Category: 59-48-3

Authors Crotti, S; Di Iorio, N; Artusi, C; Mazzanti, A; Righi, P; Bencivenni, G in AMER CHEMICAL SOC published article about ASYMMETRIC-SYNTHESIS; ALPHA-BENZOYLOXYLATION; KINETIC RESOLUTION; CENTRAL CHIRALITY; BIARYLS; ISOMERIZATION; ATROPISOMERS; OLEFINATION; ALLENOATES; ALLENES in [Crotti, Simone; Di Iorio, Nicola; Artusi, Chiara; Mazzanti, Andrea; Righi, Paolo; Bencivenni, Giorgio] Univ Bologna, Dept Ind Chem Toso Montanari, Viale Risorgimento 4, I-40136 Bologna, Italy in 2019, Cited 65. Quality Control of Indolin-2-one. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3

The organocatalytic axially enantioselective Knoevenagel condensation between prochiral cyclohexanones and oxindoles is presented. The reaction, promoted by a primary amine, proceeded smoothly and furnished unprecedented examples of novel cyclohexylidene oxindoles displaying axial chirality.

Quality Control of Indolin-2-one. About Indolin-2-one, If you have any questions, you can contact Crotti, S; Di Iorio, N; Artusi, C; Mazzanti, A; Righi, P; Bencivenni, G or concate me.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

An article Harnessing Applied Potential: Selective beta-Hydrocarboxylation of Substituted Olefins WOS:000510531900023 published article about ELECTROINITIATED POLYMERIZATION; CARBON-DIOXIDE; VISIBLE-LIGHT; ELECTROCHEMICAL DICARBOXYLATION; STYRENE; CO2; ALKENES; ELECTROCARBOXYLATION; CARBOXYLATION; KINETICS in [Alkayal, Anas; Tabas, Volodymyr; Montanaro, Stephanie; Wright, Iain A.; Malkov, Andrei V.; Buckley, Benjamin R.] Loughborough Univ, Sch Sci, Dept Chem, Loughborough LE11 3TU, Leics, England in 2020, Cited 31. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3. COA of Formula: C8H7NO

The construction of carboxylic acid compounds in a selective fashion from low value materials such as alkenes remains a long-standing challenge to synthetic chemists. In particular, beta-addition to styrenes is underdeveloped. Herein we report a new electrosynthetic approach to the selective hydrocarboxylation of alkenes that overcomes the limitations of current transition metal and photochemical approaches. The reported method allows unprecedented direct access to carboxylic acids derived from beta,beta-trisubstituted alkenes, in a highly regioselective manner.

COA of Formula: C8H7NO. About Indolin-2-one, If you have any questions, you can contact Alkayal, A; Tabas, V; Montanaro, S; Wright, IA; Malkov, AV; Buckley, BR or concate me.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Computed Properties of C8H7NO. Authors Vaidya, GN; Nagpure, M; Kumar, D in AMER CHEMICAL SOC published article about in [Vaidya, Gargi Nikhil; Nagpure, Mithilesh; Kumar, Dinesh] Natl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Gandhinagar 382355, Gujarat, India in 2021, Cited 72. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3

A borrowing carbonate-enabled allylic cross-amination reactions employing allylic alcohol were discovered via merging acyl/allyl C-O bonds activation under nickel catalysis. The key component of this protocol is the ability of nickel [Ni(II)-Ni(0)] to execute a relay process via the nucleophilic trapping of the generated acyl Ni complex, resulting from the acyl C-O bond cleavage of dialkyl carbonates, followed by selective allylic C-O bond activations (allylic C-O vs alkyl C-O vs acyl C-O) to yield pi-allyINi-complexes. The finding truly represents Ni-catalyzed green allylic amination reactions under additive(s)-free conditions with excellent chemo- (N vs O), regio- (linear vs branched), and stereoselectivity (E vs Z) with a wide range of fundamentally challenging N-heterocycles and allylic alcohols. The reaction is scalable, does not require harmful reaction media and a globe box, and is successfully applied to the scale-up synthesis of pharmaceuticals (cinnarizine, flunarizine, and naftifine) with promising yields.

About Indolin-2-one, If you have any questions, you can contact Vaidya, GN; Nagpure, M; Kumar, D or concate me.. Computed Properties of C8H7NO

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

An article Triazatruxene-Based Ordered Porous Polymer: High Capacity CO2, CH4, and H-2 Capture, Heterogeneous Suzuki-Miyaura Catalytic Coupling, and Thermoelectric Properties WOS:000537656400101 published article about MICROPOROUS ORGANIC POLYMERS; GAS-STORAGE; HYPERCROSSLINKED POLYSTYRENE; LINKED POLYMERS; SURFACE-AREA; INTRINSIC MICROPOROSITY; NANOPOROUS POLYMER; HIGH-PERFORMANCE; BUILDING-BLOCKS; TROGERS BASE in [Sadak, Ali Enis; Karakus, Erman] TUBITAK UME, Chem Grp Labs, TR-41470 Kocaeli, Turkey; [Chumakov, Yurii M.] Gebze Tech Univ, Dept Phys, TR-41400 Kocaeli, Turkey; [Dogan, Nesibe A.; Yavuz, Cafer T.] Korea Adv Inst Sci & Technol KAIST, Dept Chem & Biomol Engn, Daejeon 34141, South Korea in 2020.0, Cited 74.0. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3. COA of Formula: C8H7NO

A hypercrosslinked ultramicroporous and ordered organic polymer network was synthesized from a planar trimer indole building block called triazatruxene (TAT) through anhydrous FeCl3 catalyzed Friedel-Crafts alkylation using methylal as a crosslinker. The polymer network is stable in a variety of chemicals and thermally durable. The hypercrosslinked network TATHCP shows a high BET (Brunauer-Emmet-Teller) specific surface area of 997 m(2) g(-1) with CO2 uptake capacity of 12.55 wt % at 273 K, 1.1 bar. Gas selectivities of 38.4 for CO2/N-2, 7.8 for CO2/CH4, 40.6 for CO2/O-2, and 32.1 for CO2/CO were achieved through IAST calculation. The PXRD analysis has revealed that TATHCP has a fully eclipsed structure in full agreement with Pawley refinement. The ordered 2D layers provide anisotropy that could be used in catalysis and thermoelectric measurements. After loading with Pd(II), TATHCP-Pd showed high catalytic activity in Suzuki-Miyaura cross coupling reaction with a wide range of reagents and excellent reaction yields of 90-98% with good recyclability. The structure of TATHCP-Pd was found to have two independent molecules of Pd(OAc)(2) in the asymmetric unit cell which are arranged between two TATHCP layers. Thermoelectric properties of TATHCP showed a high Seebeck coefficient and ZT, a first and promising example in HCPs with applications in all-organic thermal energy recovery devices.

COA of Formula: C8H7NO. About Indolin-2-one, If you have any questions, you can contact Sadak, AE; Karakus, E; Chumakov, YM; Dogan, NA; Yavuz, CT or concate me.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Recently I am researching about GENE-RELATED PEPTIDE; CLASS-B GPCR; ACTIVITY-MODIFYING PROTEIN-2; CRYO-EM STRUCTURE; STRUCTURAL INSIGHTS; COUPLED RECEPTORS; BINDING SITES; CGRP RECEPTOR; ADRENOMEDULLIN; RECOGNITION, Saw an article supported by the Health Research Council of New ZealandHealth Research Council of New Zealand; University of Auckland BioPharma Thematic Research Initiative; Lottery Health Commission of New Zealand; Auckland Medical Research Foundation Barbara Basham Doctoral Scholarship; Biotechnology and Biological Sciences Research CouncilUK Research & Innovation (UKRI)Biotechnology and Biological Sciences Research Council (BBSRC) [BB/M006883/1]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Hendrikse, ER; Liew, LP; Bower, RL; Bonnet, M; Jamaluddin, MA; Prodan, N; Richards, KD; Walker, CS; Pairaudeau, G; Smith, DM; Rujan, RM; Sudra, R; Reynolds, CA; Booe, JM; Pioszak, AA; Flanagan, JU; Hay, MP; Hay, DL. The CAS is 59-48-3. Through research, I have a further understanding and discovery of Indolin-2-one. Recommanded Product: Indolin-2-one

Class B G protein-coupled receptors are highly therapeutically relevant but challenges remain in identifying suitable small-molecule drugs. The calcitonin-like receptor (CLR) in particular is linked to conditions such as migraine, cardiovascular disease, and inflammatory bowel disease. The CLR cannot act as a cell-surface receptor alone but rather must couple to one of three receptor activity-modifying proteins (RAMPs), forming heterodimeric receptors for the peptides adrenomedullin and calcitonin gene-related peptide. These peptides have extended binding sites across their receptors. This is one reason why there are few small-molecule ligands that can modulate these receptors. Here we describe small molecules that are able to positively modulate the signaling of the CLR with all three RAMPs but are not active at the related calcitonin receptor. These compounds were selected from a beta-arrestin recruitment screen, coupled with rounds of medicinal chemistry to improve their activity. Translational potential is shown as the compounds can positively modulate cAMP signaling in a vascular cell line model. Binding experiments do not support an extracellular domain binding site; however, molecular modeling reveals potential allosteric binding sites in multiple receptor regions. These are the first small-molecule positive modulators described for the CLR:RAMP complexes.

Recommanded Product: Indolin-2-one. About Indolin-2-one, If you have any questions, you can contact Hendrikse, ER; Liew, LP; Bower, RL; Bonnet, M; Jamaluddin, MA; Prodan, N; Richards, KD; Walker, CS; Pairaudeau, G; Smith, DM; Rujan, RM; Sudra, R; Reynolds, CA; Booe, JM; Pioszak, AA; Flanagan, JU; Hay, MP; Hay, DL or concate me.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Product Details of 59-48-3. In 2020.0 PESTIC BIOCHEM PHYS published article about TOBACCO-MOSAIC-VIRUS; LULICONAZOLE; BIOACTIVITY; MECHANISMS; DESIGN in [Wei, Chunle; Zhao, Lei; Sun, Zhongrong; Hu, Deyu; Song, Baoan] Guizhou Univ, Minist Educ, Key Lab Green Pesticide & Agr Bioengn, State Key Lab Breeding Base Green Pesticide & Agr, Guiyang 550025, Peoples R China in 2020.0, Cited 33.0. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3.

Thirty unreported indole derivatives containing dithioacetal moiety were synthesized and evaluated for antiplant viral activity. Bioassay results displayed that some of the target compounds showed better activities against tobacco mosaic virus (TMV) than the commercial Ribavirin in vivo. In particular, anti-TMV curative, protective and inactivating activity of 4p were 55.1, 57.2, and 80.3%, respectively, and EC50 value for inactivating activity was 88.5 mu g/mL. The observation of transmission electron microscope showed that 4p may have a certain destructive effect on TMV particles. To further study, microscale thermophoresis analysis result also demonstrated that 4p powerfully interacted with TMV coat protein in vitro. Hence, this study provides a strong evidence suporting that indole derivatives might be applied as new antiviral agents.

Product Details of 59-48-3. About Indolin-2-one, If you have any questions, you can contact Wei, CL; Zhao, L; Sun, ZR; Hu, DY; Song, BA or concate me.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Computed Properties of C8H7NO. Authors Vaidya, GN; Nagpure, M; Kumar, D in AMER CHEMICAL SOC published article about in [Vaidya, Gargi Nikhil; Nagpure, Mithilesh; Kumar, Dinesh] Natl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Gandhinagar 382355, Gujarat, India in 2021, Cited 72. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3

A borrowing carbonate-enabled allylic cross-amination reactions employing allylic alcohol were discovered via merging acyl/allyl C-O bonds activation under nickel catalysis. The key component of this protocol is the ability of nickel [Ni(II)-Ni(0)] to execute a relay process via the nucleophilic trapping of the generated acyl Ni complex, resulting from the acyl C-O bond cleavage of dialkyl carbonates, followed by selective allylic C-O bond activations (allylic C-O vs alkyl C-O vs acyl C-O) to yield pi-allyINi-complexes. The finding truly represents Ni-catalyzed green allylic amination reactions under additive(s)-free conditions with excellent chemo- (N vs O), regio- (linear vs branched), and stereoselectivity (E vs Z) with a wide range of fundamentally challenging N-heterocycles and allylic alcohols. The reaction is scalable, does not require harmful reaction media and a globe box, and is successfully applied to the scale-up synthesis of pharmaceuticals (cinnarizine, flunarizine, and naftifine) with promising yields.

Computed Properties of C8H7NO. About Indolin-2-one, If you have any questions, you can contact Vaidya, GN; Nagpure, M; Kumar, D or concate me.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Authors Feng, JX; Huang, Y in AMER CHEMICAL SOC published article about GAMMA-SUBSTITUTED ALLENOATES; UMPOLUNG ADDITION-REACTION; CROSS-COUPLING REACTION; MORITA-BAYLIS-HILLMAN; DIASTEREOSELECTIVE SYNTHESIS; SEQUENTIAL ANNULATION; BOND FORMATION; 3+2 CYCLOADDITION; MICHAEL ADDITION; DOMINO REACTION in [Feng, Jiaxu; Huang, You] Nankai Univ, Coll Chem, State Key Lab, Tianjin 300071, Peoples R China; [Feng, Jiaxu; Huang, You] Nankai Univ, Coll Chem, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China in 2020.0, Cited 105.0. Category: indolines-derivatives. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3

A phosphine-catalyzed remote 1,7-addition of vinyl allenoates has been developed, providing a series of 1,3-dienes derivatives in high yields (up to 99%) and with good chemo-, regio-, and stereoselectivity. This reaction demonstrated that the introduction of vinyl in allenoates effectively extended reaction types of phosphine-catalyzed nucleophilic addition of allenoates, leading to concise synthesis of diene carboxylates. Notably, the enantioselective variant of this 1,7-addition can also be performed by chiral phosphine catalyst.

About Indolin-2-one, If you have any questions, you can contact Feng, JX; Huang, Y or concate me.. Category: indolines-derivatives

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

An article Visible-light-induced ligand-free RuCl3 catalyzed C-H phosphorylation in water WOS:000530725500014 published article about PHOTOREDOX CATALYSIS; MERGING PHOTOREDOX; ARYLATION; PHOSPHONATION; ALLYLAMINE; ROUTE; GREEN; ACIDS in [Gou, Xue-Ya; Zhang, Bo-Sheng; Wang, Xin-Gang; Shi, Wei-Yu; Liu, Hong-Chao; An, Yang; Zhang, Zhe; Liang, Yong-Min] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China in 2020.0, Cited 47.0. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3. HPLC of Formula: C8H7NO

Visible-light-induced C-H phosphorylation of para-C-Ar-H and heteroarenes was realized using cost-effective RuCl3 as a catalyst. The reaction conditions are green and environmentally friendly, using water as a solvent at room temperature and without ligands. A broad range of highly functional organophosphorus compounds were obtained via a cross-dehydrogenation-coupling (CDC) reaction. In addition, we also proved that RuCl3 is a photocatalyst via its absorption spectrum and on/off light experiments.

HPLC of Formula: C8H7NO. About Indolin-2-one, If you have any questions, you can contact Gou, XY; Zhang, BS; Wang, XG; Shi, WY; Liu, HC; An, Y; Zhang, Z; Liang, YM or concate me.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

An article Triazatruxene-Rhodamine-Based Ratiometric Fluorescent Chemosensor for the Sensitive, Rapid Detection of Trivalent Metal Ions: Aluminium (III), Iron (III) and Chromium (III) WOS:000519286200024 published article about SENSOR; FE3+; PROBE; CR3+; GLYCOCLUSTER; CATIONS; AL3+ in [Sadak, Ali Enis; Karakus, Erman] TUBITAK UME Sci & Technol Res Council Turkey, Organ Chem Lab, Natl Metrol Inst, Chem Grp, TR-41470 Kocaeli, Turkey in 2020.0, Cited 36.0. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3. Product Details of 59-48-3

We investigated the ability of a novel triazatruxene-rhodamine-based (TAT-ROD) chemosensor to detect the trivalent metal ions aluminium (Al3+), iron (Fe3+) and chromium (Cr3+). Operating via the through-bond energy transfer (TBET) pathway, the chemosensor exhibited low detection limits of 23.0, 25.0 and 170.0 nM for Al3+, Fe3+ and Cr3+, respectively, along with high sensitivity and selectivity during a brief period (<15 s). The binding ratio of the chemosensor and trivalent metal ions achieved by Job's method was 3:1, and when we added ethylenediaminetetraacetic acid (EDTA), the sensing process reversed. Altogether, our TAT-ROD chemosensor marks the first triazatruxene-based colorimetric and fluorometric metal ion sensor reported in the literature. Product Details of 59-48-3. About Indolin-2-one, If you have any questions, you can contact Sadak, AE; Karakus, E or concate me.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem