-SUBSTITUTED ALLENOATES; UMPOLUNG ADDITION-REACTION; CROSS-COUPLING REACTION; MORITA-BAYLIS-HILLMAN; DIASTEREOSELECTIVE SYNTHESIS; SEQUENTIAL ANNULATION; BOND FORMATION; 3+2 CYCLOADDITION; MICHAEL ADDITION; DOMINO REACTION in [Feng, Jiaxu; Huang, You] Nankai Univ, Coll Chem, State Key Lab, Tianjin 300071, Peoples R China; [Feng, Jiaxu; Huang, You] Nankai Univ, Coll Chem, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China in 2020.0, Cited 105.0. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3. Product Details of 59-48-3

A phosphine-catalyzed remote 1,7-addition of vinyl allenoates has been developed, providing a series of 1,3-dienes derivatives in high yields (up to 99%) and with good chemo-, regio-, and stereoselectivity. This reaction demonstrated that the introduction of vinyl in allenoates effectively extended reaction types of phosphine-catalyzed nucleophilic addition of allenoates, leading to concise synthesis of diene carboxylates. Notably, the enantioselective variant of this 1,7-addition can also be performed by chiral phosphine catalyst.

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Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

An article Phosphine-Catalyzed Remote 1,7-Addition for Synthesis of Diene Carboxylates WOS:000526394500004 published article about GAMMA-SUBSTITUTED ALLENOATES; UMPOLUNG ADDITION-REACTION; CROSS-COUPLING REACTION; MORITA-BAYLIS-HILLMAN; DIASTEREOSELECTIVE SYNTHESIS; SEQUENTIAL ANNULATION; BOND FORMATION; 3+2 CYCLOADDITION; MICHAEL ADDITION; DOMINO REACTION in [Feng, Jiaxu; Huang, You] Nankai Univ, Coll Chem, State Key Lab, Tianjin 300071, Peoples R China; [Feng, Jiaxu; Huang, You] Nankai Univ, Coll Chem, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China in 2020.0, Cited 105.0. Recommanded Product: 59-48-3. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3

A phosphine-catalyzed remote 1,7-addition of vinyl allenoates has been developed, providing a series of 1,3-dienes derivatives in high yields (up to 99%) and with good chemo-, regio-, and stereoselectivity. This reaction demonstrated that the introduction of vinyl in allenoates effectively extended reaction types of phosphine-catalyzed nucleophilic addition of allenoates, leading to concise synthesis of diene carboxylates. Notably, the enantioselective variant of this 1,7-addition can also be performed by chiral phosphine catalyst.

Recommanded Product: 59-48-3. Welcome to talk about 59-48-3, If you have any questions, you can contact Feng, JX; Huang, Y or send Email.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Quality Control of Indolin-2-one. In 2019 J MED CHEM published article about PLASMODIUM-FALCIPARUM M1; ACUTE NONLYMPHOCYTIC LEUKEMIA; MOLECULAR-DYNAMICS; CLINICAL-SIGNIFICANCE; EFFICIENT GENERATION; STRUCTURAL BASIS; AM1-BCC MODEL; CD13; BESTATIN; CANCER in [Lee, Jisook; Vinh, Natalie B.; Schembri, Luke S.; Gazdik, Michelle; Scammells, Peter J.] Monash Univ, Monash Inst Pharmaceut Sci, Med Chem, Parkville Campus, Parkville, Vic 3052, Australia; [Charman, Susan A.] Monash Univ, Monash Inst Pharmaceut Sci, Ctr Drug Candidate Optimisat, Parkville Campus, Parkville, Vic 3052, Australia; [Drinkwater, Nyssa; Yang, Wei; Sivaraman, Komagal Kannan; McGowan, Sheena] Monash Univ, Infect & Immun Program, Biomed Discovery Inst, Clayton Campus, Clayton, Vic 3800, Australia; [Drinkwater, Nyssa; Yang, Wei; Sivaraman, Komagal Kannan; McGowan, Sheena] Monash Univ, Dept Microbiol, Clayton Campus, Clayton, Vic 3800, Australia; [Grin, Peter M.; Butler, Georgina S.; Overall, Christopher M.] Univ British Columbia, Life Sci Inst, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z3, Canada; [Butler, Georgina S.; Overall, Christopher M.] Univ British Columbia, Life Sci Inst, Dept Oral Biol & Med Sci, Vancouver, BC V6T 1Z3, Canada; [Grin, Peter M.; Butler, Georgina S.; Overall, Christopher M.] Univ British Columbia, Life Sci Inst, Ctr Blood Res, Vancouver, BC V6T 1Z3, Canada in 2019, Cited 80. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3.

Aminopeptidase N (APN/CD13) is a zinc-dependent M1 aminopeptidase that contributes to cancer progression by promoting angiogenesis, metastasis, and tumor invasion. We have previously identified hydroxamic acid-containing analogues that are potent inhibitors of the APN homologue from the malarial parasite Plasmodium falciparum M1 aminopeptidase (PfA-M1). Herein, we describe the rationale that underpins the repurposing of PfA-MI inhibitors as novel APN inhibitors. A series of novel hydroxamic acid analogues were developed using a structure-based design approach and evaluated their inhibition activities against APN. N-(2-(Hydroxyamino)-2-oxo-1-(3′,4′,5′-trifluoro-[1,1′-biphenyl]-4-yOethyl)-4(methylsulfonamido)benzamide (6ad) proved to be an extremely potent inhibitor of APN activity in vitro, selective against other zinc-dependent enzymes such as matrix metalloproteases, and possessed limited cytotoxicity against Ad293 cells and favorable physicochemical and metabolic stability properties. The combined results indicate that compound 6ad may be a useful lead for the development of anticancer agents.

Quality Control of Indolin-2-one. Welcome to talk about 59-48-3, If you have any questions, you can contact Lee, J; Vinh, NB; Drinkwater, N; Yang, W; Sivaraman, KK; Schembri, LS; Gazdik, M; Grin, PM; Butler, GS; Overall, CM; Charman, SA; McGowan, S; Scammells, PJ or send Email.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Quality Control of Indolin-2-one. I found the field of Chemistry very interesting. Saw the article Models for Understanding Divergent Reactivity in Lewis Acid-Catalyzed Transformations of Carbonyls and Olefins published in 2020.0, Reprint Addresses Reid, JP (corresponding author), Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA.; Schindler, CS (corresponding author), Univ Michigan, Willard Henry Dow Lab, Dept Chem, Ann Arbor, MI 48109 USA.. The CAS is 59-48-3. Through research, I have a further understanding and discovery of Indolin-2-one.

Carbonyl-ene, Prins, and carbonyl-olefin metathesis reactions represent powerful strategies for carbon-carbon bond formation relying on Lewis acid catalysts. Although common Lewis acids are able to provide efficient activation, the reactions often proceed with low regio- or chemoselectivity, while high selectivity frequently requires the use of well-designed metal-ligand complexes. Here we demonstrate that simple Lewis acids including Me2AlCl, FeCl3, and SnCl4 can show remarkable selectivity in differentiating between distinct transformations of carbonyl and olefin functional groups, resulting in either carbonyl-ene or carbonyl-olefin metathesis products. Specifically, we report the development of predictive multivariate linear regression models that rely on kinetic and thermodynamic information obtained in DFT calculations to gain important insights into the complex potential energy surfaces (PES) of these competing reaction paths. The presented results further our understanding of Lewis acid reactivity and suggest that even simple Lewis acids have the potential to function as highly selective catalysts.

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Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

In 2019 ADV SYNTH CATAL published article about SECONDARY AMIDES; N-ALKYLATION; CHEMOSELECTIVE REDUCTION; TERTIARY AMIDES; ACID; DERIVATIVES; CHEMISTRY; NITRILES; ESTERS; CARBON in [Pan, Yixiao; Luo, Zhenli; Xu, Xin; Zhao, Haoqiang; Han, Jiahong; Xu, Lijin] Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China; [Fan, Qinghua] Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China; [Xiao, Jianliang] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England in 2019, Cited 59. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3. Formula: C8H7NO

A ruthenium(II)-catalyzed deoxygenative transfer hydrogenation of amides to amines using HCO2H/NEt3 as the reducing agent is reported for the first time. The catalyst system consisting of [Ru(2-methylallyl)(2)(COD)], 1,1,1-tris(diphenylphosphinomethyl) ethane (triphos) and Bis(trifluoromethane sulfonimide) (HNTf2) performed well for deoxygenative reduction of various secondary and tertiary amides into the corresponding amines in high yields with excellent selectivities, and exhibits high tolerance toward functional groups including those that are reduction-sensitive. The choice of hydrogen source and acid co-catalyst is critical for catalysis. Mechanistic studies suggest that the reductive amination of the in situ generated alcohol and amine via borrowing hydrogen is the dominant pathway.

Formula: C8H7NO. Welcome to talk about 59-48-3, If you have any questions, you can contact Pan, YX; Luo, ZL; Xu, X; Zhao, HQ; Han, JH; Xu, LJ; Fan, QH; Xiao, JL or send Email.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Quality Control of Indolin-2-one. In 2020.0 ANGEW CHEM INT EDIT published article about CROSS-COUPLING REACTIONS; FUNCTIONALIZATION; DERIVATIVES; OXINDOLES; ETHERS; BONDS; PHOTOSENSITIZERS; HYDROCARBONS; ACTIVATION; ANNULATION in [Hu, Ren-Ming; Han, Dong-Yang; Li, Ning; Huang, Jie; Feng, Yu; Xu, Da-Zhen] Nankai Univ, State Key Lab, Coll Chem, Natl Engn Res Ctr Pesticide Tianjin, Tianjin 300071, Peoples R China; [Hu, Ren-Ming; Han, Dong-Yang; Li, Ning; Huang, Jie; Feng, Yu; Xu, Da-Zhen] Nankai Univ, Inst Elementoorgan Chem, Coll Chem, Tianjin 300071, Peoples R China in 2020.0, Cited 61.0. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3.

Presented herein is the first direct alkylation and hydroxylation reaction between two different C(sp(3))-H bonds, indolin-2-ones and alkyl-substituted N-heteroarenes, through an oxidative cross-coupling reaction. The reaction is catalyzed by a simple iron salt under mild ligand-free and base-free conditions. The reaction is environmentally benign, employs air (molecular oxygen) as the terminal oxidant and oxygen source for the synthesis of O-containing compounds, and produces only water as the byproduct.

Quality Control of Indolin-2-one. Welcome to talk about 59-48-3, If you have any questions, you can contact Hu, RM; Han, DY; Li, N; Huang, J; Feng, Y; Xu, DZ or send Email.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

An article Selective C3-alkenylation of oxindole with aldehydes using heterogeneous CeO2 catalyst WOS:000531430200008 published article about ENANTIOSELECTIVE CONSTRUCTION; AMIDES; NITRILES; ALCOHOLS; ESTERS; ACTIVATION; HYDRATION; VERSATILE; ISATIN in [Rashed, Md Nurnobi; Touchy, Abeda Sultana; Jeon, Jaewan; Siddiki, S. M. A. Hakim; Toyao, Takashi; Shimizu, Ken-ichi] Hokkaido Univ, Inst Catalysis, N-21,W-10, Sapporo, Hokkaido 0010021, Japan; [Chaudhari, Chandan] Nagoya Univ, Grad Sch Engn, Dept Chem Syst Engn, Nagoya, Aichi 4648603, Japan; [Toyao, Takashi; Shimizu, Ken-ichi] Kyoto Univ, Elements Strategy Initiat Catalysts & Batteries, Kyoto 6158520, Japan in 2020.0, Cited 39.0. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3. Recommanded Product: 59-48-3

We report herein that a commercially available CeO2 is an active and reusable catalyst for the C3-selective alkenylation of oxindole with aldehydes under solvent-free conditions. This. catalytic method is generally applicable to different aromatic and aliphatic aldehydes, giving 3-alkyledene-oxindoles in high yields (87%-99%) and high stereoselectivities (79%-93% to E-isomers). This is the first example of the catalytic synthesis of 3-alkenyl-oxindoles from oxindole and various aliphatic aldehydes. The Lewis acid-base interaction between Lewis acid sites on CeO2 and benzaldehyde was studied by in situ IR. The structure-activity relationship study using CeO2 catalysts with different sizes suggests that defect-free CeO2 surface is the active site for this reaction. (C) 2020, Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.

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Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem