Category: 954255-04-0

We’ll be discussing some of the latest developments in chemical about CAS: 954255-04-0. Application of 954255-04-0

Example 39 Adamantan-1-yl-(5,6-difluoro-2,3-dihydro-indol-1-yl)-methanone In analogy to the procedure described for the synthesis of adamantan-1-yl-(3,4-dihydro-1H-isoquinolin-2-yl)-methanone (example 1) the title compound was prepared from 5,6-difluoroindoline and adamatanecarbonyl chloride as light brown solid. MS(m/e): 318.3 (MH+).

Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.Read on for other articles about 954255-04-0.

Reference:
Patent; Hoffmann-La Roche Inc.; Kimbara, Atsushi; Grether, Uwe; Nettekoven, Matthias; Puellmann, Bernd; Rogers-Evans, Mark; Schulz-Gasch, Tanja; US2015/111886; (2015); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 954255-04-0, name is 5,6-Difluoroindoline, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C8H7F2N

Example 46 5-(6-(5,6-difluoroindoline-1-carbonyl)pyrimidin-4-ylamino)-1,3-dihydrospiro[indene-2,3′-pyrrolo[2,3-b]pyridin]-2′(1’H)-one 0.10 g (0.24 mmol) 6-(2′-oxo-1,1′,2′,3-tetrahydrospiro[indene-2,3′-pyrrolo[2,3-b]pyridin]-5-ylamino)pyrimidine-4-carboxylic acid hydrochloride, 50 mg (0.26 mmol) 5,6-difluoro-2,3-di-hydro-1H-indole, 0.10 mL (0.72 mmol) TEA and 80 mg (0.25 mmol) TBTU in 1.8 mL DMF were stirred overnight at RT. The purification was carried out by preparative HPLC-MS. The product-containing fractions were combined and lyophilised. Yield: 45 mg (36% of theory) ESI-MS: m/z=511 (M+H)+ Rt (HPLC-MS): 1.61 min (method C)

According to the analysis of related databases, 954255-04-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2011/21500; (2011); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Application of 954255-04-0,Some common heterocyclic compound, 954255-04-0, name is 5,6-Difluoroindoline, molecular formula is C8H7F2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5,6-difluoro-indoline 0.40g (2.58mmol),3,5-dimethoxybromobenzene 0.58 g (2.71 mmol),3% molar amount of Pd(OAc) 2 (17 mg),6% molar amount of P(t-Bu)3.HBF4 (45 mg),Sodium tert-butoxide (0.50 g, 5.16 mmol) was added to 40 mL of toluene.Heating at 110 C for 12 h,filter,The filtrate is depressurized to remove the solvent.Column chromatography (PE: CH2Cl2 = 5:1) gave 0.45 g of white crystals.The yield was 60%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5,6-Difluoroindoline, its application will become more common.

Electric Literature of 954255-04-0,Some common heterocyclic compound, 954255-04-0, name is 5,6-Difluoroindoline, molecular formula is C8H7F2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 39 Adamantan-1-yl-(5,6-difluoro-2,3-dihydro-indol-1-yl)-methanone In analogy to the procedure described for the synthesis of adamantan-1-yl-(3,4-dihydro-1H-isoquinolin-2-yl)-methanone (example 1) the title compound was prepared from 5,6-difluoroindoline and adamatanecarbonyl chloride as light brown solid. MS(m/e): 318.3 (MH+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5,6-Difluoroindoline, its application will become more common.