Category: 611-09-6

Synthetic Route of 611-09-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 611-09-6, name is 5-Nitroindoline-2,3-dione, This compound has unique chemical properties. The synthetic route is as follows.

Intermediate 2 (200 mg, 1.04 mmol), neopentyl glycol (108 mg, 1.04 mmol), p-toluenesulfonic acid (25 mg, 145 mumol) were added to cyclohexane (10 ml), a water separator of the reaction device and a reflux condenser The reaction was refluxed for 16 h. The reaction produced a white solid insoluble in cyclohexane. The reaction was detected by TLC. The solid product was filtered, the solid product was washed with water, dried, and then subjected to silica gel column chromatography (petroleum ether: ethyl acetate = 5: 1). The product was recrystallized from acetonitrile to obtain 243 mg of white needle crystals. Yield: 84%.

The chemical industry reduces the impact on the environment during synthesis 5-Nitroindoline-2,3-dione. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Shandong University; Zhao Guisen; Zhang Zhen; Zhang Qian; Zhang Jingya; (39 pag.)CN110734391; (2020); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Adding a certain compound to certain chemical reactions, such as: 611-09-6, name is 5-Nitroindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 611-09-6, COA of Formula: C8H4N2O4

A mixture of 5-nitroisatin 22a (5.0 g, 26.0 mmol), 2, 2′-dimethylpropane-1, 3-diol (2.69 g, 25.9 mmol) and a catalytic amount ofp-TSA was suspended in cyclohexane (35 mL) and refluxed with azeotropic removal of water using Dean-Stark apparatus, overnight. The reaction mixture was cooled to room temperature and the solid that separeted was filtered, washed with dilute aqueous sodium bicarbonate, water and then air dried to give 22b. Yield 6. 5g, 90%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Nitroindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE ROCKEFELLER UNIVERSITY; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; WO2005/41954; (2005); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Electric Literature of 611-09-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 611-09-6, name is 5-Nitroindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Isatin 1 (3 mmol), malononitrile (0.2 g, 3 mmol,), bicyclic CH-acid 2 (3 mmol) and sodium acetate (0.025 g, 0.3 mmol) in ‘solvent-free’ manner or with additive (‘on-solvent’ manner) were grinded with a pestle and mortar at ambient temperature for 15 minutes. After the reaction was finished, the mixture was air-dried. Then the crude solid was put on filter, rinsed with water (2 mL) and EtOH (2 mL), and then dried with a water pump to isolate the spiro-oxindole 3.

The synthetic route of 5-Nitroindoline-2,3-dione has been constantly updated, and we look forward to future research findings.

Reference:
Article; Elinson, Michail N.; Vereshchagin, Anatoly N.; Ryzhkov, Fedor V.; Anisina, Yuliya E.; Arkivoc; vol. 2018; 4; (2018);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Reference of 611-09-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 611-09-6, name is 5-Nitroindoline-2,3-dione, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of substituted isatins (1 mmol),cyclic 1,3-diketone (1 mmol), malononitrile (1 mmol)and nano Ag/kaolin (0.085 g, 7 mol%) in EtOH (10mL) was stirred at reflux temperature. Uponcompletion instead of compilation, monitored by TLC(n-hexane/ethyl acetate: 2/1), the reaction mixture wasallowed to cool to room temperature. The catalyst wasseparated by filtration of this solution. The solution wasconcentrated under vacuum to afford the product,which was purified by recrystallization in the ethanol.All the products were identified by comparing of meltingpoint and 1H NMR spectra with those of authenticsamples reported in the literature.

The chemical industry reduces the impact on the environment during synthesis 5-Nitroindoline-2,3-dione. I believe this compound will play a more active role in future production and life.

Reference:
Article; Sadeghi, Bahareh; Lasemi, Zahra; Azimi, Razieh; Oriental Journal of Chemistry; vol. 31; 2; (2015); p. 1175 – 1179;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Adding a certain compound to certain chemical reactions, such as: 611-09-6, name is 5-Nitroindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 611-09-6, SDS of cas: 611-09-6

General procedure: The mixture of the Fe(III)(at)g-C3N4 nanocomposite (70 mg, 0.35 mmol based on Fe(III)) in aqueous media (3 ml) was dispersed for 30 min. Isatin (1 mmol) and indole (2.0 mmol) were added to the mixture and stirred in reflux conditions for an appropriate time. After the reaction was completed, the crude product was extracted with ethyl acetate and dried over anhydrous Na2SO4 followed by evaporation of the solvent. The pure products were achieved by recrystallization in hot ethanol and identified by IR, 1H & 13C NMR spectral data. The nanocomposite was washed with EtOH, dried, and reused for the next run.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Allahresani, Ali; Taheri, Bahare; Nasseri; Research on Chemical Intermediates; vol. 44; 11; (2018); p. 6741 – 6751;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Application of 611-09-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 611-09-6 as follows.

General procedure: A mixture of malononitrile (1 mmol), isatin (1 mmol), dicarbonyl (1 mmol), PEGOSO3H(0.1 mmol), and water (2 mL) was stirred under reflux for the appropriate time (shown in Tables 3, 4). After completion of the reaction, the reaction mixture was filtered and the residue was washed with ethanol. The crude solid product was recrystallized from EtOH to afforded the pure products in high purity and yield.Assignment of the structures of the products was based on their 1H NMR, 13C NMR,and IR spectra.

According to the analysis of related databases, 611-09-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Nasseri; Zakerinasab; Research on Chemical Intermediates; vol. 41; 8; (2015); p. 5261 – 5270;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 611-09-6, name is 5-Nitroindoline-2,3-dione, A new synthetic method of this compound is introduced below., Safety of 5-Nitroindoline-2,3-dione

General procedure: A mixture of an isatin (1mmol), molononitrile (1mmol), CH activatedacid (1mmol), and [C4(DABCO)2]¡¤2OH(2mol%) inwater (3mL)was stirred at 80 C. The reaction progress was monitored by TLC [eluent:n-hexane:EtOAc (9:2)] (It is important to that by beginning of thereaction the products were precipitated in the reaction medium).After completion of the reaction, the mixture was cooled to room temperature and the solid product was filtered, washed with cold distilledwater (2 mL) to obtain essentially pure products. The solid productswere recrystallized from ethanol if necessary.

The synthetic route of 611-09-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Goli-Jolodar, Omid; Shirini, Farhad; Seddighi, Mohadeseh; Journal of Molecular Liquids; vol. 224; (2016); p. 1092 – 1101;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Related Products of 611-09-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 611-09-6 name is 5-Nitroindoline-2,3-dione, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The SiO2/g-C3N4 nanocomposite (25 mg) was dispersed in water (3 ml) for 30 min. Indole (2.0 mmol), and isatin (1.0 mmol) were added to the mixture which was stirred for the appropriate time. The progress of the reaction was monitored by thin layer chromatography. After the completion of the reaction, the crude product was extracted with ethyl acetate and dried over anhydrous Na2SO4. Then, the crude product was recrystallized in hot ethanol. The SiO2/g-C3N4 nanocatalyst was recovered from the aqueous layer by centrifuging, washed with EtOH, dried and reused for the next run.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Nitroindoline-2,3-dione, and friends who are interested can also refer to it.

Reference:
Article; Allahresani, Ali; Nasseri, Mohammad Ali; Nakhaei, Alireza; Research on Chemical Intermediates; vol. 43; 11; (2017); p. 6367 – 6378;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 611-09-6, name is 5-Nitroindoline-2,3-dione, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 5-Nitroindoline-2,3-dione

General procedure: To a mixture containing isatin derivatives (1 mmol),malononitrile or ethyl cynocette (1mmol) and 1,3-cyclldiketone (1 mmol) in water (5 mL), H-Fe3O4(at)DA-SO3H(0.01g) were added and stirred under reflux condition. The progress of the reaction was monitored by TLC (n-hexane:EtOAc 7:3). After completion of the reaction the mixture was cooled and the catalyst was separated by means of an external magnet from mixture, then the crude product was collected and washed with distilled water and dried. They were weighted for reporting of the yields.

According to the analysis of related databases, 611-09-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Mirhosseyni, Marzie Sadat; Nemati, Firouzeh; Elhampour, Ali; Combinatorial Chemistry and High Throughput Screening; vol. 21; 7; (2018); p. 487 – 494;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

611-09-6, name is 5-Nitroindoline-2,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 611-09-6

General procedure: To a solution of isatins 4a-h (1 mmol) and TiO2 NPs (8 mg, 0.1 mmol, 10 mol%) in water (3 mL), indoles 5a-d (2 mmol) were added and stirred for the indicated time(Table 2) at room temperature. The progress of the reaction was monitored by TLC, however, the same can be inferred by visualizing the disappearance of isatin color and white solid formation. After the consumption of starting material, as indicated by theTLC, the reaction mixture was filtered and the white solid was dried. The obtained solid was then dissolved in ethyl acetate (5 mL) and centrifuged for 1 h at 15000 rpm to separate nanoparticles. Later organic layer was passed through celite pad to remove any particulate impurities from the product and concentrated under reduced pressure. The product was further purified by recrystallization using methanol to give analytically pure 3,3-di(indolyl)indolin-2-ones 6a-r as solid.

The synthetic route of 611-09-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Dwivedi, Kartikey Dhar; Marri, Sameer Reddy; Nandigama, Satish Kumar; Chowhan, L. Raju; Synthetic Communications; vol. 48; 20; (2018); p. 2695 – 2707;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem