In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4770-32-5 as follows. Formula: C10H11NO2
To a solution of the title compound from step 3 (3.0 g, 16.95 mmol) in AcOH (25 mL) was added a solution of NBS (3.01 g, 16.95 mmol) in AcOH (25 mL) slowly at 10C-20C. The mixture was stirred at that temperature for 1 hr. It was then poured over water (50 ml) and extracted with CH2CI2 (200 ml x 5). The combined organic phases were washed with brine, dried over Na2S04, filtered and concentrated. The residue was purified by column chromatography (PE: EA=10: 1-1: 1) to provide the title compound (1.10 g, 25% yield) as a solid. H NMR (DMSO-d6, 400 MHz) delta 9.90 (s, 1 H), 8.14 (s, 1 H), 6.83 (s, 1 H), 4.05 (t, J=8.4 Hz, 2 H), 3.04 (t, J = 8.4 Hz, 2 H), 2.11 (s, 3 H). LCMS: 256.0, 258.0 [M+H]+.
According to the analysis of related databases, 4770-32-5, the application of this compound in the production field has become more and more popular.