Category: 58083-59-3

Synthetic Route of 58083-59-3, The chemical industry reduces the impact on the environment during synthesis 58083-59-3, name is 6-Chloroisoindolin-1-one, I believe this compound will play a more active role in future production and life.

A mixture of 6-chloro-2, 3-dihydro-isoindol-1-one (0.115 g, 0.68 [MMOL)] and 6M hydrochloric acid (8 ml) in dioxan (1 ml) was heated to [110¡ãC] for 18 hours. After cooling to room temperature the solid was filtered off and dried in vacuo to give the title compound (0.0055g, 4 percent) as a beige solid. 1H-NMR (400 MHz, DMSO): [A] = 4.30 (brs, 2H), 7.58 (dd, 1H), 7.76 (dd, 1H), 8.22 (brs, 3H). LRMS [(ELECTROSPRAY)] : m/z [MH+] 186. Microanalysis : Found: C, 43.13 ; H, 4.05 ; N, 6. 18. [C8H8N02CI.] HCI requires C, 43.26 ; H, 4.08 ; N, 6. [31percent.]

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Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/14357; (2004); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Adding a certain compound to certain chemical reactions, such as: 58083-59-3, name is 6-Chloroisoindolin-1-one, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 58083-59-3, Safety of 6-Chloroisoindolin-1-one

A. A solution of 151 g of triethyloxonium tetrafluoroborate in 3200 ml of methylene chloride was stirred under argon at room temperature for 3.5 hours after the addition of 106.6 g of 6-chloro-2,3-dihydro-1H-isoindol-1-one. The mixture was then treated within 40 minutes with 1.28 l of saturated sodium hydrogen carbonate solution, the organic phase was separated and washed with 1.28 l of water. After drying over sodium sulphate the organic phase was filtered and evaporated. The residue was taken up in 1.3 l of diethyl ether, whereupon it was stirred at room temperature for about 30 minutes. After removing insoluble material by filtration the filtrate was evaporated. There was obtained 110.5 g of 1-ethoxy-6-chloro-3H-isoindole with a m.p. of 64¡ã-66¡ã.

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Reference:
Patent; Hoffmann-La Roche, Inc.; US5143912; (1992); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem