Category: 59-48-3

These common heterocyclic compound, 59-48-3, name is Indolin-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 59-48-3

To a solution of oxindole (26 g) in 100 mL of concentrated sulfuric acid at -15 C. was added fuming nitric acid (8.4 mL) dropwise. Careful attention was paid to maintain the reaction temperature at -15 C. After the addition was complete, the reaction was stirred for 30 minutes and then poured into ice water. A yellow precipitate was formed which was isolated by filtration to provide 34 grams (98%) of 5-nitro oxindole.

The synthetic route of Indolin-2-one has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pfizer Inc; US2005/256144; (2005); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59-48-3, name is Indolin-2-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Safety of Indolin-2-one

Sodium hydride (9.0 g; 0.2 mol, 60% in mineral oil) was added portion-wise to a solution of oxindole (10.0 g, 75 mmol) in of dry DMF (350 mL). After 15 minutes, the reaction was cooled to 0 C. and 1,4 dibromoethane in 100 mL of dry DMF was added over 15 minutes. The dark brown reaction was allowed to warm to room temperature and stirred overnight. The reaction was diluted with ethyl acetate and water was added. The layers were separated and the organic layer was dried over anhydrous sodium sulfate. The organic layer was filtered, concentrated in vacuo to give 20 g of red oil. The crude product was purified on silica using a stepwise gradient of 10% to 20% ethyl acetate: hexane to afford Spiro[cyclopropane-1,3′-[3H]indol]-2′(1’H)-one (2.3 g, 11%).

The synthetic route of 59-48-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Wyeth; US2006/30615; (2006); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

These common heterocyclic compound, 59-48-3, name is Indolin-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: Indolin-2-one

To a solution of 1,3-Dihydro-indol-2-one (20 g, 133.15 mmol) in acetonitrile (300 ml) at 0 C. was added NBS (30.76 gm, 173.8 mmol) in several portions and the solution stirred at this temperature for 3 h. Water was added to the reaction mixture, upon which a white solid precipitated. The solid was collected by filtration, washed with hot water and dried under vacuum to obtain compound 5-Bromo-1,3-dihydro-indol-2-one (28 g, 88%).

The synthetic route of Indolin-2-one has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Alam, Muzaffar; Du Bois, Daisy Joe; Hawley, Ronald Charles; Kennedy-Smith, Joshua; Minatti, Ana Elena; Palmer, Wylie Solang; Silva, Tania; Wilhelm, Robert Stephen; US2011/71150; (2011); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 59-48-3, Name is Indolin-2-one, molecular formula is , belongs to indolines-derivatives compound. In a document, author is Filatov, Vadim, Computed Properties of C8H7NO.

Synthesis of 1,3-diaryl-spiro[azetidine-2,3 ‘-indoline]-2 ‘,4-diones via the Staudinger reaction: cis- or trans-diastereoselectivity with different addition modes

A new synthetic approach for realizing biologically relevant bis-aryl spiro[azetidine-2,3 ‘-indoline]-2 ‘,4-diones was developed based on Staudinger ketene-imine cycloaddition through the one-pot reaction of substituted acetic acids and Schiff bases in the presence of oxalyl chloride and an organic base. A series of [azetidine-2,3 ‘-indoline]-2 ‘,4-diones were synthesized using this method. For comparison, the same compounds were obtained using a known technique, where ketene is generated from pre-synthesized acyl chloride. It was shown that the use of oxalyl chloride for ketene generation in the one-pot reaction at room temperature allows for the reversal of the diastereoselectivity of spiro-lactam formation, unlike previously described procedures.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 59-48-3, in my other articles. Computed Properties of C8H7NO.

Related Products of 59-48-3, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 59-48-3, Name is Indolin-2-one, SMILES is O=C1NC2=C(C=CC=C2)C1, belongs to indolines-derivatives compound. In a article, author is Wang, Bing-Wei, introduce new discover of the category.

Efficient One-Pot Synthesis of Spiro[Indoline-3,11′-Pyrazolo[3,4-a]Acridine]-2,10′(1’H)-Dione Derivatives Catalyzed by L-Proline

An efficient eco-friendly procedure for the synthesis of spiro[indoline-3,11′-pyrazolo[3,4-a]acridine]-2,10′(1’H)-dione derivatives has been developed through a one-pot three-component condensation of 1H-indazol-6-amine, isatin, and 5,5-dimethyl cyclohexane-1,3-dione or cyclohexane-1,3-dione, in the presence of catalytic amount L-proline in EtOH at 60 degrees C conditions. The advantages of this protocol include mild reaction condition, green, and nontoxic solvent, high yield, and operational simplicity. IR, H-1 NMR, C-13 NMR, HRMS spectras, and elemental analyses were used to identify the structures of all the synthesized compounds.

Related Products of 59-48-3, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 59-48-3.

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 59-48-3, Name is Indolin-2-one, molecular formula is C8H7NO, belongs to indolines-derivatives compound, is a common compound. In a patnet, author is Kumar, Arvind, once mentioned the new application about 59-48-3, Computed Properties of C8H7NO.

A Smartphone-Assisted Sensitive, Selective and Reversible Recognition of Copper Ions in an Aqueous Medium

A photochromic substituted spiropyran (8-methoxy-1,3′,3′-trimethylspiro[chromene-2,2’indoline]) was successfully synthesized and its structural integrity was ascertained using spectroscopic methods. Owing to the uniquely positioned methoxy and phenolic groups for potential coordination with a metal ion, it was investigated for the recognition of toxic metal ions. The spiropyran derivative responded to the presence of Cu2+ ions in an aqueous solution by displaying a color change visible to the naked eye (colorless to pink). The color change was witnessed due to the Cu2+ ion-induced transformation of the closed-form (spiro) of the substituted spiropyran derivative into an open merocyanine (MC) form, which complexes the Cu2+ ion. The color change was further used for the quantification of Cu2+ ion concentration in water using a smartphone captured digital images via pixel intensity analysis. The spiropyran derivative displayed 0.24 +/- 0.01 mu M, 0.65 +/- 0.06 mu M (0.61 +/- 0.06 mu M using paper strips) as the LOD for Cu2+ ions using UV-Visible spectroscopy and digital colorimetry, respectively. The density functional theory (DFT) calculations and Job’s plot supported the formation of a 2 : 1 (H: G) complex between the spiropyran derivative and copper ions. The time-dependent DFT (TD-DFT) investigations were also used to understand the color change during the complex formation, which indicated a good correlation between the experimental and theoretical results at the molecular level.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 59-48-3. The above is the message from the blog manager. Computed Properties of C8H7NO.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 59-48-3, Name is Indolin-2-one, formurla is C8H7NO. In a document, author is Wang, Jian, introducing its new discovery. Recommanded Product: 59-48-3.

Palladium-catalysed dearomative aryl/cycloimidoylation of indoles

The first example of a dearomative palladium-catalysed isocyanide insertion reaction has been developed using functionalized isocyanides as the reaction partner of N-(2-bromobenzoyl)indoles. The imidoyl-palladium intermediate generated by tandem indole double bond/isocyanide insertion reactions could be trapped by intramolecular functional groups such as the C(sp(2))-H bond and alkenes, affording diversified indoline derivatives bearing C3 imine-containing heterocycles. The dearomative aryl/cycloimidoylation of indoles proceeded smoothly in good to excellent yields with a wide functional group tolerance.

If you are hungry for even more, make sure to check my other article about 59-48-3, Recommanded Product: 59-48-3.

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 59-48-3, Name is Indolin-2-one, molecular formula is C8H7NO, belongs to indolines-derivatives compound, is a common compound. In a patnet, author is Srivastava, Krishna, once mentioned the new application about 59-48-3, Quality Control of Indolin-2-one.

Synthesis and characterization of new thiazole involving isatin for studying their antimicrobial activity

1-(Substituted-1-ylmethyl)indoline-2,3-dione 1a-c have been synthesized from different types of secondary amine with isatin and formaldehyde in alcohol. The compound 1 have then been converted to the respective compound 2a-g (Z)3-(4-subsitutedphenylimino)-1-(substituted-1-ylmethyl)indolin-2-one by treatment with different types of primary amines. Interaction of compound 2 with thioglycolic acid and chloro acetyl chloride results in cyclization to give compound Spiro isatin derivatives compounds 3a-g. The anti-microbial activity screening of novel spiro isatin substituted compounds have also been carried out.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 59-48-3. The above is the message from the blog manager. Quality Control of Indolin-2-one.

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.59-48-3, Name is Indolin-2-one, SMILES is O=C1NC2=C(C=CC=C2)C1, belongs to indolines-derivatives compound. In a document, author is Yang Zhigang, introduce the new discover, Formula: C8H7NO.

A Reversibly Intramolecular Cyclization Cy5 Optical Probe for Stochastic Optical Reconstruction Microscopy in Live Cell Mitochondria

Single molecule localization microscopy as an advanced optical imaging technique is capable of super-resolution imaging of biological targets with the size below the optical diffraction limit. It is promising to provide powerful tools for the exploration of occurrence mechanism of severe diseases and precisely therapeutic method at single cell/organelle level, which exhibits wide applications in biomedical field. Generally, stochastic optical reconstruction microscopy (STORM) is prominently dependent on large amount of imaging buffers (Redox enzymes) and thiol-containing reagents for the ideal photo-blinking behaviors of optical probes. However, the imaging buffer and thiol-containing reagents are harmful for the live cells, which make it difficult to carry out STORM imaging in live cells. Therefore, it is of significance to exploit new approaches to display STORM imaging in live cells. In this work, we provided a new strategy to facilitate the design of live cell STORM imaging probes with improved photo-blinking mechanism. A new fluorescent pentamethine cyanine probe with a thiol-attachment (SHCH2CH2CH2-) at the N-position of one indoline moiety was synthesized to show spontaneously photo-blinking behavior caused by intramolecular ring-closing/-opening processes. The fluorescent probe is biologically compatible with rare cytotoxicity and suitable for the live cell imaging. The probe can exhibit excellent photo-blinking under the direct illumination of a single laser beam (656 nm) with low power density (200 W.cm(-2) for solution sample and 100 W.cm(-2) for cell sample, respectively), without using any imaging buffer or thiol-chemicals. And the fluorescent probe was used to test cell toxicity with CCK-8, showed almost no cytotoxicity after 24 h incubation. The photo-blinking frames were collected with an electron multiplying charge coupled device (EMCCD, 60 Hz), and different frames were used to pre-treat with ImageJ software and then reconstruct STORM images with a Falcon algorithm to show marked imaging resolution enhancement, compared with wide-field images, which provide a new protocol for biomedical imaging.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 59-48-3 is helpful to your research. Formula: C8H7NO.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Application In Synthesis of Indolin-2-one, 59-48-3, Name is Indolin-2-one, SMILES is O=C1NC2=C(C=CC=C2)C1, in an article , author is Murrey, Tucker L., once mentioned of 59-48-3.

Investigation of Hierarchical Structure Formation in Merocyanine Photovoltaics

Merocyanines (MCs) are a versatile class of small-molecule dyes. Their optoelectronic properties are easily tunable by chemically controlling their donor-acceptor strength, and their structural properties can be tuned by simple side-chain substitution. This manuscript demonstrates a novel series of MCs featuring an indoline donor with varying hydrocarbon side-chain length (from 6 to 12 carbons) and a tert-butyl-thiazole acceptor, labeled InTBT. Bulk heterojunction organic photovoltaics are fabricated with a [6,6]-phenyl-C-61-butyric acid methyl ester (PCBM) acceptor and characterized. Films composed of I8TBT:PCBM and I9TBT:PCBM produced the highest power conversion efficiency of 4.5%, which suggests that the morphology is optimized by controlling the side-chain length. Hierarchical structure formation in InTBT:PCBM films is studied using grazing incidence X-ray diffraction (GIXRD), small-angle neutron scattering (SANS), and atomic force microscopy (AFM). When mixed with PCBM, InTBTs with <= 8 side-chain carbons form pure crystalline domains, while InTBTs with >= 9 side-chain carbons mix well with PCBM. SANS demonstrates that increasing side-chain length increases the InTBT-rich domain size. In addition, a branched hexyl-dodecyl side-chain IHDTBT:PCBM film was studied and found to exhibit the worst-performance organic photovoltaic (OPV) device. The large-branched side chain inhibited mixing between IHDTBT and PCBM resulting in large segregated phases.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 59-48-3, you can contact me at any time and look forward to more communication. Application In Synthesis of Indolin-2-one.