Category: 366453-21-6

Quality Control of 4-Hydroxy-2,3-dihydroisoindol-1-one, The chemical industry reduces the impact on the environment during synthesis 366453-21-6, name is 4-Hydroxy-2,3-dihydroisoindol-1-one, I believe this compound will play a more active role in future production and life.

A solution of DEAD (250 muL, 1.59 mmol) in THF (1 mL) was added dropwise to a solution of 1 h (50.6 mg, 0.17 mmol), Ph3P (54.5 mg, 0.21 mmol) and phenol 2d (24.9 mg, 0.17 mmol) in THF (1.8 mL) at room temperature. After 16 h, the mixture was concentrated under reduced pressure and the residue was purified by flash chromatography (EtOAc/EtOH, 92/8) to give compound 101 (20 mg, 28% yield) as a white solid.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4-Hydroxy-2,3-dihydroisoindol-1-one.

Reference:
Patent; Boehringer Ingelheim (Canada) Ltd.; US2004/106791; (2004); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Adding a certain compound to certain chemical reactions, such as: 366453-21-6, name is 4-Hydroxy-2,3-dihydroisoindol-1-one, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 366453-21-6, HPLC of Formula: C8H7NO2

A solution of DEAD (250 muL, 1.59 mmol) in THF (1 mL) was added dropwise to a solution of 1 h (50.6 mg, 0.17 mmol), Ph3P (54.5 mg, 0.21 mmol) and phenol 2d (24.9 mg, 0.17 mmol) in THF (1.8 mL) at room temperature. After 16 h, the mixture was concentrated under reduced pressure and the residue was purified by flash chromatography (EtOAc/EtOH, 92/8) to give compound 101 (20 mg, 28% yield) as a white solid.

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Reference of 366453-21-6,Some common heterocyclic compound, 366453-21-6, name is 4-Hydroxy-2,3-dihydroisoindol-1-one, molecular formula is C8H7NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

m Synthesis of 2,3-dihydro-1H-isoindol-1-one (32): To a solution of 4-hydroxy isoindolinone 27 (0.100 gm, 0.67 mmol) in methylene chloride (5 ml) and triethylamine (0.2 ml), was added m-nitrobenzoyl chloride (0.125 gm, 0.67 mmol) at 0 C., and the reaction mixture was stirred at room temperature for 5 hr. After the usual workup, the resulting residue was purified by PTLC plate (solvent was 10% methanol-methylene chloride) to give 2,3-dihydro-1H-isoindol-1-one 32 (0.025 mg, 28%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Hydroxy-2,3-dihydroisoindol-1-one, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 366453-21-6, name is 4-Hydroxy-2,3-dihydroisoindol-1-one, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 366453-21-6

k Synthesis of 2,3-dihydro-1H-isoindol-1-one (29): To a solution of 4-hydroxy 2,3-dihydro-1H-isoindol-1-one (27) (0.250 gm, 1.67 mmol) in DMF (5 ml) K2CO3 and was added, followed by addition of methyl bromoacetate, and the reaction mixture was stirred at room temperature for 2hr. Then the reaction mixture was then poured on ice and extracted with ethyl acetate (2*15 ml). After the standard workup, the residue was dissolved in methanol (3 ml), and treated with NaOH (5 ml, 1N) at 0 C. and then stirred for and additional hour. After the standard workup, the solid was recrystallized in methanol to give compound 29 (0.140 gm, 60%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 366453-21-6.

Reference:
Patent; Jagtap, Prakash; Southan, Garry; Salzman, Andrew; Szabo, Csaba; Ram, Siya; US2002/95044; (2002); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem