Reference of 87-48-9, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 87-48-9, Name is 5-Bromoindoline-2,3-dione, SMILES is O=C1NC2=C(C=C(Br)C=C2)C1=O, belongs to indolines-derivatives compound. In a article, author is Yuan Rui, introduce new discover of the category.
Synthesis of 1,7-Bis(N-substituted-aminomethyl)-2,8-dihydroxy-Troger’s Bases and Their Application in Aldol-Ullmann Reaction
1,7-Bis(N-substituted-aminomethyl)-2,8-dihydroxy-Troger’s bases (4) were synthesized and used as efficient organocatalyst for the Aldol reaction of 4-hydroxylcoumarin and 2-benzylidenemalononitrile (or methyl(ethyl)-2-cyano-3-phenylacrylate) to afford 2-amino-4-aryl-5oxo-4H,5H-pyrano[3,2-c]chromene-3-carbonitriles (carboxylates) (8). Subsequently, they were used as the efficient ligand to promote the Pd-catalyzed reaction to give 7-aryl-7,12-dihydro-6H-chromeno[3′,4′:5,6]pyrano[23-b]indol-6-one (10) and 5′ (or 5′,7)-substituted-6H,12H-spiro[chromeno[3′,4′.5,6]-pyrano[2,3-b]indole-7,3′-indoline]-2′,6-dione (12), respectively. The anti-cancer activity on human three positive breast cancer cells (MCF-7), human three negative breast cancer cells (MDA-MB-231), human hepatoma cells (HepG2), human hepatoma cells (MHCC-97H) and cytotoxicity on human hepatocyte cells (LO2) of catalyst 4 and all products in vitro were evaluated. 1,7-Bis((methylamino)methyl)-6H,12H-5,11-methanodibenzo[bf][1,5]diazocine-2,8-diol (4b) had selective inhibition (inhibition rate >30%) on MCF-7 cells while 1,7-bis(((1-phenylethyl)amino)methyl)-6H,12H-5,11-methanodibenzo[bf][1,5]diazocine-2,8-diol (4d) and 1,7-bis(((pyridin-2-ylmethyl)amino)methyl)-6H,12H-5,11-methanodibenzo[bf][1,5]diazocine-2,8-diol (4e) had selective inhibition on MDA-MB-231 cells. 2-Amino-5-oxo-4-(3,4,5-trimethoxyphenyl)-4H,5H-dihydropyrano[3,2-c]chromene-3-carbonitrile (8q) had strong inhibitory effects on three kinds of cancer cells except MDA-MB-231 while 2-amino-4-(4-bromophenyl)-5-oxo-4H,5H-pyrano[3,2-elchromene-3-carbonitrile (8a), 2-amino-4-(2,4-dichlorophenyl)-5-oxo-4H,5H-dihydropyrano[3,2-elchromene-3-carbonitrile (8e), 2-amino-4-(3-fluorophenyl)-5-oxo-4H,5H-pyrano[3,2-eichromene-3-carbonitrile (8m) and 2-amino-4-(3-bromophenyl)-5-oxo-4H,5H-dihydropyrano[3,2-c]chromene-3-carbonitrile (8n) had strong inhibitory effects on four kinds of cancer cells. However, all the compounds showed cytotoxicity to normal LO2 cells which prompts, the necessary of structure modification to reduce the toxicity.
Reference of 87-48-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 87-48-9.