Never Underestimate The Influence Of 5-Bromoindoline-2,3-dione

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In an article, author is Lv, Xialei, once mentioned the application of 87-48-9, SDS of cas: 87-48-9, Name is 5-Bromoindoline-2,3-dione, molecular formula is C8H4BrNO2, molecular weight is 226.03, MDL number is MFCD00149345, category is indolines-derivatives. Now introduce a scientific discovery about this category.

Regulating the photophysical properties of highly twisted TADF emitters by concurrent through-space/-bond charge transfer

A series of thermally activated delayed fluorescence (TADF) emitters with folded-layout, namely SF12oTz, SF23oTz and SF34oTz are strategically designed and synthesized by substituting 4,6-diphenyl-1,3,5-triazine (Tz) with indoline-fused spirobifluorene donors at the ortho position. The substitution position of the spirobifluorene-based donors changes the steric hindrance and conjugation degree of molecules, which dominate the excited state levels (singlet and triplet) and intramolecular charge transfer (ICT) state properties, resulting in simultaneous through bond charge transfer (TBCT) and through space charge transfer (TSCT) transitions in one single molecule. Among them, SF23oTz and SF12oTz both show dual emissions with LE (local excited) and CT (charge transfer) features in different solvents, whereas SF34oTz possesses single emission from TSCT (96.8%) contributed Si . Furthermore, SF12oTz exhibits more TBCT (32.0%) contributed emission compared with SF23oTz (20.6%), which results in much higher ratio of delayed fluorescence (79.1% vs. 39.2%) because of the more effective channel of TBCT over TSCT to realize charge transfer from donors to acceptor. In devices, SF12oTz and SF23oTz with more contribution of TBCT achieve high EQE(max) of 22.4% and 19.6% with reduced efficiency roll-off. The mechanism studies reveal that the control of TBCT and TSCT in these molecules play a significant role in regulating photophysical properties and improving the device performance of TADF-OLEDs.

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Let¡¯s face it, organic chemistry can seem difficult to learn, Product Details of 87-48-9, Especially from a beginner¡¯s point of view. Like 87-48-9, Name is 5-Bromoindoline-2,3-dione, molecular formula is indolines-derivatives, belongs to indolines-derivatives compound. In a document, author is Wu, Wen-Tao, introducing its new discovery.

Diastereoselective Synthesis of Spiro[indoline-3,7 ‘-pyrrolo[1,2-a]azepines] via Sequential [3+2] Cycloaddition and Ring Expansion Reaction

Spiro[indoline-3,7 ‘-pyrrolo[1,2-a]azepines] were conveniently synthesized in satisfactory yields and with high diastereoselectivity from three-component reaction of L-proline, isatins and chalcones and sequential reaction with dimethyl but-2-ynedioate or methyl propiolate in refluxing methanol. The ferrocenyl-chalcones and dibenzylideneacetones were also successfully used in this one-pot two-step reaction to give novel ferrocenyl and styryl-substituted spiro compounds. The reaction mechanism included domino [3+2] cycloadddtition reaction of azomethine ylide with chalcone and ring-expansion reaction ofin situgenerated spiro[indoline-3,3 ‘-pyrrolizine] with electron-deficient alkynes.

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Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 87-48-9, Name is 5-Bromoindoline-2,3-dione. In a document, author is Meng, Tingting, introducing its new discovery. Category: indolines-derivatives.

Recent advances in indole dimers and hybrids with antibacterial activity against methicillin-resistantStaphylococcus aureus

Methicillin-resistantStaphylococcus aureus(MRSA), one of the major and most dangerous pathogens in humans, is a causative agent of severe pandemic of mainly skin and soft tissue and occasionally fatal infections. Therefore, it is imperative to develop potent and novel anti-MRSA agents. Indole derivatives could act against diverse enzymes and receptors in bacteria, occupying a salient place in the development of novel antibacterial agents. Dimerization and hybridization are common strategies to discover new drugs, and a number of indole dimers and hybrids possess potential antibacterial activity against a panel of clinically important pathogens including MRSA. Accordingly, indole dimers and hybrids are privileged scaffolds for the discovery of novel anti-MRSA agents. This review outlines the recent development of indole dimers and hybrids with a potential activity against MRSA, covering articles published between 2010 and 2020. The structure-activity relationship and the mechanism of action are also discussed to facilitate further rational design of more effective candidates.

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 87-48-9, Name is 5-Bromoindoline-2,3-dione, molecular formula is C8H4BrNO2. In an article, author is Kiamehr, Mostafa,once mentioned of 87-48-9, Product Details of 87-48-9.

Efficient synthesis of pentacyclic benzosultam-annulated thiopyranoindoles via domino Knoevenagel / intramolecular hetero-Diels-Alder reactions in water

A convenient catalyst-free synthesis of hitherto unknown pentacyclic benzosultam-annulated thiopyranoindole derivatives is reported which proceeds via domino Knoevenagel / intramolecular hetero-Diels-Alder reactions of (E)-N-alkyl-2-aryl-N-(2-formylphenyl)ethene-1-sulfonamides with indoline-2-thiones in water. The products were obtained regioselectively in high yields.

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In an article, author is Steinhauer, J., once mentioned the application of 87-48-9, Recommanded Product: 5-Bromoindoline-2,3-dione, Name is 5-Bromoindoline-2,3-dione, molecular formula is C8H4BrNO2, molecular weight is 226.03, MDL number is MFCD00149345, category is indolines-derivatives. Now introduce a scientific discovery about this category.

Model Catalytic Studies of Liquid Organic Hydrogen Carriers: Indole/Indoline/Octahydroindole on Ni(111)

N-heterocycles belong to the class of so-called liquid organic hydrogen carriers (LOHCs), which have been identified as suitable materials for chemical hydrogen storage due to favorable hydrogen storage capacity and reaction kinetics. In this contribution, we focus on the dehydrogenation reaction of hydrogen-rich octahydroindole, its dehydrogenation intermediate indoline, and hydrogen-lean indole. Octahydroindole has a hydrogen storage capacity of 6.4 wt %, and indoline has 1.7 wt %. We investigated the mechanism of the temperature-induced dehydrogenation of the three compounds after adsorption on Ni(111) at low temperatures. Nickel is attractive as an effective and low-priced dehydrogenation catalyst, which potentially could replace more expensive Pt and Pd in industrial applications. We compare the obtained results with our previous work on Pt(111) for the same LOHC system and for N-ethylcarbazole/H-12-N-ethylcarbazole. A comprehensive understanding of the reaction mechanism was obtained by combining high-resolution X-ray photoelectron spectroscopy with temperature-programmed desorption lab experiments. For all three compounds, we find dehydrogenation at the nitrogen atom above 270 K (indole, >= 130 K; indoline, >240 K; octahydroindole, >270 K). For indoline and octahydroindole, we observe simultaneous dehydrogenation at the carbon atoms, resulting in an indolide surface species. For octahydroindole, small amounts of side products and decomposition products are observed throughout the reaction pathway. Above 380 K, the indolide species decomposes into fragments for all three compounds.

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Now Is The Time For You To Know The Truth About 5-Bromoindoline-2,3-dione

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Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 87-48-9, Name is 5-Bromoindoline-2,3-dione, molecular formula is , belongs to indolines-derivatives compound. In a document, author is Vinoth, Nangagoundan, Recommanded Product: 87-48-9.

Catalyst-Free Three-Component Synthesis, Antibacterial, Antifungal, and Docking Studies of Spiroindoline Derivatives

A sequence of functionalized 1 ‘ H-spiro-[indoline-3,5 ‘-pyrimido[4,5-b]quinoline] – 2,2 ‘,4 ‘ (3 ‘ H,10 ‘ H)-trione derivatives have been synthesized by a catalyst-free three-component reaction of barbituric acid with arylamines and isatin under aqueous conditions. Neutral reaction conditions, high yields, and operational simplicity are the important features of the present protocol. The molecular docking studies of all the synthesized compounds were performed with jackbean urease (PDB ID: 3LA4). The results suggest that the compounds 4a-4j showed good binding affinities with the active site of jackbean urease having an inhibition constant Ki = 76.26 nm. This study offers the first example of the exhibition of urease inhibitory potential by spiro indoline derivatives paying route to develop more potent anti-urease compounds of medicinal and agricultural interest. The selected compounds 4a and 4j were evaluated for antimicrobial studies.

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Discovery of 5-Bromoindoline-2,3-dione

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 87-48-9 is helpful to your research. COA of Formula: C8H4BrNO2.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 87-48-9, Name is 5-Bromoindoline-2,3-dione, SMILES is O=C1NC2=C(C=C(Br)C=C2)C1=O, belongs to indolines-derivatives compound. In a document, author is Pal, Kaushik, introduce the new discover, COA of Formula: C8H4BrNO2.

Deciphering interior polarity of lysosome in live cancer and normal cells using spectral scanning microscopy

A lysosome specific, pH tolerant, and polarity-sensitive fluorescent probe (LyPol) is designed and synthesized for the determination of lysosomal polarity in live cells. LyPol possesses an intramolecular charge transfer (ICT) properties with high quantum yield in water and in other polar solvents such as methanol, ethanol, dimethyl sulfoxide, acetonitrile, etc. The fluorescence maxima and lifetime increase linearly with a non-specific manner with an increase in the polarity of its surrounding environment. A morpholine group connected with an alkyl linker acts as a lysosome directing moiety, which is attached to the fluorescent core of LyPol. The selective localization of LyPol inside the lysosome was confirmed with live-cell confocal imaging. Further, the spectral scanning confocal technique was utilized to determine the emission spectrum of LyPol inside lysosome, and the polarity turns out to be quite lower as compared to water. Moreover, the combined spectroscopic and live-cell microscopy confirms that the interior of the lysosome is significantly non-polar in cancer cells compared to normal cells. We believe that this report on the measuring polarity inside the biological system with a solvatofluorochromic probe will be of immense interest to researchers working in the multidisciplinary area of biophysics, microscopy, chemical biology, and organelle biology.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 87-48-9 is helpful to your research. COA of Formula: C8H4BrNO2.

The important role of 87-48-9

The synthetic route of 87-48-9 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 87-48-9, These common heterocyclic compound, 87-48-9, name is 5-Bromoindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of 2-bromoaniline or 3-bromoaniline (110 mmol, 18.9 g), chloral hydrate (118.8 mmol,19.6 g), anhydrous sodium sulfate (880 mmol, 125 g), and hydroxylamine hydrochloride (347.6mmol, 24.2 g) in water (700 mL) was heated under reflux for 25 min to form a yellow precipitate. 50mL of ethanol was added after that and left to boil for another 4 min before filtration. The resultedisonitrosoacetanilide was then heated with sulfuric acid (150 mL) at 70 C for about 10 min thenpoured into ice water to form an orange precipitate. When using 3-bromoaniline, an extra step ofseparation is required by solving the resulted mixture in 0.25 M NaOH (1 L), filtering it, then addingacetic acid (100 mL) to afford 4-bromoistain as a precipitate. 6-Bromoistin can be then obtained whenlowering the pH of the solution to 1 by hydrochloric acid 37%.All substituted bromo-isatins were methylated by stirring (22 mmol, 4.97 g) with sodiumhydride (2 mmol, 0.968 g) and dimethylsulfate (23.1 mmol, 2.19 mL) in dried DMF (50 mL) undernitrogen atmosphere. The resulting mixture was poured after 2 h in ice water (100 mL) to form anorange precipitate.The methylated bromo-isatins (2 mmol, 0.480 g) were treated after that with oxindole (2 mmol,0.226 g) in a 100:1 mixture of glacial acetic acid and hydrochloric acid 37% (12 mL) in reflux for about 3 h. Then, they were poured in ice water (50 mL) to afford 5-, 6- and 7-bromomeisoindigo. While 4′-, 5′-, 6′- and 7′-bromomeisoindigo were obtained by reacting unmethylated bromo-isatins(2 mmol, 0.452 g) with 1-methyloxindole (2 mmol, 0.294 g) in the same conditions. The resultedprecipitates were washed with water, ethanol (2 x 10 mL), and diethylether (2 10 mL) then dried. 3.2.1. 5-Bromo-1-MeisoindigoYield: 70%. 1H-NMR (400 MHz, DMSO, d6) delta ppm 3.19 (s, 3H), 6.83 (dd, 3J = 7.8 Hz, 4J = 0.5 Hz, 1H)6.96 (m, 1H), 6.97 (d, 3J = 8.4 Hz, 1H), 7.35 (td, 3J = 7.6 Hz, 4J = 1.1 Hz), 7.58 (dd, 3J = 8.4 Hz, 4J = 2.1 Hz),9.06 (dd, 3J = 8.1 Hz, 4J = 0.5 Hz), 9.31 (d, 4J = 2.0 Hz, 1H), 10.94 (s, 1H). 13C-NMR (100 MHz, DMSO,d6) delta ppm 26.6, 110.2, 110.7, 114.0, 121.8, 121.9, 123.0, 130.2, 131.1, 131.5, 133.8, 134.8, 135.6, 144.4, 145.0,167.2, 169.3. Anal. calcd. for C17H11BrN2O2: C 57.49, H 3.12, N 7.89; found: C 57.44, H 3.18, N 793.HRMS (ESI) calculated m/z: 376.9896; found C17H11BrN2O2; m/z: 376.9896 [M + H]+.

The synthetic route of 87-48-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Tegethoff, Jana; Bischoff, Roland; Saleh, Sawsan; Blagojevic, Biljana; Merz, Karl-Heinz; Cheng, Xinlai; Molecules; vol. 22; 9; (2017);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Share a compound : 87-48-9

The synthetic route of 87-48-9 has been constantly updated, and we look forward to future research findings.

Reference of 87-48-9,Some common heterocyclic compound, 87-48-9, name is 5-Bromoindoline-2,3-dione, molecular formula is C8H4BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The preparation was divided into two steps. Firstly, substituent indoline-2,3-dione (1 equiv) was dissolved in ethanol (10 mL), hydrazine hydrate (2 mL) was added. The reaction mixture was refluxed with magnetic stirring for 3 h and cooled to 0 C, then sodium hydroxide (3 equiv) was added, refluxed for 0.5 h and cooled to room temperature, then 150 mL water was added. The mixture was acidified by adding 2 N hydrochloric acid to pH 2, and extracted twice with dichloromethane. The organic filtrate was washed twice with brine, dried (Na2SO4), and then concentrated to give corresponding indolin-2-one by high-vacuum drying. Secondly, a mixture of the corresponding indolin-2-one (1 equiv) and furan-2-carbaldehyde (1 equiv) in ethanol was added two drops of piperidine and refluxed with magnetic stirring for 5 h. After the mixture cooled, the precipitate was filtered, washed with cold ethanol, dried, and recrystallized from methanol to afford the terminal product.

The synthetic route of 87-48-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhong, Ye; Xue, Mengzhu; Zhao, Xue; Yuan, Jun; Liu, Xiaofeng; Huang, Jin; Zhao, Zhenjiang; Li, Honglin; Xu, Yufang; Bioorganic and Medicinal Chemistry; vol. 21; 7; (2013); p. 1724 – 1734;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Extended knowledge of 87-48-9

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromoindoline-2,3-dione, its application will become more common.

Related Products of 87-48-9,Some common heterocyclic compound, 87-48-9, name is 5-Bromoindoline-2,3-dione, molecular formula is C8H4BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: TiCl4 (0.7 mL, 6 mmol)was added to a stirred suspension of Zn powder (0.78 g, 12 mmol) in freshlydistilled anhydrous THF (15 mL) at room temperature (rt) under a dry N2atmosphere. After completion of the addition, the mixture was refluxed for 2 h.The suspension of the low-valent titanium reagent thus-formed was cooled tort. A solution of isatin or its derivatives 1 or 3 (2 mmol) in THF (10 mL) wasadded dropwise. The mixture was stirred at room temperature for about 5 minunder N2. After this period, the thin layer chromatography (TLC) analysis of themixture showed the reaction completed. The reaction mixture was quenchedwith 3% HCl (15 mL) and extracted with CHCl3 (3 50 mL). The combinedextracts were washed with water (3 50 mL) and dried over anhydrousNa2SO4. After evaporation of the solvent under reduced pressure, the crudeproduct was purified by column chromatography (petroleum ether/ethylacetate = 5:1) to give the pure products 2 or 4.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromoindoline-2,3-dione, its application will become more common.

Reference:
Article; Lin, Wei; Hu, Ming-Hua; Feng, Xian; Fu, Lei; Cao, Cheng-Pao; Huang, Zhi-Bin; Shi, Da-Qing; Tetrahedron Letters; vol. 55; 14; (2014); p. 2238 – 2242;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem