Category: 56341-37-8

In an article, author is Qin, Mingze, once mentioned the application of 56341-37-8, Application In Synthesis of 6-Chlorooxindole, Name is 6-Chlorooxindole, molecular formula is C8H6ClNO, molecular weight is 167.5923, MDL number is MFCD00209962, category is indolines-derivatives. Now introduce a scientific discovery about this category.

Discovery of the programmed cell death-1/programmed cell death-ligand 1 interaction inhibitors bearing an indoline scaffold

Inhibiting the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) pathway is an attractive strategy for tumor immunotherapy. Here, a novel series of indoline-containing compounds were developed, among which, A13 was identified as the most promising PD-1/PD-L1 pathway inhibitor. At the biochemical level, A13 demonstrated strong inhibition of the PD-1/PD-L1 interaction, with an IC50 of 132.8 nM. Notably, it exhibited outstanding immunoregulatory activity, and significantly elevated interferon-gamma secretion in a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, without significant toxic effect. Therefore, A13 could be employed as a suitable lead compound for further design of non-peptide inhibitors targeting the PD-1/PD-L1 interaction. In addition, the preliminary structure-activity relationships of these new indoline compounds were investigated in this study, providing valuable information for future drug development. (C) 2019 Elsevier Masson SAS. All rights reserved.

Interested yet? Read on for other articles about 56341-37-8, you can contact me at any time and look forward to more communication. Application In Synthesis of 6-Chlorooxindole.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 56341-37-8, Name is 6-Chlorooxindole, formurla is C8H6ClNO. In a document, author is Sheryn, Wong, introducing its new discovery. Category: indolines-derivatives.

In-vitro cytotoxicity of synthesized phthalide-fused indoles and indolines against HL-60 and HepG2 cells

Phthalide derivatives bearing indole or indoline moieties were successfully synthesized via eco-friendly method and were evaluated for their antiproliferative activity on HL-60 and HepG2 cell lines in vitro. At a final concentration of 100 mu M, most of the compounds showed moderate potency on both the cell lines tested. Compound 3b bearing 5-chloro substituted indoline had the best potency against HL-60 and HepG2 cell lines with IC50 values of 45.4 and 57.7 mu M, respectively. It was also found that replacement of a conjugated indoline to indole moiety gave better antiproliferative activity on HL-60 cells by almost two-fold. Morphological observation demonstrated numerous fragmented nuclei which are indicative of apoptosis. Molecular docking studies predicted non-covalent interactions and H-bonding of selected compounds with the P2 binding hot spot of the anti-apoptotic protein, Bcl-2, formed by Asp108, Phe109, Met112, Leu134, Arg143, Ala146 and Val153. Overall, our work highlights the potential of synthesized phthalide-fused indoles or indolines as antitumor agents. (C) 2019 Production and hosting by Elsevier B.V. on behalf of King Saud University.

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Reference of 56341-37-8, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 56341-37-8, Name is 6-Chlorooxindole, SMILES is O=C1NC2=C(C=CC(Cl)=C2)C1, belongs to indolines-derivatives compound. In a article, author is Hu, Kangfei, introduce new discover of the category.

Iodine-Mediated Electrochemical C(sp(2))-H Amination: Switchable Synthesis of Indolines and Indoles

A metal-free electrochemical intramolecular C(sp(2))-H amination using iodine as a mediator was developed. This method enables a switchable synthesis of indoline and indole derivatives, respectively, from easily available 2-vinyl anilines.

Reference of 56341-37-8, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 56341-37-8.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: 6-Chlorooxindole, 56341-37-8, Name is 6-Chlorooxindole, SMILES is O=C1NC2=C(C=CC(Cl)=C2)C1, belongs to indolines-derivatives compound. In a document, author is Ozhogin, Ilya V., introduce the new discover.

Synthesis and study of new photochromic unsymmetrical bisspiropyrans with nonequivalent heteroarene fragments conjugated through the common 2H,8H-pyrano[2,3-f]chromene moiety

Four novel bis-spiropyrans possessing two different photochromic units based on indoline and 1,3benzoxazine heterocycles which are connected through the common 2H,8H-pyrano[2,3-f]chromene moiety and modified with electron donating substituents were obtained by multistep synthesis starting with 2,4-dihydroxy-iso-phthalic aldehyde. The structure of the compounds was confirmed by H-1 and (CNMR)-C-13, FTIR and HRMS. All bis-spirocompounds exhibited photochromic activity at room temperature. Investigation of photochromic properties of bis-spiropyrans revealed that their once-opened merocyanine isomers were more stable than the double-opened ones under experimental conditions. It was also found that modification of the benzoxazine moiety of the molecule with electron donating substituents along with introduction of bulky benzyl group close to the oxazinespiro-center leads to an increase of the merocyanine lifetime up to 148 s. (C) 2020 Elsevier B.V. All rights reserved.y

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 56341-37-8. Recommanded Product: 6-Chlorooxindole.

In an article, author is Cheng, Xiangsheng, once mentioned the application of 56341-37-8, HPLC of Formula: C8H6ClNO, Name is 6-Chlorooxindole, molecular formula is C8H6ClNO, molecular weight is 167.5923, MDL number is MFCD00209962, category is indolines-derivatives. Now introduce a scientific discovery about this category.

DABCO-Catalyzed alpha-Regio- and Diastereoselective (3+2) Cycloadditions of Nitrone Ylides from Isatins and Activated Alkenes

alpha-Regio- and diastereoselective (3+2) cycloadditions of nitrone ylides derived from isatins with activated alkenes have been demonstrated. This mild protocol allows rapid access to a wide range of 3 ‘,5 ‘-diaryl-1 ‘-hydroxy-2-oxospiro[indoline-3,2 ‘-pyrrolidine] derivatives by using DABCO as an efficient catalyst. This method could also be carried out through three-component reaction efficiently in good yields and excellent diastereoselectivity.

If you are interested in 56341-37-8, you can contact me at any time and look forward to more communication. HPLC of Formula: C8H6ClNO.

Reference of 56341-37-8, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 56341-37-8, Name is 6-Chlorooxindole, SMILES is O=C1NC2=C(C=CC(Cl)=C2)C1, belongs to indolines-derivatives compound. In a article, author is Li, Ping, introduce new discover of the category.

Synthesis of N-Fused Seven-Membered Indoline-3-ones via a Palladium-Catalyzed One-Pot Insertion Reaction from 2-Alkynyl Arylazides and Cyclic beta-Diketones

A novel strategy to synthesize N-fused seven-membered multifunctional polycyclic indoline-3-one derivatives via insertion of cyclic C-acylimines into cyclic beta-diketones has been described. The reaction proceeded well under mild reaction conditions via a one-pot, three-steps method, which has shown good tolerance of various functional groups.

Reference of 56341-37-8, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 56341-37-8 is helpful to your research.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 56341-37-8, Name is 6-Chlorooxindole, SMILES is O=C1NC2=C(C=CC(Cl)=C2)C1, belongs to indolines-derivatives compound. In a document, author is Sun, Bin-Bin, introduce the new discover, Formula: C8H6ClNO.

Preparation and analysis of photochromic behavior of carboxymethyl chitin derivatives containing spiropyran moieties

1MODIFIER LETTER PRIME-(2-Acryloxyethyl)-3,3MODIFIER LETTER PRIME-dimethyl-6-nitrospiro[2 H-1-benzopyran-2,2MODIFIER LETTER PRIME-indoline] (SPA) was synthesized and grafted onto a water-soluble carboxymethyl chitin (CMCH) macromolecule to prepare a photochromic copolymer (CMCH-g-SPA). The structure of CMCH-g-SPA was characterized by Fourier-transform infrared (FT-IR) spectroscopy, thermogravimetric (TG) analysis, X-ray diffraction (XRD) analysis, water-solubility evaluation, and UV-vis spectroscopy. XRD patterns of CMCH-g-SPA revealed that grafting copolymerization disrupts the CMCH semicrystalline structure, thus improving water solubility. UV-vis spectroscopy results supported the negative photochromic behavior of the merocyanine (MC) form of CMCH-g-SPA (CMCH-g-MCA) present in a water solution of the target copolymer. In addition to high solvent polarity, the intermolecular and intramolecular electrostatic attraction between the indolenine cation and the COO(-)anion were found to be influencing factors, which stabilize these MC form of spiropyran groups grafted onto CMCH. In a water solution, visible light bleaching was completed over a short period (8 minutes) under artificial visible light irradiation and the thermal coloration reaction, whose rate constant at 25 degrees C was 4.64 x 10(-4) s(-1), which fit the first-order reaction equation. After ten photochromic cycles in water solution, the relative absorption intensity of CMCH-g-MCA decreased by 7.92%.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 56341-37-8 is helpful to your research. Formula: C8H6ClNO.

56341-37-8, Name is 6-Chlorooxindole, molecular formula is C8H6ClNO, belongs to indolines-derivatives compound, is a common compound. In a patnet, author is Ahmadi, Sina, once mentioned the new application about 56341-37-8, HPLC of Formula: C8H6ClNO.

Synthesis and characterization of apHand photoresponsive copolymer of acrylamide and spiropyran

In this research, the solution properties of acrylamide and spiropyran acrylate copolymers were investigated. Spiropyran acrylate was synthesized by the reaction of 1 ‘,3 ‘,3 ‘-trimethyl-6-hydroxyspiro(2H-1-benzopyran-2,2 ‘-indoline) and acryloyl chloride. The free radical solution polymerization was used to attain a specialty responsive polymer. Characterization was carried out using nuclear magnetic resonance (NMR), Fourier-transform spectroscopy (FTIR), and ultraviolet-visible spectroscopy (UV-vis). The FTIR and NMR results showed that the copolymer synthesis was successful, and the copolymer contained spiropyran monomer. UV analyses indicated that the photoresponsive behavior of the copolymer in the protic and aprotic solvents was quite the opposite, and the polymer absorption spectrum in the basic aqueous solutions was red-shifted.

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56341-37-8, Name is 6-Chlorooxindole, molecular formula is C8H6ClNO, belongs to indolines-derivatives compound, is a common compound. In a patnet, author is Ghasemi, Mehran, once mentioned the new application about 56341-37-8, Quality Control of 6-Chlorooxindole.

Palladium/Norbornene Chemistry in the Synthesis of Polycyclic Indolines with Simple Nitrogen Sources

An efficient procedure has been developed to synthesize -indoline derivatives through a palladium-catalyzed Heck reaction/C-H activation/dual amination cascade in one pot. This constitutes the first intermolecular catalytic approach to directly accessN-alkylindolines with a broad substrate scope in the absence of any ligands. This method highlights the use of readily available amines and ureas as the required nitrogen sources in building up the indoline core.

If you¡¯re interested in learning more about 56341-37-8. The above is the message from the blog manager. Quality Control of 6-Chlorooxindole.

Chemistry is an experimental science, Name: 6-Chlorooxindole, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 56341-37-8, Name is 6-Chlorooxindole, molecular formula is C8H6ClNO, belongs to indolines-derivatives compound. In a document, author is Abdoli, Mahshid.

One-pot synthesis of spiro-acridine/indoline and indoline derivatives using (MWCNTs)-COOH/La2O3 hybrid as an effective catalyst

Spiro-acridine/indoline and indoline derivatives were synthesized by the three-component reaction of isatin, dimedone, and amines or amino acids in the presence of acid-functionalized multiwalled carbon nanotubes/La2O3 (MWCNTs)-COOH/La2O3 hybrid (5 mol%) as a highly efficient catalyst in ethanol. The assigned structure was further established by CHN analysis, NMR, and FTIR spectra. (MWCNTs)-COOH/La2O3 was fabricated by the reaction of functionalized (MWCNTs)-COOH and La(NO3)(3).6H(2)O in acetic acid. Synthesis of La2O3 nanoparticles and their conjugation on the surface of MWCNT have been confirmed by FTIR, scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and energy-dispersive X-ray spectroscopy.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 56341-37-8, in my other articles. Name: 6-Chlorooxindole.