Category: 446292-07-5

The chemical industry reduces the impact on the environment during synthesis 446292-07-5, name is (R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione, I believe this compound will play a more active role in future production and life. 446292-07-5

Add 28 kg of rivaroxaban intermediate IV to 280 L of absolute ethanol, and add 36.5 kg of 40% methylamine solution.After refluxing for 1 h, the temperature was lowered to 50-60 C.Add 6N hydrochloric acid to adjust the pH to 2~3,Cool down to room temperature, centrifuge,Drying the filter cake to obtain rivaroxaban intermediate V(4-[4-[(5S)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone hydrochloride) 19.66kg,The yield is 90.3%,The purity is 99.78%.

The chemical industry reduces the impact on the environment during synthesis 446292-07-5. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Qilu Pharmaceutical Co., Ltd.; Fan Chuanwen; Leng Chuanxin; Wang Yubing; Liu Peiyuan; (6 pag.)CN109553611; (2019); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

446292-07-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 446292-07-5, name is (R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione, This compound has unique chemical properties. The synthetic route is as follows.

A compound having the structure of formula (I) (106.76 g, 270 mmol) was suspended in 4000 ml of anhydrous tetrahydrofuran(About 40ml / g), stir, gradually heated to 50 C, maintained at 50 C,A solution of triphosgene (80.2 g, 270 mmol) in tetrahydrofuran (268 ml) was added dropwise over 30 minutes,Heated to 64 C reflux, about 10 minutes after the clarification, about 1 hour and precipitation of solid, let cool to room temperature,The filter cake was washed with absolute ethanol (120 ml * 3 times) and air dried at 45 C to give 111.4 g of a compound having the structure of formula (II) in a yield of 97.9%

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Reference:
Patent; SHENZHEN HYBIO PHARMACEUTICAL CO., LTD.; YUAN, HUIXING; XIAO, QING; LI, GUOTAO; MA, YAPING; YUAN, JIANCHENG; (21 pag.)CN104016975; (2017); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem