Application of 6872-06-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6872-06-6 name is 2-Methylindoline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Under the protection of anhydrous oxygen-free and inert gas, 0.01161 g (1.14¡Á10-5 mol) {L1La[N(SiMe3)2]}2 was added to the reaction flask, and then 148 muL (1.14¡Á10-3 mol) 2- Methyl porphyrin was added to 1.41 mL of tetrahydrofuran and stirred at room temperature for 0.5 hour. Further, 0.34 mL (3.40 x 10-3 mol) of benzaldehyde was added, and after the reaction was stirred for 3 hours, the reaction was completed.Pour the reaction solution into an eggplant-shaped bottle, add a small amount of ethyl acetate to the reaction flask and wash it three times, still pour into the eggplant-shaped bottle.Add appropriate amount of silica gel, spin dry, and then load on the packed column of silica gel.The column was passed through a suitable eluent (ethyl acetate: petroleum ether = 1: 6) to afford product, yield 75%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Methylindoline, and friends who are interested can also refer to it.
Reference:
Patent; Soochow University (Suzhou); Zhao Bei; Xiao Yang; Lu Chengrong; (18 pag.)CN104817583; (2019); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem