Category: 52351-75-4

A common heterocyclic compound, 52351-75-4, name is 6-Methoxyindoline-2,3-dione, molecular formula is C9H7NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 52351-75-4.

A mixture of 6-methoxyisatin (0.18g, 0.001mol) in Anhyd. ethanol (2ml) and thiosemicarbazide(0.1g, 0.0011 mol) in a mixture of water (2 ml) andglacial acetic acid (0.5 ml) was irradiated undermicrowave irradiation at 560W for 5-minutes. Ayellow coloured solid formed during irradiation. Thesolid was filtered, washed well with water andcrystallized from ethanol-DMF furnishing yellowcrystals. Yield 0.247g (95%), m.p. 265OC.[Found :N, 22.68, S, 12.62. C10H10N4O2S requires N, 22.40;S, 12.80%]; IR: 825, 860 (1, 2, 4-trisubstitutedbenzene ring), 1115 (C=S), 1125 & 1370 (C-O-Cstretching), 1620 (C=N), 1700 (C=O), 3200, 3280,3400 (NH, NH2).

The synthetic route of 6-Methoxyindoline-2,3-dione has been constantly updated, and we look forward to future research findings.

Reference:
Article; Singh, Ravinder; Oriental Journal of Chemistry; vol. 31; 1; (2015); p. 509 – 513;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

52351-75-4, Adding a certain compound to certain chemical reactions, such as: 52351-75-4, name is 6-Methoxyindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52351-75-4.

6-Methoxylisatin (6 g, 33.87 mmol), 1 -indan-ethanone (40.64 mmol), and o 85% KOH pellets (120 mmol) were dissolved in EtOH (40 mL). The reaction mixture was stirred at 800C for 24 hours. After the solvent was removed by evaporation, the residue thus obtained was dissolved in H2O (50 mL). The solution was then washed twice with Et2O (30 mL). The aqueous phase was cooled by an ice- water bath and acidified with a 37% HCl aqueous solution to pH 1. The precipitate was collected by suction filtration, washed with H2O, and dried to give compound I- 20, 2-indan-5-yl-7-methoxy-quinoline-4-carboxylic acid (9.5 g, 88%) as a solid. ESI- MS (M+H+) = 320.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Methoxyindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TAIGEN BIOTECHNOLOGY CO. LTD.; WO2008/95058; (2008); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem