Category: 4403-36-5

Continuously updated synthesis method about 4403-36-5

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(1,3-Dioxoisoindolin-2-yl)ethanesulfonylchloride, and friends who are interested can also refer to it.

Related Products of 4403-36-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4403-36-5 name is 2-(1,3-Dioxoisoindolin-2-yl)ethanesulfonylchloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Triethylamine (50 muL), DMAP (catalytic amount) and 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl) -ethanesulfonyl chloride (27.4 mg, 0.10 mmol) were added to 0.034 mmol 45. The reaction mixture was stirred at room temperature for 18 hours under an inert atmosphere. The reaction was monitored by TLC (EtOAc/hexane 3/7) (Rf 44 = 0.5, Rf45 = 0, Rf 268 = 0.4) and LC/MS. After completion of the reaction, the mixture was diluted with EtOAc (20mL) and washed with 1N HCl, saturated NaHCO3 and brine. The organic phase was dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by silica gel chromatography (ethylacetate/hexane-3/7) to afford 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethanesulfonic acid 9-benzhydryloxy-7-(4-fluoro-benzyl)-8-oxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester 268 (12.2 mg, 50%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(1,3-Dioxoisoindolin-2-yl)ethanesulfonylchloride, and friends who are interested can also refer to it.

Reference:
Patent; Gilead Sciences, Inc.; WO2004/35576; (2004); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Sources of common compounds: 2-(1,3-Dioxoisoindolin-2-yl)ethanesulfonylchloride

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(1,3-Dioxoisoindolin-2-yl)ethanesulfonylchloride, and friends who are interested can also refer to it.

4403-36-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4403-36-5 name is 2-(1,3-Dioxoisoindolin-2-yl)ethanesulfonylchloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of p-bromophenethyl bromide (86.87 g, 0.33 mol),Thiourea (30.14 g, 0.396 mol),Anhydrous ethanol (120 ml) was placed in a round bottom flask,Mixed heating reflux,Until there is white precipitation,After filtration,Placed in a single mouth bottle by adding NaOH (135ml, 5M) aqueous solution,Reflow heating for five hours,After dilute hydrochloric acid is acidified,Separating the thiol layer,Dried over anhydrous sodium sulfate,20cm flavor fraction distillation column distillation (distillation range 146-148 ).Bromophenethyl bromide can be obtained by passing 2- (4′-bromophenyl) ethanol to hydrogen bromide.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(1,3-Dioxoisoindolin-2-yl)ethanesulfonylchloride, and friends who are interested can also refer to it.

Reference:
Patent; Beijing Institute of Printing; Wang, Wenguang; Yang, Mingcong; Pu, Jialing; (29 pag.)CN104961665; (2017); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

The important role of 2-(1,3-Dioxoisoindolin-2-yl)ethanesulfonylchloride

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4403-36-5, other downstream synthetic routes, hurry up and to see.

A common compound: 4403-36-5, name is 2-(1,3-Dioxoisoindolin-2-yl)ethanesulfonylchloride, belongs to indolines-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 4403-36-5

To a solution of 2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro- phenyO-ethylJ-beta-aza-bicyclop^.ijoctane-beta-sulfonylJ-ethylamine (100 mg, 0.202 mmol) in dichloromethane / 2N NaOH (2 mL, 1/1) are 2-phtalimidoethanesulfonyl chloride (167 mg, 0.605 mmol). The resulting solution is stirred at 500C during 2h before extraction and evaporation of organic phase to yield the crude compound. It is purified by preparative HPLC (Column Waters C18 ODB 5mum 19×50, Gradient: 0-2.5 min 5% ACN, 2.5-12.5 min 5-100% ACN, 12.5-15 min 100% ACN) to yield title compound. MS: 734 [M+H]+HPLC (Zorbax SB C18, 2min method (0-0.8min 10-95%ACN, 0.8-1.5min 95%ACN, 1.5- 1.6min 95-10%ACN, 1.6-2min 10%ACN): 1.43 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4403-36-5, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2007/115821; (2007); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem