Category: 5332-26-3

Related Products of 5332-26-3, The chemical industry reduces the impact on the environment during synthesis 5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione, I believe this compound will play a more active role in future production and life.

General procedure: The vacuum dried intermediate 3 (0.002 mol) was then reacted with mono- and di-substituted benzoic acids (0.003 mol) separately in presence of anhydrous potassium carbonate (0.003 mol) in DMF (10 mL). The reaction mixture was stirred at room temperature for about 2 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was poured into ice-cold water and allowed stir for 10 min. The solid obtained was filtered and washed successively with distilled water and recrystallized from ethanol to obtain4(a-n).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(Bromomethyl)isoindoline-1,3-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kumar, C.S. Chidan; Loh, Wan-Sin; Chandraju, Siddegowda; Win, Yip-Foo; Tan, Weng Kang; Quah, Ching Kheng; Fun, Hoong-Kun; PLoS ONE; vol. 10; 3; (2015);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 5332-26-3

By preheating the internal reactor is sufficiently dried, after substituting dry nitrogen, into the reactor, 4-[ (2-methacryloyloxy) halogenoethoxy]-4-aminobutyric oxopiperidine 11. 51g (0. 05mol), triethylamineborane 6. 07g (0. 06mol), dimethyl formamide (DMF) 150 ml is added. By heating the oil bath 65 C, while stirring, N-(bromomethylbiphenyl) tetrafluorophthalimide 12. 00g (0. 05mol) dissolved in 15 minutes to DMF100mL is added. After the first period, by distilling evaporator DMF, residue extracted with ethyl acetate is obtained. The extract is washed with water to 3 times, then the saturated aqueous solution of sodium bicarbonate, saturated saline successively washed, dried with sodium sulfate (desiccant). Furthermore, after the drying agent is then filtered by a Buchner funnel, distilling organic solvent. In this way, the eq. (M-20) shown (1, 3-dioxo isoindolin-2-yl) methyl 2-(methacryloyloxy) ethyl succinate (13. 95g (yield 72%))is obtained.

The synthetic route of 5332-26-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JSR CORPORATION; ASANO, YUSUKE; SATO, MITSUO; (60 pag.)JP2015/38072; (2015); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Recommanded Product: 2-(Bromomethyl)isoindoline-1,3-dione

General procedure: A mixture of 1.02 g (7.4 mmol) of freshly calcined K2CO3, 7.0 mmol of the corresponding 2-thiouracil 1-3 and 7.7 mmol of 2-(bromomethyl)-2Hisoindole-1,3-dione in 20 mL of anhydrous DMF was stirred at room temperature for 72 h. The mixture was filtered, the fi ltrate was evaporated to dryness under reduced pressure. The precipitate of mineral salts on the filter was dissolved in 1 M. aqueous H3PO4 and the resulting solution was combined with the bottom residue. The resulting mixture was filtered. The filtercake was washed with water, and then the filtrate was extracted EtOAc (3×50 mL). The filter cake was air dried to constant weight, and the organic extract was dried over anhydrous MgSO4. The dried organic extract was evaporated to dryness under reduced pressure. The residue was mixed with the filter cake and evaporated in a mixture with toluene (3×50 mL) under reduced pressure. A crude product was obtained in the residue, which was subjected to further purification using preparative HPLC.

The synthetic route of 5332-26-3 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., SDS of cas: 5332-26-3

The pure compound 5 (40 g, 94 mmol) was dissolved in anhydrous tetrahydrofuran (400 ml).Nitrogen replacement,Dry ice acetone cooled to -78 degrees,Slowly add tetrahydrofuran solution of sodium hexamethyldisilazide(112.8 mmol, the concentration of sodium hexamethyldisilazide is 2 mol/L),After completion of the dropwise addition, the system was stirred at -78C for 1 hour;Compound 13 (108 mmol) was dissolved in 400 ml anhydrous tetrahydrofuran (THF).The above system was slowly dropped through a constant pressure funnel.Control the dropping temperature below -70 degrees,After the addition was completed, the reaction was kept stirring at -78 degrees for 3 hours.It is naturally warmed to room temperature and stirred overnight.TLC showed that the starting material was completely reacted. The reaction was quenched with 500 ml of saturated aqueous ammonium chloride solution. The solvent tetrahydrofuran was removed by rotary evaporation. The residue was extracted three times with ethyl acetate (200 ml each time) and the combined organic phases were washed with saturated brine. Sodium sulphate was dried, filtered and spin-dried to obtain crude compound 6 and purified by column to obtain pure compound 6 (43 g) in a yield (78.24%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5332-26-3, Product Details of 5332-26-3

To a stirred solution of 26 (50.0 g, 0.142 mol) in THF (500 mL) was added NaHMDS (2 M in THF, 106.2 mL, 0.213 mol) at 0 C and the resultant mixture was stirred for about 30 min. Then 2-(bromomethyl)isoindoline-1,3-dione (17; 41.0 g, 0.171 mol) was added at 0 C and the resultant reaction mixture was stirred for about 30 min. The reaction mixture was quenched with H2O (500 mL) at 0 C and extracted with EtOAc (2 × 500 mL). The combined organic layers were washed with H2O and brine, and concentrated to get the crude compound of 27, which was purified by column chromatography using PE/EtOAc (8.5:1.5) as eluent to afford the desired compound 27 as a colorless syrup; yield: 51 g (70%). 1H NMR (400 MHz, CDCl3): delta= 7.87-7.84 (m, 2 H), 7.78-7.75 (m, 2 H),7.42-7.33 (m, 5 H), 5.80 (br s, 1 H), 5.25-5.18 (m, 2 H), 4.32 (s, 2 H),4.18 (q, J= 7.2 Hz, 2 H), 3.74-3.61 (m, 2 H), 1.45 (s, 9 H), 1.19 (t, J= 6.8Hz, 3 H). 13C NMR (100 MHz, CDCl3): delta= 168.6, 168.5, 168.4, 155.5, 135.4,134.4, 131.6, 128.4, 128.3, 128.2, 123.7, 123.6, 79.3, 67.6, 62.1, 57.6,40.9, 38.7, 28.3, 13.7.LCMS: m/z= 511 [M + 1]. HRMS: m/z[M]+calcd for C27H31N2O8+: 511.2075; found: 511.2068.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference of 5332-26-3, A common heterocyclic compound, 5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione, molecular formula is C9H6BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Benzimidazole (1 mmol) and potassium hydroxide (1 mmol) were dissolved in ethyl alcohol (60 mL). The alkyl halide (1 mmol) was slowly added after the obtained reaction mixture was stirred at room temperature for 1 h. The solution was refluxed for 6 h, cooled to roomtemperature and the precipitated potassium chloride was removed by filtration. The solvent was removed by distillation. The product was then crystallized, washed several times with diethyl ether and then dried in vacuo. To a solution of 1-alkylbenzimidazole (1 mmol) in dried DMF (4 mL), alkyl halide (1 mmol) was added slowly and the reaction mixture was stirred at 80 C for 24 h under argon. After completion of the reaction, the DMF was removed by vacuum and diethyl ether (15 mL) was added to the mixture. The solid was washed with diethyl ether (2 × 15 mL) and dried under vacuum. The product was crystallized in an ethanol/diethyl ether mixture (3:1) at room temperature. The purified compounds were obtained as white or cream solids. Their structures were characterized by NMR (1H and 13C), FTIR, ESI-FTICR-MS (for 2 and 4) spectroscopic methods and elemental analysis

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 5332-26-3,Some common heterocyclic compound, 5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione, molecular formula is C9H6BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The starting carborane, 1-C6H5-1,2-C2B10H11 1.00 g (4.53 mmol) dried in vacuum, was dissolved in DME (40 ml) in Schlenk-type flask under argon, and the resulting solution was cooled down to -33 C. and BuLi (2.5 M in hexane, Aldrich, 2.0 ml, 5.0 mmol) was added under stirring from a syringe through septum. The reaction slurry was stirred for 15 min. and then left to warm up to room temperature. The reaction mixture was again cooled down and bromomethyl phtalimide 1.20 g (Aldrich, 5.0 mmol) dissolved in v 15 ml of DME was added dropwise from a syringe. The reaction mixture was stirred for 15 min. -33 C. at and then left slowly to warm up to room temperature over 4 h period. After standing overnight, the solids were filtered off under argon, and washed under argon with two portions of DME (10 ml). Diluted acetic acid (3 M, 0.5 ml) was added to the combined DME extracts and volatiles were removed under reduced pressure. A solid residue was dissolved in benzene and poured atop of a silica gel column (3*25 cm). Elution with benzene led to isolation of the starting 1-Ph-carborane (240 mg), continued elution using benzene-CH3CN (4:1, b.v.) solvent mixture afforded the methylene-phtalimide substituted intermediate carborane 0.85 g (49%).

The synthetic route of 5332-26-3 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5332-26-3, COA of Formula: C9H6BrNO2

EXAMPLE 20 Reaction of N-bromomethylphthalimide with trimethyl phosphite as described in Example 18 for N-(2-bromoethyl)phthalimide and triethyl phosphite gives dimethyl phthalimidomethylphosphonate.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(Bromomethyl)isoindoline-1,3-dione, other downstream synthetic routes, hurry up and to see.

Application of 5332-26-3,Some common heterocyclic compound, 5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione, molecular formula is C9H6BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The vacuum dried intermediate 3 (0.002 mol) was then reacted with mono- and di-substituted benzoic acids (0.003 mol) separately in presence of anhydrous potassium carbonate (0.003 mol) in DMF (10 mL). The reaction mixture was stirred at room temperature for about 2 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was poured into ice-cold water and allowed stir for 10 min. The solid obtained was filtered and washed successively with distilled water and recrystallized from ethanol to obtain4(a-n).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(Bromomethyl)isoindoline-1,3-dione, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., name: 2-(Bromomethyl)isoindoline-1,3-dione

0.021 mol (4.99 g) of 2-(bromomethyl)-1H-isoindole-1,3(2H)-dione ( Sigma-Aldrich) was added to a solution of 4.04 g (0.020 mol) of the compound XA0 obtained in substage 1.1) of Example 1 in 35 ml of acetone (Sigma-Aldrich), in an ice bath (highly exothermic reaction). Once the addition was complete, the reaction medium was stirred at ambient temperature for 3 hours and then filtered. The filtrate was concentrated under vacuum in order to obtain the expected product XA2 in the form of a yellow oil (5.84 g, yield 91%) which will be used in the following stage without purification.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE TOULOUSE III – Paul Sabatier; COUTELIER, Olivier; DESTARAC, Mathias; LANGLAIS, Marvin; (16 pag.)US2019/359603; (2019); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem