Category: 84378-94-9

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 84378-94-9, name is 4-Chloro-5-fluoroindoline-2,3-dione, A new synthetic method of this compound is introduced below., Application In Synthesis of 4-Chloro-5-fluoroindoline-2,3-dione

General procedure: To an ethanolic solution of triazole-hydrazide 5 (1.0mmol) was added equimolar amount of substituted Isatin (8a-i) and refluxed overnight at 80C. After completion of the reaction, crude obtained was filtered, washed with water to get Isatin-triazole hydrazones (9a-i) which was purified by column chromatography eluted with acetone: DCM (1:9) to afford the title compounds in moderate to good yield [53].

The synthetic route of 84378-94-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Aneja, Babita; Khan, Nashrah Sharif; Khan, Parvez; Queen, Aarfa; Hussain, Afzal; Rehman, Md. Tabish; Alajmi, Mohamed F.; El-Seedi, Hesham R.; Ali, Sher; Hassan, Md. Imtaiyaz; Abid, Mohammad; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 840 – 852;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 84378-94-9, name is 4-Chloro-5-fluoroindoline-2,3-dione, A new synthetic method of this compound is introduced below., Computed Properties of C8H3ClFNO2

2-amino-5-fluoro-6-chlorobenzoic acid 0.01mol joined is provided with a reflux condenser, magneton, thermometer in three-necked bottle, adding toluene 15 ml, dry SOCl 2 3 ml, reflux 1h, stopping reaction, rotary evaporation under reduced pressure to remove the solvent and redundant SOCl 2. Then added to the flask 0.01moL of 5-fluoro-4-chloro Indoloquinone (5-fluoro-6-chloro Indoloquinone) and 15 ml of dichloromethane, to continue to reflux reaction 1h, cooling to room temperature, filtered, to obtain the yellow solid, washing with methanol, dichloromethane or toluene recrystallization

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Northwest University; Huo, Baolong; Wang, Cuiling; (52 pag.)CN105330666; (2016); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Adding a certain compound to certain chemical reactions, such as: 84378-94-9, name is 4-Chloro-5-fluoroindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 84378-94-9, HPLC of Formula: C8H3ClFNO2

(b) 7.8 g (0.039 mol) of 4-chloro-5-fluoro-isatin are suspended in 50 ml of 100 percent acetic acid, treated with 0.25 ml of concentrated sulphuric acid and then 4.4 ml (0.043 mol) of 30 percent hydrogen peroxide are added dropwise thereto. The mixture is subsequently heated to 70 for 2.5 hours, then cooled to 10 and filtered. The crude product is recrystallized from acetone/hexane, there being obtained 6-chloro-5-fluoro-isatoic acid anhydride of melting point 275-278 (decomposition).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Some common heterocyclic compound, 84378-94-9, name is 4-Chloro-5-fluoroindoline-2,3-dione, molecular formula is C8H3ClFNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 4-Chloro-5-fluoroindoline-2,3-dione

2.00 g of 4-chloro-5-fluoroindole quinone was placed in 100 ml three-necked flask, 40 ml of toluene and 1.08 g of potassium borohydride were added in portions. The reaction was as follows: stirring and refluxing, reaction time: 5. Oh , The reaction temperature: 40 C, after the completion of the reaction, the solvent was removed by rotary evaporation to give 0.93 g of crude product of purple solid 4-C1-5-F-4 ‘-Cl-5’ -F-indirubin, The Ethanol was recrystallized to give a purple solid product, m.p.> 30 (TC (thermometer untreated).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 84378-94-9, its application will become more common.

Reference:
Patent; Northwest University; Wang, Culing; Liu, Jianli; Zhao, Danqing; Liu, Zhulan; Zhang, Ning; (10 pag.)CN103980182; (2016); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Adding a certain compound to certain chemical reactions, such as: 84378-94-9, name is 4-Chloro-5-fluoroindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 84378-94-9, Computed Properties of C8H3ClFNO2

Anthranilic acid was added 0. Olmol equipped with a reflux condenser, a magnetic sub, thermometer, three-necked flask below, by adding toluene 15mL, dried S0C12 3mL, reflux 1. 0h, to stop the reaction, the solvent was removed by rotary evaporation under reduced pressure and excess the S0C12. Beyond flask square. OlmoL 4-chloro-5-fluoro-isatin and 15mL of dichloromethane, the reaction continued at reflux for 1. 0h, cooled to room temperature and filtered to give a yellow solid, washed with methanol lotions, dichloro recrystallization from toluene or methane. In this method for the synthesis of the following target product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-5-fluoroindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Northwest University; Huo, Baolong; Wang, Cuiling; (52 pag.)CN105330666; (2016); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem