Category: 7477-63-6

These common heterocyclic compound, 7477-63-6, name is 7-Chloroisatin, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 7-Chloroisatin

General procedure: The mixture of isatin (1 mmol), 3-amino-1-phenyl-1H-pyrazol-5(4H)-one (1 mmol), 1,2-diarylethan-1-one, 2,3-dihydroinden-1-one (1 mmol) or 3,4-dihydronaphthalen-1(2H)-one (1 mmol), H2O (6 mL), HOAc (2 mL) was put in a reaction flask under 90 °C about 5-7 h (monitored by TLC). After completion, the reaction mixture was cooled to room temperature and the products would be isolated out at same time. Then, compound 4 was recrystallized from DMF, however, the pure products of 6 and 8 were filtered from water, dried, without further recrystallization.

The synthetic route of 7-Chloroisatin has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Zhansheng; Gao, Lingli; Xu, Zhongyun; Ling, Zhi; Qin, Yaqi; Rong, Liangce; Tu, Shu-Jiang; Tetrahedron; vol. 73; 4; (2017); p. 385 – 394;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7477-63-6, name is 7-Chloroisatin, A new synthetic method of this compound is introduced below., Formula: C8H4ClNO2

General procedure: The mixture of isatin (1 mmol), 3-amino-1-phenyl-1H-pyrazol-5(4H)-one (1 mmol), 1,2-diarylethan-1-one, 2,3-dihydroinden-1-one (1 mmol) or 3,4-dihydronaphthalen-1(2H)-one (1 mmol), H2O (6 mL), HOAc (2 mL) was put in a reaction flask under 90 °C about 5-7 h (monitored by TLC). After completion, the reaction mixture was cooled to room temperature and the products would be isolated out at same time. Then, compound 4 was recrystallized from DMF, however, the pure products of 6 and 8 were filtered from water, dried, without further recrystallization.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Wang, Zhansheng; Gao, Lingli; Xu, Zhongyun; Ling, Zhi; Qin, Yaqi; Rong, Liangce; Tu, Shu-Jiang; Tetrahedron; vol. 73; 4; (2017); p. 385 – 394;,
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Related Products of 7477-63-6,Some common heterocyclic compound, 7477-63-6, name is 7-Chloroisatin, molecular formula is C8H4ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Mg(ClO4)2 (10 mol percent) was added to a mixture of isatin (2 mmol), malononitrile or ethyl cyanoacetate (2mmol), and dimedone (2 mmol) in aqueous ethanol solution(50percent, v/v, 5 mL), and the resulting mixture was stirred at 50°C for 30-60 min. Upon completion of the reaction (TLC),the mixture was allowed to cool to room temperature. The resulting solid was filtered and washed successively with water (2 × 30 mL) and cold aqueous ethanol (2 × 1 mL) to afford pure product 4.

The synthetic route of 7477-63-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wu, Chunlei; Shen, Runpu; Chen, Jianhui; Hu, Chunqi; Bulletin of the Korean Chemical Society; vol. 34; 8; (2013); p. 2431 – 2435;,
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These common heterocyclic compound, 7477-63-6, name is 7-Chloroisatin, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 7-Chloroisatin

General procedure: In sealed tube, a solution of 3 mL solvent (DMSO or DMF) of hydrazines 1 (0.5mmol), diketones 2 or 4 (0.5mmol), K2CO3 (1mmol), eosin Y (0.025mmol) was sequentially added. The reaction mixture was stirred under incandescent light (0.4 Wcm-2) irradiation at 45 °C for 24 h. Then, the mixture extracted with ethyl acetate (3 × 10 mL), and the organic layer was combined and dried with anhydrous Na2SO4. After removal of the solvent under reduced pressure, the residue was separated by flash column chromatography to afford the pure product 3 or 5 (PE: EA = 20:1).

The synthetic route of 7-Chloroisatin has been constantly updated, and we look forward to future research findings.

Reference:
Article; Diao, Pinhui; Ge, Yanqin; zhang, Wenpei; Xu, Chen; Zhang, Nannan; Guo, Cheng; Tetrahedron Letters; vol. 59; 8; (2018); p. 767 – 770;,
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7477-63-6, name is 7-Chloroisatin, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C8H4ClNO2

General procedure: To a mixture of isatin or isatin derivatives (1 mmol) in DMF (1.5 mL) was added dried K2CO3 (165.5 mg, 1.2 mmol). The resulting mixture was stirred at 70oC for 1 hour, then 83 mg of KI (0.5 mmol) was added followed by slow addition of a solution of 3,4,5-trimethoxybenzyl clorid (216.7 mg, 1 mmol) in DMF (1 mL). The reaction mixture was stirred for a further 3 hours at 80oC, then cooled to room temperature. Cold water (20 mL) was slowly added to the cooled reaction mixture and pH was adjusted to ~ 6 by a solution of HCl 5percent to generate yellowish to brown precipitates, which were filtered, washed by cold water until neutrality. The precipitates were recrystallized by EtOH/H2O and dried at 60oC under vacuum.

The synthetic route of 7477-63-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Huan, Le Cong; Pham-The, Hai; Le-Thi-Thu, Huong; Thao, Tran Phuong; Que, Do Nguyet; Trang, Nguyen-Thu; Dung, Phan Thi Phuong; Pyo, Minji; Han, Sang-Bae; Thuan, Nguyen Thi; Nam, Nguyen-Hai; Letters in drug design and discovery; vol. 15; 4; (2018); p. 375 – 387;,
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Adding a certain compound to certain chemical reactions, such as: 7477-63-6, name is 7-Chloroisatin, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7477-63-6, SDS of cas: 7477-63-6

General procedure: To the respective solution of isatins 1a-g (1 mmol) inDMF(3mL) were added K2CO3 (165.5mg, 1.2 mmol). The resultingmixtures were stirred at 80 C for 1 h, then KI (8.3 mg,0.05 mmol) was added. After stirring for further 15 min,0.15mL of a solution of propargyl bromide 80% in toluenewas added dropwise slowly into the mixtures. The reactionmixtures were again stirred at 60 C for 3 h. Upon completionof the reaction, the resulting mixtures were cooled, pouredinto ice-cold water and acidified to pH?4. The orange solidsformed were filtered and dried to give the propargylatedisatins2, which were used for the next step without furtherpurification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Chloroisatin, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Dung, Do Thi Mai; Hai, Pham-The; Anh, Duong Tien; Huong, Le-Thi-Thu; Yen, Nguyen Thi Kim; Han, Byung Woo; Park, Eun Jae; Choi, Yeo Jin; Kang, Jong Soon; Hue, Van-Thi-My; Han, Sang-Bae; Nam, Nguyen-Hai; Journal of Chemical Sciences; vol. 130; 6; (2018);,
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Some common heterocyclic compound, 7477-63-6, name is 7-Chloroisatin, molecular formula is C8H4ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 7-Chloroisatin

In a 100 mL round bottom flask, according to the feed ratio (7-chloroisatin: ethanol (1:1.5); 7-chloroisatin: 1-phenylmalonaldehyde (1:1.2))Add 7-chloroisatin 80 mg (0.44 mmol), ethanol 30.4 mg (0.66 mmol) and 1-phenylmalonaldehyde 78.4 mg (0.53 mmol), respectively.Adding a catalytic amount (0.1 times equivalent of 7-chloroisatin or its derivative) of 007×7, ferrocene and palladium acetate, 25 mL of solvent tetrahydrofuran, heating to 80 ° C, and heating for 6 hours.The reaction was monitored by thin layer chromatography. After the reaction was completed, the heating was stopped, the condensing device was removed, the mixed system was concentrated under reduced pressure, and purified by column chromatography.The title compound (12) was obtained by drying to give 120.8 mg,yield of 81percent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7477-63-6, its application will become more common.

Reference:
Patent; Shaanxi University of Science and Technology; Liang Chengyuan; Tian Danni; Ding Shunjun; Wang Xuechuan; Dong Hao; Wang Qiang; (15 pag.)CN108395438; (2018); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7477-63-6, name is 7-Chloroisatin belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 7-Chloroisatin

General procedure: A mixture of 5-chloroisatin (1.81 mg,10 mmol), 1-bromobutane (2 mL, 18 mmol) and cesium carbonate (13.03 g, 40 mmol) in dimethylformamide (100 mL) was stirred at room temperature overnight. After extraction with ethyl acetate, the organic layer was washed with hydrochloric acid (0.4 N) and water, dried over MgSO4 and concentrated under vacuum, giving a residue that was washed with a mixture of heptane?ethyl acetate to afford 1-butyl-5-chloroindoline-2,3-dione (2a, 2.13 g, 90percent) as a red solid. The same procedure was used to prepare 2b?d.

The synthetic route of 7477-63-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Reddy, Sanapalli Subba; Pallela, Ramjee; Kim, Dong-Min; Won, Mi-Sook; Shim, Yoon-Bo; Chemical and Pharmaceutical Bulletin; vol. 61; 11; (2013); p. 1105 – 1113;,
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Related Products of 7477-63-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7477-63-6 as follows.

General procedure: A mixture of isatins 1a-f (1 mmol), active cyanomethanes 2a-b (1 mmol), and enolizable ketones 3a-d (1 mmol) in ethanol (3 ml)was stirred at room temperature in the presence of HIL (Scheme 2).The reaction progress was monitored by thin-layer chromatography (TLC). After completion of the reaction, the reaction mixture was treated with ethanol to recover the insoluble catalyst by filtration.The filtrate was then concentrated under vacuum and the desired product was obtained. The structures of the products were confirmed by 1H NMR, IR spectroscopy, and supported by elemental analysis. The filtered catalyst was dried under vacuum for 2 h and was reused with a fresh charge of solvent and reactants for subsequent runs under the same reaction conditions to observe its catalytic efficiency.

According to the analysis of related databases, 7477-63-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Satasia, Shailesh P.; Kalaria, Piyush N.; Avalani, Jemin R.; Raval, Dipak K.; Tetrahedron; vol. 70; 35; (2014); p. 5763 – 5767;,
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Adding a certain compound to certain chemical reactions, such as: 7477-63-6, name is 7-Chloroisatin, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7477-63-6, Computed Properties of C8H4ClNO2

5mmol of o-phenylenediamine in turn,5mmol 7-chlorodione indole,6mmol iodoethane,1mmol p-toluenesulfonic acid,1mmol selective fluorine reagent,20ml of toluene was added to the round bottom flask,Stir at reflux at 70-90 C for 24 hours. After the reaction is complete, add 30 ml of brine to quench the reaction. The reaction mixture is extracted with 90 ml of ethyl acetate three times to extract the reaction product. An analytically pure 7-chloro-6-ethyl-6H-indole [2,3-b] quinoxaline was obtained. Red solid, 81% yield

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-Chloroisatin, and friends who are interested can also refer to it.

Reference:
Patent; South China Normal University; Guangzhou Huarui Optoelectric Materials Co., Ltd.; Song Xinlong; Zhou Guofu; Pan Junyou; (10 pag.)CN110283177; (2019); A;,
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