Category: 550-44-7

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 550-44-7 as follows. HPLC of Formula: C9H7NO2

(3,3? ? ,5,5? ? -tetra(trifluoromethyl)-1,1? :3?,1? ? -terphen-5? -yl)magnesium iodide was prepared from 5? -iodo-3,3? ? ,5,5? ? -tetra(trifluoromethyl)-1,1? :3? ,1? ? -terphenyl (3.49 g, 6.0 mmol) and magnesiumturnings (1.0 g) activated by 1,2-dibromoethane in diethyl ether (20 ml) at roomtemperature. The suspension of the Grignard reagent was cannulated into a solution of N-methylphthalimide (161 mg, 1.0 mmol) in toluene (10 ml) at roomtemperature. The mixture was heated in an oil bath at 120 C and concentrateduntil the volume was reduced to around 10 ml. Then, the Schlenk flask wassealed and stirred at 120 C for 1 d. After cooling to room temperature, themixture was quenched by a saturated aqueous NH4Cl solution and extracted withdichloromethane (3 ¡Á 50 ml). The combined organic phase was dried over MgSO4,filtered through a pad of Celite and evaporated to dryness, and the residue waspurified by flash silica-gel column chromatography (hexane/EtOAc = 97/3 to90/10). All fractions containing 1c were combined and evaporated to dryness.The obtained crude 1c was washed with hexane and benzene repeatedly, thendried in vacuo at 120 C overnight to afford 1c as a colourless solid (783 mg,0.37 mmol, 37% yield). 1H, 13C{1H} and 19F{1H} NMR spectra can be found inSupplementary Figs. 5-7.

According to the analysis of related databases, 550-44-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Nakano, Ryo; Jazzar, Rodolphe; Bertrand, Guy; Nature Chemistry; vol. 10; 12; (2018); p. 1196 – 1200;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

These common heterocyclic compound, 550-44-7, name is 2-Methylisoindoline-1,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Methylisoindoline-1,3-dione

General procedure: To N-methylphthalimide (1a) (8 mmol), N-benzylphthalimide (1e) (8 mmol) or appropriate compound 2b-d(8 mmol) stirred in acetic acid (25 mL) tin granular (1.90 g, 16 mmol) and hydrochloric acid (10 mL, d25 = 1.2 g/mL) were added. The whole lotwas heated to reflux for 3 h. The solvents were removed under reduced pressure and to the residue were added ethyl acetate (50 mL) and sodium carbonate solution(10% in water) to obtain an alkaline environment. Then the organic layer was separated, washed with water, dried with magnesium sulfate(VI) and evaporated to give the crude products 3. Thecompounds 3 were purified by crystallization.

The synthetic route of 2-Methylisoindoline-1,3-dione has been constantly updated, and we look forward to future research findings.

Reference:
Article; Jo?wiak, Andrzej; Zagorski, Piotr M.; P?otka, Mieczys?aw W.; Cal, Dariusz; Tetrahedron Letters; vol. 55; 15; (2014); p. 2420 – 2422;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Application of 550-44-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 550-44-7, name is 2-Methylisoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

1) Production of 1,1,2,3,3-pentamethylisoindoline: With cooling with ice, 1.40 g of zirconium chloride was added to 6.0 mL of a THF solution of 483 mg of N-methylphthalimide, and stirred for 30 minutes with cooling with ice. 18.7 mL of 0.96 M methylmagnesium chloride/THF solution was added to it, and stirred at room temperature for 18 hours. With cooling with ice, 20 mL of aqueous 5 M sodium hydroxide solution was added to the reaction liquid, and extracted with chloroform. The organic layer was dried with anhydrous sodium sulfate, and the solvent was evaporated away under reduced pressure. The crude product was purified through NH silica gel column chromatography (hexane/ethyl acetate) to obtain 105 mg of the entitled compound as a yellow solid. 1H-NMR (400 MHz, CDCl3) delta: 7.25-7.20 (2H, m), 7.17-7.13 (2H, m), 2.42 (3H, s), 1.33 (12H, s) ESI-MS Found: m/z [M+H]+ 190

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methylisoindoline-1,3-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Banyu Pharmaceutical Co., Ltd.; EP2168966; (2010); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem