Category: 6344-05-4

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6344-05-4, name is 4-Chloroisatin belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. 6344-05-4

80 kg of 2- [4- (1,3-dioxo-2-isoindolinol] phenylbutyric acid prepared in the method of Example 1 and 480 L of acetic acid were charged into a reaction vessel, and stirring was started. A mixture of 64 kg Zinc powder into the reaction tank, atmospheric pressure into the hydrogen chloride gas,The reaction temperature was controlled at 82 C, the reaction started, the reaction time was 1 hour, the reaction liquid all clear. Filter, wash the residue with acetic acid, The filtrate and washings were combined, the solvent was removed under reduced pressure, the residue was poured into appropriate amount of water, stirred and adjusted to pH 5.5-6.5 by ammonia water, dried and centrifuged to give 72.3 kg of indobufen crude product with a yield of 94.7% and a purity of 98.0%

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 6344-05-4.

Reference:
Patent; Hangzhou China-USA East China Pharmaceutical Co., Ltd.; Cao Dongsheng; Han Tao; Zhou Hanjun; Yu Rui; (8 pag.)CN106631974; (2017); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

These common heterocyclic compound, 6344-05-4, name is 4-Chloroisatin, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 4-Chloroisatin

EXAMPLE 32 7-Chloroindolo[2,1-b]quinazoline-6,12-dione STR40 Using the procedure in Example 12 and substituting isatoic anhydride for 5-chloroisatoic anhydride and 4-chloroisatin for 5-fluoroisatin gave the title compound in 16percent yield: mp 294°-295.7° C.; 1 H NMR (300 MHz, DMSO-d6) delta 8.49(d, 1H) 8.33 (d, 1H) 7.97 (d, 2H) 7.81-7.90 (m, 1H) 7.72-7.80 (m, 1H) 7.52 (d, 1H); MS (M+H)+ 283.

The synthetic route of 4-Chloroisatin has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PathoGenesis Corporation; US5441955; (1995); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Application of 6344-05-4, These common heterocyclic compound, 6344-05-4, name is 4-Chloroisatin, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To the 25 ml dry round-bottom flask is added in 3 ml toluene, 163 mg (1mmol) isatoic anhydride, 181 mg (1mmol) 4- chloroisatin (purchased from Shanghai the nation becomes chemical Company limited), 505 mg (5mmol) triethylamine, then heating to 110 °C, stir at reflux reaction 3-4h, TLC detection display after the reaction is finished, pressure reducing evaporate solvent, residue is recrystallized in ethanol, to obtain the product 7- chlorine tryptamine alkone 225 mg, yield 80percent.

The synthetic route of 6344-05-4 has been constantly updated, and we look forward to future research findings.

A common heterocyclic compound, 6344-05-4, name is 4-Chloroisatin, molecular formula is C8H4ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 6344-05-4.

80 kg of 2- [4- (1,3-dioxo-2-isoindolinol] phenylbutyric acid prepared in the method of Example 1 and 480 L of acetic acid were charged into a reaction vessel, and stirring was started. A mixture of 64 kg Zinc powder into the reaction tank, atmospheric pressure into the hydrogen chloride gas,The reaction temperature was controlled at 82 C, the reaction started, the reaction time was 1 hour, the reaction liquid all clear. Filter, wash the residue with acetic acid, The filtrate and washings were combined, the solvent was removed under reduced pressure, the residue was poured into appropriate amount of water, stirred and adjusted to pH 5.5-6.5 by ammonia water, dried and centrifuged to give 72.3 kg of indobufen crude product with a yield of 94.7% and a purity of 98.0%

The synthetic route of 4-Chloroisatin has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hangzhou China-USA East China Pharmaceutical Co., Ltd.; Cao Dongsheng; Han Tao; Zhou Hanjun; Yu Rui; (8 pag.)CN106631974; (2017); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem