Category: 59-48-3

An article Phosphine-Catalyzed Remote 1,7-Addition for Synthesis of Diene Carboxylates WOS:000526394500004 published article about GAMMA-SUBSTITUTED ALLENOATES; UMPOLUNG ADDITION-REACTION; CROSS-COUPLING REACTION; MORITA-BAYLIS-HILLMAN; DIASTEREOSELECTIVE SYNTHESIS; SEQUENTIAL ANNULATION; BOND FORMATION; 3+2 CYCLOADDITION; MICHAEL ADDITION; DOMINO REACTION in [Feng, Jiaxu; Huang, You] Nankai Univ, Coll Chem, State Key Lab, Tianjin 300071, Peoples R China; [Feng, Jiaxu; Huang, You] Nankai Univ, Coll Chem, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China in 2020.0, Cited 105.0. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3. Product Details of 59-48-3

A phosphine-catalyzed remote 1,7-addition of vinyl allenoates has been developed, providing a series of 1,3-dienes derivatives in high yields (up to 99%) and with good chemo-, regio-, and stereoselectivity. This reaction demonstrated that the introduction of vinyl in allenoates effectively extended reaction types of phosphine-catalyzed nucleophilic addition of allenoates, leading to concise synthesis of diene carboxylates. Notably, the enantioselective variant of this 1,7-addition can also be performed by chiral phosphine catalyst.

Welcome to talk about 59-48-3, If you have any questions, you can contact Feng, JX; Huang, Y or send Email.. Product Details of 59-48-3

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

HPLC of Formula: C8H7NO. In 2020.0 ACS CATAL published article about GAMMA-SUBSTITUTED ALLENOATES; UMPOLUNG ADDITION-REACTION; CROSS-COUPLING REACTION; MORITA-BAYLIS-HILLMAN; DIASTEREOSELECTIVE SYNTHESIS; SEQUENTIAL ANNULATION; BOND FORMATION; 3+2 CYCLOADDITION; MICHAEL ADDITION; DOMINO REACTION in [Feng, Jiaxu; Huang, You] Nankai Univ, Coll Chem, State Key Lab, Tianjin 300071, Peoples R China; [Feng, Jiaxu; Huang, You] Nankai Univ, Coll Chem, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China in 2020.0, Cited 105.0. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3.

A phosphine-catalyzed remote 1,7-addition of vinyl allenoates has been developed, providing a series of 1,3-dienes derivatives in high yields (up to 99%) and with good chemo-, regio-, and stereoselectivity. This reaction demonstrated that the introduction of vinyl in allenoates effectively extended reaction types of phosphine-catalyzed nucleophilic addition of allenoates, leading to concise synthesis of diene carboxylates. Notably, the enantioselective variant of this 1,7-addition can also be performed by chiral phosphine catalyst.

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Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Identification of Small-Molecule Positive Modulators of Calcitonin-like Receptor-Based Receptors published in 2020. Formula: C8H7NO, Reprint Addresses Hay, DL (corresponding author), Univ Auckland, Sch Biol Sci, Auckland 1010, New Zealand.; Flanagan, JU; Hay, MP; Hay, DL (corresponding author), Univ Auckland, Maurice Wilkins Ctr Mol Biodiscovery, Auckland 1010, New Zealand.; Flanagan, JU; Hay, MP (corresponding author), Univ Auckland, Auckland Canc Soc Res Ctr, Auckland 1023, New Zealand.. The CAS is 59-48-3. Through research, I have a further understanding and discovery of Indolin-2-one

Class B G protein-coupled receptors are highly therapeutically relevant but challenges remain in identifying suitable small-molecule drugs. The calcitonin-like receptor (CLR) in particular is linked to conditions such as migraine, cardiovascular disease, and inflammatory bowel disease. The CLR cannot act as a cell-surface receptor alone but rather must couple to one of three receptor activity-modifying proteins (RAMPs), forming heterodimeric receptors for the peptides adrenomedullin and calcitonin gene-related peptide. These peptides have extended binding sites across their receptors. This is one reason why there are few small-molecule ligands that can modulate these receptors. Here we describe small molecules that are able to positively modulate the signaling of the CLR with all three RAMPs but are not active at the related calcitonin receptor. These compounds were selected from a beta-arrestin recruitment screen, coupled with rounds of medicinal chemistry to improve their activity. Translational potential is shown as the compounds can positively modulate cAMP signaling in a vascular cell line model. Binding experiments do not support an extracellular domain binding site; however, molecular modeling reveals potential allosteric binding sites in multiple receptor regions. These are the first small-molecule positive modulators described for the CLR:RAMP complexes.

Formula: C8H7NO. Welcome to talk about 59-48-3, If you have any questions, you can contact Hendrikse, ER; Liew, LP; Bower, RL; Bonnet, M; Jamaluddin, MA; Prodan, N; Richards, KD; Walker, CS; Pairaudeau, G; Smith, DM; Rujan, RM; Sudra, R; Reynolds, CA; Booe, JM; Pioszak, AA; Flanagan, JU; Hay, MP; Hay, DL or send Email.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Quality Control of Indolin-2-one. Authors Vaidya, GN; Nagpure, M; Kumar, D in AMER CHEMICAL SOC published article about in [Vaidya, Gargi Nikhil; Nagpure, Mithilesh; Kumar, Dinesh] Natl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Gandhinagar 382355, Gujarat, India in 2021, Cited 72. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3

A borrowing carbonate-enabled allylic cross-amination reactions employing allylic alcohol were discovered via merging acyl/allyl C-O bonds activation under nickel catalysis. The key component of this protocol is the ability of nickel [Ni(II)-Ni(0)] to execute a relay process via the nucleophilic trapping of the generated acyl Ni complex, resulting from the acyl C-O bond cleavage of dialkyl carbonates, followed by selective allylic C-O bond activations (allylic C-O vs alkyl C-O vs acyl C-O) to yield pi-allyINi-complexes. The finding truly represents Ni-catalyzed green allylic amination reactions under additive(s)-free conditions with excellent chemo- (N vs O), regio- (linear vs branched), and stereoselectivity (E vs Z) with a wide range of fundamentally challenging N-heterocycles and allylic alcohols. The reaction is scalable, does not require harmful reaction media and a globe box, and is successfully applied to the scale-up synthesis of pharmaceuticals (cinnarizine, flunarizine, and naftifine) with promising yields.

Welcome to talk about 59-48-3, If you have any questions, you can contact Vaidya, GN; Nagpure, M; Kumar, D or send Email.. Quality Control of Indolin-2-one

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Recently I am researching about MICROPOROUS ORGANIC POLYMERS; GAS-STORAGE; HYPERCROSSLINKED POLYSTYRENE; LINKED POLYMERS; SURFACE-AREA; INTRINSIC MICROPOROSITY; NANOPOROUS POLYMER; HIGH-PERFORMANCE; BUILDING-BLOCKS; TROGERS BASE, Saw an article supported by the TUBITAK-UMETurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK); National Research Foundation of KoreaNational Research Foundation of Korea [NRF-2017M3A7B4042140]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Sadak, AE; Karakus, E; Chumakov, YM; Dogan, NA; Yavuz, CT. The CAS is 59-48-3. Through research, I have a further understanding and discovery of Indolin-2-one. Quality Control of Indolin-2-one

A hypercrosslinked ultramicroporous and ordered organic polymer network was synthesized from a planar trimer indole building block called triazatruxene (TAT) through anhydrous FeCl3 catalyzed Friedel-Crafts alkylation using methylal as a crosslinker. The polymer network is stable in a variety of chemicals and thermally durable. The hypercrosslinked network TATHCP shows a high BET (Brunauer-Emmet-Teller) specific surface area of 997 m(2) g(-1) with CO2 uptake capacity of 12.55 wt % at 273 K, 1.1 bar. Gas selectivities of 38.4 for CO2/N-2, 7.8 for CO2/CH4, 40.6 for CO2/O-2, and 32.1 for CO2/CO were achieved through IAST calculation. The PXRD analysis has revealed that TATHCP has a fully eclipsed structure in full agreement with Pawley refinement. The ordered 2D layers provide anisotropy that could be used in catalysis and thermoelectric measurements. After loading with Pd(II), TATHCP-Pd showed high catalytic activity in Suzuki-Miyaura cross coupling reaction with a wide range of reagents and excellent reaction yields of 90-98% with good recyclability. The structure of TATHCP-Pd was found to have two independent molecules of Pd(OAc)(2) in the asymmetric unit cell which are arranged between two TATHCP layers. Thermoelectric properties of TATHCP showed a high Seebeck coefficient and ZT, a first and promising example in HCPs with applications in all-organic thermal energy recovery devices.

Quality Control of Indolin-2-one. Bye, fridends, I hope you can learn more about C8H7NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Quality Control of Indolin-2-one. In 2020.0 ACS APPL ENERG MATER published article about MICROPOROUS ORGANIC POLYMERS; GAS-STORAGE; HYPERCROSSLINKED POLYSTYRENE; LINKED POLYMERS; SURFACE-AREA; INTRINSIC MICROPOROSITY; NANOPOROUS POLYMER; HIGH-PERFORMANCE; BUILDING-BLOCKS; TROGERS BASE in [Sadak, Ali Enis; Karakus, Erman] TUBITAK UME, Chem Grp Labs, TR-41470 Kocaeli, Turkey; [Chumakov, Yurii M.] Gebze Tech Univ, Dept Phys, TR-41400 Kocaeli, Turkey; [Dogan, Nesibe A.; Yavuz, Cafer T.] Korea Adv Inst Sci & Technol KAIST, Dept Chem & Biomol Engn, Daejeon 34141, South Korea in 2020.0, Cited 74.0. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3.

A hypercrosslinked ultramicroporous and ordered organic polymer network was synthesized from a planar trimer indole building block called triazatruxene (TAT) through anhydrous FeCl3 catalyzed Friedel-Crafts alkylation using methylal as a crosslinker. The polymer network is stable in a variety of chemicals and thermally durable. The hypercrosslinked network TATHCP shows a high BET (Brunauer-Emmet-Teller) specific surface area of 997 m(2) g(-1) with CO2 uptake capacity of 12.55 wt % at 273 K, 1.1 bar. Gas selectivities of 38.4 for CO2/N-2, 7.8 for CO2/CH4, 40.6 for CO2/O-2, and 32.1 for CO2/CO were achieved through IAST calculation. The PXRD analysis has revealed that TATHCP has a fully eclipsed structure in full agreement with Pawley refinement. The ordered 2D layers provide anisotropy that could be used in catalysis and thermoelectric measurements. After loading with Pd(II), TATHCP-Pd showed high catalytic activity in Suzuki-Miyaura cross coupling reaction with a wide range of reagents and excellent reaction yields of 90-98% with good recyclability. The structure of TATHCP-Pd was found to have two independent molecules of Pd(OAc)(2) in the asymmetric unit cell which are arranged between two TATHCP layers. Thermoelectric properties of TATHCP showed a high Seebeck coefficient and ZT, a first and promising example in HCPs with applications in all-organic thermal energy recovery devices.

Quality Control of Indolin-2-one. Welcome to talk about 59-48-3, If you have any questions, you can contact Sadak, AE; Karakus, E; Chumakov, YM; Dogan, NA; Yavuz, CT or send Email.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

An article Selective C3-alkenylation of oxindole with aldehydes using heterogeneous CeO2 catalyst WOS:000531430200008 published article about ENANTIOSELECTIVE CONSTRUCTION; AMIDES; NITRILES; ALCOHOLS; ESTERS; ACTIVATION; HYDRATION; VERSATILE; ISATIN in [Rashed, Md Nurnobi; Touchy, Abeda Sultana; Jeon, Jaewan; Siddiki, S. M. A. Hakim; Toyao, Takashi; Shimizu, Ken-ichi] Hokkaido Univ, Inst Catalysis, N-21,W-10, Sapporo, Hokkaido 0010021, Japan; [Chaudhari, Chandan] Nagoya Univ, Grad Sch Engn, Dept Chem Syst Engn, Nagoya, Aichi 4648603, Japan; [Toyao, Takashi; Shimizu, Ken-ichi] Kyoto Univ, Elements Strategy Initiat Catalysts & Batteries, Kyoto 6158520, Japan in 2020.0, Cited 39.0. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3. Recommanded Product: 59-48-3

We report herein that a commercially available CeO2 is an active and reusable catalyst for the C3-selective alkenylation of oxindole with aldehydes under solvent-free conditions. This. catalytic method is generally applicable to different aromatic and aliphatic aldehydes, giving 3-alkyledene-oxindoles in high yields (87%-99%) and high stereoselectivities (79%-93% to E-isomers). This is the first example of the catalytic synthesis of 3-alkenyl-oxindoles from oxindole and various aliphatic aldehydes. The Lewis acid-base interaction between Lewis acid sites on CeO2 and benzaldehyde was studied by in situ IR. The structure-activity relationship study using CeO2 catalysts with different sizes suggests that defect-free CeO2 surface is the active site for this reaction. (C) 2020, Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.

Recommanded Product: 59-48-3. Bye, fridends, I hope you can learn more about C8H7NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Quality Control of Indolin-2-one. In 2020.0 ANGEW CHEM INT EDIT published article about CROSS-COUPLING REACTIONS; FUNCTIONALIZATION; DERIVATIVES; OXINDOLES; ETHERS; BONDS; PHOTOSENSITIZERS; HYDROCARBONS; ACTIVATION; ANNULATION in [Hu, Ren-Ming; Han, Dong-Yang; Li, Ning; Huang, Jie; Feng, Yu; Xu, Da-Zhen] Nankai Univ, State Key Lab, Coll Chem, Natl Engn Res Ctr Pesticide Tianjin, Tianjin 300071, Peoples R China; [Hu, Ren-Ming; Han, Dong-Yang; Li, Ning; Huang, Jie; Feng, Yu; Xu, Da-Zhen] Nankai Univ, Inst Elementoorgan Chem, Coll Chem, Tianjin 300071, Peoples R China in 2020.0, Cited 61.0. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3.

Presented herein is the first direct alkylation and hydroxylation reaction between two different C(sp(3))-H bonds, indolin-2-ones and alkyl-substituted N-heteroarenes, through an oxidative cross-coupling reaction. The reaction is catalyzed by a simple iron salt under mild ligand-free and base-free conditions. The reaction is environmentally benign, employs air (molecular oxygen) as the terminal oxidant and oxygen source for the synthesis of O-containing compounds, and produces only water as the byproduct.

Quality Control of Indolin-2-one. Welcome to talk about 59-48-3, If you have any questions, you can contact Hu, RM; Han, DY; Li, N; Huang, J; Feng, Y; Xu, DZ or send Email.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

In 2019 ADV SYNTH CATAL published article about SECONDARY AMIDES; N-ALKYLATION; CHEMOSELECTIVE REDUCTION; TERTIARY AMIDES; ACID; DERIVATIVES; CHEMISTRY; NITRILES; ESTERS; CARBON in [Pan, Yixiao; Luo, Zhenli; Xu, Xin; Zhao, Haoqiang; Han, Jiahong; Xu, Lijin] Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China; [Fan, Qinghua] Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China; [Xiao, Jianliang] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England in 2019, Cited 59. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3. Formula: C8H7NO

A ruthenium(II)-catalyzed deoxygenative transfer hydrogenation of amides to amines using HCO2H/NEt3 as the reducing agent is reported for the first time. The catalyst system consisting of [Ru(2-methylallyl)(2)(COD)], 1,1,1-tris(diphenylphosphinomethyl) ethane (triphos) and Bis(trifluoromethane sulfonimide) (HNTf2) performed well for deoxygenative reduction of various secondary and tertiary amides into the corresponding amines in high yields with excellent selectivities, and exhibits high tolerance toward functional groups including those that are reduction-sensitive. The choice of hydrogen source and acid co-catalyst is critical for catalysis. Mechanistic studies suggest that the reductive amination of the in situ generated alcohol and amine via borrowing hydrogen is the dominant pathway.

Formula: C8H7NO. Welcome to talk about 59-48-3, If you have any questions, you can contact Pan, YX; Luo, ZL; Xu, X; Zhao, HQ; Han, JH; Xu, LJ; Fan, QH; Xiao, JL or send Email.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Quality Control of Indolin-2-one. I found the field of Chemistry very interesting. Saw the article Models for Understanding Divergent Reactivity in Lewis Acid-Catalyzed Transformations of Carbonyls and Olefins published in 2020.0, Reprint Addresses Reid, JP (corresponding author), Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA.; Schindler, CS (corresponding author), Univ Michigan, Willard Henry Dow Lab, Dept Chem, Ann Arbor, MI 48109 USA.. The CAS is 59-48-3. Through research, I have a further understanding and discovery of Indolin-2-one.

Carbonyl-ene, Prins, and carbonyl-olefin metathesis reactions represent powerful strategies for carbon-carbon bond formation relying on Lewis acid catalysts. Although common Lewis acids are able to provide efficient activation, the reactions often proceed with low regio- or chemoselectivity, while high selectivity frequently requires the use of well-designed metal-ligand complexes. Here we demonstrate that simple Lewis acids including Me2AlCl, FeCl3, and SnCl4 can show remarkable selectivity in differentiating between distinct transformations of carbonyl and olefin functional groups, resulting in either carbonyl-ene or carbonyl-olefin metathesis products. Specifically, we report the development of predictive multivariate linear regression models that rely on kinetic and thermodynamic information obtained in DFT calculations to gain important insights into the complex potential energy surfaces (PES) of these competing reaction paths. The presented results further our understanding of Lewis acid reactivity and suggest that even simple Lewis acids have the potential to function as highly selective catalysts.

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Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem