Category: 4702-13-0

Synthetic Route of 4702-13-0, These common heterocyclic compound, 4702-13-0, name is N-Phthaloylglycine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of N-Phthaloylglycine (10.0 g, 48.7 mmol) in DCM (100 mL) was added oxalyl chloride (6.3 mL, 73.1 mmol) at r.t., followed by a drop of DMF. The reaction was stirred for 2 h and then concentrated to give compound 651 (10.8 g) as a yellow solid.

Statistics shows that N-Phthaloylglycine is playing an increasingly important role. we look forward to future research findings about 4702-13-0.

Reference:
Patent; HANGZHOU DAC BIOTECH CO. LTD; ZHAO, Robert Yongxin; YANG, Qingliang; HUANG, Yuanyuan; ZHAO, Linyao; GAI, Shun; YE, Hangbo; LEI, Jun; XU, Yifang; CAO, Mingjun; GUO, Huihui; JIA, Junxiang; TONG, Qianqian; LI, Wenjun; ZHOU, Xiaomai; XIE, Hongsheng; BAI, Lu; CAI, Xiang; ZHUO, Xiaotao; ZHANG, Xiuzheng; ZHENG, Jun; (424 pag.)WO2019/127607; (2019); A1;,
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Related Products of 4702-13-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4702-13-0, name is N-Phthaloylglycine belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Reference Example 4 Phthalimidoacetyl chloride A mixture of phthalimidoacetic acid (25.1 g, 0.122 mol) and thionyl chloride (50 mL) was heated for one hour under reflux. The reaction mixture was cooled and, then, concentrated under reduced pressure. The concentrate was recrystallized from dichloromethane-hexane to give 26.4 g (97%) the titled compound, which was used for the subsequent reaction without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Phthaloylglycine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US5834463; (1998); A;,
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Adding a certain compound to certain chemical reactions, such as: 4702-13-0, name is N-Phthaloylglycine, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4702-13-0, Product Details of 4702-13-0

Typical Procedure: To a 30-mL vial was added N-phthaloylglycine (2.05 g, 10 mmol) and SOCl2 (8 mL) and the vial was sealed. The reaction was stirred in an oil bath at 60 C for 8 h. The mixture was cooled to r.t., the SOCl2 was removed in vacuo, hexane (10 mL) was added, and the mixture was stirred for 10 min resulting in white solid. After filtration, the solid (2.0 g, 90%) was washed with hexane and used directly in the next reaction. Phthaloylglycyl chloride (2.0 g, 9.0 mmol) in CH2Cl2 (8 mL) was added dropwise to the solution of 11a (2.2 g, 7.9 mmol) and Et3N (3.0 mL) in CH2Cl2 (50 mL). The mixture was stirred at r.t. until completion of the reaction, then diluted with CH2Cl2 (150 mL). The organic phase was washed with H2O (3 ¡Á 40mL) and brine, dried (anhyd Na2SO4), and concentrated in vacuo. The residue was purified by flash column chromatography (silicagel) to afford 10a (3.2 g, 89%) as a yellowish solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Huang, Liye; Yu, Ruina; Leng, Ling; Gong, Feng; Zhu, Xinhai; Wan, Yiqian; Synthesis; vol. 46; 17; (2014); p. 2317 – 2326;,
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Synthetic Route of 4702-13-0,Some common heterocyclic compound, 4702-13-0, name is N-Phthaloylglycine, molecular formula is C10H7NO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of amino-acid phthalyl derivative(0.001 mol) and thionylchloride (6 mL) was refluxed for 3 h at 50C. The excess of thionylchloride was vacuum distilled.Anhydrous toluene was added to the reaction flask and distilled off in vacuo three times for complete removal of thionylchloride.Then, obtained chlorides 2 and 3 were used for acylation.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N-Phthaloylglycine, its application will become more common.

Reference:
Article; Gabbasov; Tsyrlina; Spirikhin; Yunusov; Chemistry of Natural Compounds; vol. 54; 5; (2018); p. 951 – 955; Khim. Prir. Soedin.; 5; (2018); p. 806 – 809,4;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4702-13-0, name is N-Phthaloylglycine, A new synthetic method of this compound is introduced below., COA of Formula: C10H7NO4

(a) Preparation of 1,3-dihydro-1,3-dioxo-2H-isoindole-2-acetyl chloride STR10 A solution of 1,3-dihydro-1,3-dioxo-2H-isoindole-2-acetic acid (7.00 g) and thionyl chloride (12 mL) was stirred at reflux under nitrogen for one hour. The thionyl chloride was distilled from the reaction, and the resulting crude product was further purified by distillation via a kugelrohr apparatus (BUCHI, Flawil, Switzerland). [Bp: 160-180 C. (oven temperature) at 10 mm Hg.]The yield of the title compound was 6.88 grams (90.2%). The structure of the title compound, and of all of the compounds synthesised in each of the subsequent examples, was confirmed by 1 H NMR.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; G. D. Searle & Co.; US5212169; (1993); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4702-13-0, name is N-Phthaloylglycine belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. 4702-13-0

To a solution of phthaloylglycin (0.300 g, 1.46 mmol) in CH2Cl2 was added oxalyl chloride (1.480 g, 11.66 mmol) and DMF (0.010 g, 0.137 mmol) at 0 C. The mixture was stirred at 0 C for 30 min., then warmed to room temperature and stirred for 3 h. The solvent was removed under reduced pressure. The solid residue was dissolved in CH2Cl2 and evaporated under reduced pressure (this procedure was repeated three times). The crude product was dried under vacuum to afford a yellow sold (0.310 g, 95%). This compound was used for next reaction without further purification.1H NMR (500 MHz, CDCl3). delta 7.91 (dd, J = 5.5, 3.2 Hz, 2H), 7.79 (dd, J = 5.5, 3.1 Hz, 2H), 4.82 (s, 2H).

The synthetic route of 4702-13-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC.; BURNETTE, Pearlie; LAWRENCE, Harshani; LAWRENCE, Nicholas J.; (285 pag.)WO2017/161119; (2017); A1;,
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A common heterocyclic compound, 4702-13-0, name is N-Phthaloylglycine, molecular formula is C10H7NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 4702-13-0.

Commercially available N-phthaloylglycine (32, 200mg, 0.975mmol) was dissolved in SOCl2 (2.84mL) and refluxed for 2h. After evaporation of the solvent under reduced pressure, the obtained white solid was solubilized in THF (1.7mL), and treated with tris(trimethylsilyl)phosphite (978muL, 2.92mmol) at 0C for 15min, and then stirred at room temperature for 15min. Methanol (4mL) was added and the solution was stirred for 1hat room temperature. The solvent was evaporated under vacuum and the white solid was washed three times with a toluene/hexane mixture (1:1) (4mL), washed with Et2O and dried under vacuum, obtaining the intermediate 37. Yield: 337mg (98.5%).

The synthetic route of N-Phthaloylglycine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Savino, Salvatore; Toscano, Annamaria; Purgatorio, Rosa; Profilo, Emanuela; Laghezza, Antonio; Tortorella, Paolo; Angelelli, Mariacristina; Cellamarea, Saverio; Scala, Rosa; Tricarico, Domenico; Thomas Marobbio, Carlo Marya; Perna, Filippo; Vitale, Paola; Agamennone, Mariangela; Dimiccoli, Vincenzo; Tolomeo, Anna; Scilimati, Antonio; European Journal of Medicinal Chemistry; vol. 158; (2018); p. 184 – 200;,
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