Category: 611-09-6

Related Products of 611-09-6,Some common heterocyclic compound, 611-09-6, name is 5-Nitroindoline-2,3-dione, molecular formula is C8H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The suspension of isatin 1a-c in hydrazine hydrate was refluxed for 5h until clear solution formation. After reaction completion the mixture was cooled down to room temperature and poured into cold water. Then pH value of the mixture was adjusted to 1-2 via concentrated hydrochloride acid addition. The reaction mixture was left at room temperature for 2-3days, the precipitate formed was filtered, washed with water and dried on air and was used without additional purification. The following compounds were obtained according to this general procedure:

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Nitroindoline-2,3-dione, its application will become more common.

Reference:
Article; Lozinskaya, Natalia A.; Babkov, Denis A.; Zaryanova, Ekaterina V.; Bezsonova, Elena N.; Efremov, Alexander M.; Tsymlyakov, Michael D.; Anikina, Lada V.; Zakharyascheva, Olga Yu.; Borisov, Alexander V.; Perfilova, Valentina N.; Tyurenkov, Ivan N.; Proskurnina, Marina V.; Spasov, Alexander A.; Bioorganic and Medicinal Chemistry; vol. 27; 9; (2019); p. 1804 – 1817;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Related Products of 611-09-6, These common heterocyclic compound, 611-09-6, name is 5-Nitroindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The mixture of the Fe(III)(at)g-C3N4 nanocomposite (70 mg, 0.35 mmol based on Fe(III)) in aqueous media (3 ml) was dispersed for 30 min. Isatin (1 mmol) and indole (2.0 mmol) were added to the mixture and stirred in reflux conditions for an appropriate time. After the reaction was completed, the crude product was extracted with ethyl acetate and dried over anhydrous Na2SO4 followed by evaporation of the solvent. The pure products were achieved by recrystallization in hot ethanol and identified by IR, 1H & 13C NMR spectral data. The nanocomposite was washed with EtOH, dried, and reused for the next run.

Statistics shows that 5-Nitroindoline-2,3-dione is playing an increasingly important role. we look forward to future research findings about 611-09-6.

Reference:
Article; Allahresani, Ali; Taheri, Bahare; Nasseri; Research on Chemical Intermediates; vol. 44; 11; (2018); p. 6741 – 6751;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Related Products of 611-09-6, A common heterocyclic compound, 611-09-6, name is 5-Nitroindoline-2,3-dione, molecular formula is C8H4N2O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of indole (2 mmol), isatin (1 mmol), SAMSNs (0.06 g), and water (3 ml) was stirred at 60 C for different periods of time as indicated in Table 4. After completion of the reaction (as monitored by TLC), the mixture was cooled to room temperature. The precipitated solid and the SAMSNs were filtered off and dissolved in acetone. After dissolution of the product, the solid catalyst was removed by filtration, and the resulting solution was evaporated under reduced pressure. The pure product was obtained by recrystallization from ethanol.

The synthetic route of 611-09-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mehrasbi, Ebrahim; Sarrafi, Yaghoub; Tajbakhsh, Mahmood; Research on Chemical Intermediates; vol. 41; 9; (2015); p. 6777 – 6787;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Application of 611-09-6,Some common heterocyclic compound, 611-09-6, name is 5-Nitroindoline-2,3-dione, molecular formula is C8H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 2 (200mg, 1.04mmol), neopentyl glycol (108mg,1.04mmol) and p-toluenesulfonic acid (25mg, 145mumol) were suc-cessively added and dissolved in cyclohexane (10mL). The resulting reaction mixture was refluxed for 16 h at 85 C. After completion of the reaction, the mixture was cooled to room temperature. Then, the pre-cipitate was filtered ,washed with water and dried .Purification by chromatography on silica gel (petroleum ether/ethyl acetate=5/1)afforde dintermediate3.White solid; yield 84%; mp: 201-203C; 1 H NMR (400MHz,DMSO-d 6 ) delta 11.20 (s, 1H), 8.28 (dd, J=8.7, 2.4Hz, 1H), 8.08 (d,J=2.4Hz, 1H), 7.04 (d, J=8.7Hz, 1H), 4.49 (d, J=11.0Hz, 2H),3.55 (d, J=11.2Hz, 2H), 1.34 (s, 3H), 0.84 (s, 3H).

The synthetic route of 611-09-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yu, Shengping; Liu, Yang; Zhang, Zhen; Zhang, Jingya; Zhao, Guisen; Bioorganic and Medicinal Chemistry; vol. 27; 15; (2019); p. 3319 – 3327;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Electric Literature of 611-09-6, These common heterocyclic compound, 611-09-6, name is 5-Nitroindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: First, 0.01g of the CoFe2O4(at)SiO2(at)SO3H was dispersed for 30min and after that an amount of 1mmol from isatin, malononitrile and dimedone with ethanol/water (ratio 1:1) were mixed, and the final mixture was placed in 80C at the reflux condition. After completing the reaction by passing a certain time, the con -taining solution was separated by centrifuging and the crude product extracted and washed with ethyl acetate, and then Na 2 SO 4 was added to dehydrating the product. After that, the solvent was removed by using a rotary evaporator and finally the product recrystallized in hot ethanol to gain the pure product. Moreo -ver, the catalyst was washed and applied for several times to examine reusability. Structural assignments of the products are based on their 1 HNMR, 13 CNMR and IR spectra.

Statistics shows that 5-Nitroindoline-2,3-dione is playing an increasingly important role. we look forward to future research findings about 611-09-6.

Reference:
Article; Zamani-Ranjbar-Garmroodi, Bardia; Nasseri, Mohammad A.; Allahresani, Ali; Hemmat, Kaveh; Research on Chemical Intermediates; vol. 45; 11; (2019); p. 5665 – 5680;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Electric Literature of 611-09-6,Some common heterocyclic compound, 611-09-6, name is 5-Nitroindoline-2,3-dione, molecular formula is C8H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of L-proline-melamine complex (3 mol%) in DMSO (2 mL) was added dimedone 0.025 mg (0.178 mmol), malononitrile (1 equiv) and benzaldehyde / isatin (1 equiv) and stirred at room temperature for 1-20 min. After completion of the reaction (monitored by TLC), ethyl acetate was added stirring and continued for another 5 min. The precipitate formed was filtered. Evaporation of solvent gave the crude product which was recrystallized using ethanol to give the pure compound.

The synthetic route of 611-09-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Nagaraju, Sakkani; Paplal, Banoth; Sathish, Kota; Giri, Santanab; Kashinath, Dhurke; Tetrahedron Letters; vol. 58; 44; (2017); p. 4200 – 4204;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Reference of 611-09-6,Some common heterocyclic compound, 611-09-6, name is 5-Nitroindoline-2,3-dione, molecular formula is C8H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of acetophenone or isatin (5 mmol) in THF (10 mL), BF3¡¤OEt2 (7.5 mmol) was added at 0C under the atmosphere of N2 and the mixture was stirred for 10 minutes. To the cooled mixture, anhydrous hydrazine (7.5 mmol) was added in one portion and the reaction mixture was stirred at 0C under the atmosphere of N2 for 30 min. The reaction was quenched by the addition of a saturated solution of NH4Cl (4 mL), extracted by ethyl acetate (3 ¡Á 15 mL) and purified by column chromatography (ethyl acetate-CH2Cl2; 3 : 7) to afford hydrazones 2-22.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Nitroindoline-2,3-dione, its application will become more common.

Reference:
Article; El-Azab; Ghabbour; El-Husseiny; Maarouf; Mohamed; Abdel-Aziz; Russian Journal of General Chemistry; vol. 86; 12; (2016); p. 2837 – 2844; Zh. Obshch. Khim.; vol. 86; 12; (2016); p. 2837 – 2844,8;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Adding a certain compound to certain chemical reactions, such as: 611-09-6, name is 5-Nitroindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 611-09-6, Safety of 5-Nitroindoline-2,3-dione

General procedure: A mixture of isatin derivatives (1a-1d, 1 mmol) oracenaphthoquinone (5, 1 mmol), methylene nitriles (2a,2b, 1 mmol), 1,3-dicarbonyl (3, 1 mmol), and 5 mg IG in3 cm3 H2O was stirred at 60 C for the mentioned timeshown in tables. Rapid conversion of reagents can beclearly confirmed by reaction color change. The progress ofthe reaction was monitored by TLC using EtOAc/n-hexane(1:3) as an eluent. Upon completion, the reaction mixturewas allowed to cool to room temperature and the precipitatewas obtained from the reaction mixture by filtration.The product 4a was dissolved in DMSO and the catalystwas separated by simple filtration. Pure products wereafforded by evaporation of the solvent under reduced pressure.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Nitroindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Javanshir, Shahrzad; Saghiran Pourshiri, Nassim; Dolatkhah, Zahra; Farhadnia, Mohammad; Monatshefte fur Chemie; vol. 148; 4; (2017); p. 703 – 710;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

These common heterocyclic compound, 611-09-6, name is 5-Nitroindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 611-09-6

General procedure: The mixture of the Fe(III)(at)g-C3N4 nanocomposite (70 mg, 0.35 mmol based on Fe(III)) in aqueous media (3 ml) was dispersed for 30 min. Isatin (1 mmol) and indole (2.0 mmol) were added to the mixture and stirred in reflux conditions for an appropriate time. After the reaction was completed, the crude product was extracted with ethyl acetate and dried over anhydrous Na2SO4 followed by evaporation of the solvent. The pure products were achieved by recrystallization in hot ethanol and identified by IR, 1H & 13C NMR spectral data. The nanocomposite was washed with EtOH, dried, and reused for the next run.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 611-09-6.

Reference:
Article; Allahresani, Ali; Taheri, Bahare; Nasseri; Research on Chemical Intermediates; vol. 44; 11; (2018); p. 6741 – 6751;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem