Some common heterocyclic compound, 940054-45-5, name is 4-Chloro-6-fluoroindoline-2,3-dione, molecular formula is C8H3ClFNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 4-Chloro-6-fluoroindoline-2,3-dione
Stage 5: 2-amino-6-chloro-4-fluoro-benzoic acid (main isomer) and 2-amino-4-chloro-6-fluoro-benzoic acid (lesser isomer) First sodium hydroxide (10.7 g, 267 mmol) and then 30% hydrogen peroxide (10.7 ml) in water (96 ml) were added to a suspension of the product mixture from stage 4 (8.00 g, 40 mmol) in water (200 ml) at 0 C. The mixture was stirred at room temperature overnight and then brought to pH 3.3 with formic acid (approx. 20 ml, severe foaming). The title compound which had precipitated out was filtered off and dried over phosphorus pentoxide in vacuo. The aqueous solution was extracted with ethyl acetate (2*150 ml). The pH of the aqueous phase was corrected to 3.3 and extraction was carried out again with ethyl acetate (150 ml). The combined organic phases were dried with sodium sulfate and concentrated and the residue was dried in vacuo. Yield: 7.30 g (95%) of the mixture of the regioisomers in the ratio of 9:1, brown solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 940054-45-5, its application will become more common.
Reference:
Patent; Gruenenthal GmbH; US2008/293749; (2008); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem