Category: 35197-64-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35197-64-9, name is 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid, This compound has unique chemical properties. The synthetic route is as follows., name: 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid

Ethyl 2-bromo-4-(1,3-dioxoisoindolin-2-yl)butanoate (17, n=2):5 Thionyl chloride (3.1 mL, 4-5 eq) was dissolved in CCl4. Then Pht-GABA (2.4 g, 10.3 mmol) was added. The slurry was put on oil bath at ~85 oC and refluxed for 1 h 15 min. Everything dissolved within a few minutes. NBS (1.2 eq., 12.36 mmol, 2.2 g) was added to the warm solution forming yellow slurry. On addition of 3 drops of 40% HBr(aq) everything dissolved and solution became red. Reaction mixture was heated under reflux. Within 1 h of reflux in homogenous mixture turned black. After additional 10 min reaction mixture was cooled down, poured into 15 mL of dry EtOH (exothermic), followed by addition of EtOH (2×15 mL). After 10 min it was evaporated to dryness. Product isolated using column chromatography

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 35197-64-9.

Reference:
Article; Coxon, Fraser; Joachimiak, ?ukasz; Najumudeen, Arafath Kaja; Breen, George; Gmach, Joanna; Oetken-Lindholm, Christina; Way, Rebecca; Dunford, James; Abankwa, Daniel; B?azewska, Katarzyna M.; European Journal of Medicinal Chemistry; vol. 84; (2014); p. 77 – 89;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Related Products of 35197-64-9, These common heterocyclic compound, 35197-64-9, name is 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 2-bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid (2) (2.51g; 8.04mmol), thionyl chloride (20mL; 0.27mol) was added and the resulting solution was refluxed for three hours. The excess unreacted thionyl chloride was removed under reduced pressure and the resulting acid chloride was used in the next step as such. To the ice-cooled and stirred solution of the obtained above acid chloride in dry THF (30mL), the N-benzylamine derivative (24.13mmol) was added dropwise and stirring continued for three hours and left overnight. The reaction mixture was poured into ice. The organic layer was washed with dil. HCl and evaporated under vacuum. The aqueous layer was extracted with DCM. The combined organic layers were dried (NaSO4) and concentrated in vacuo. The crude product was finally purified by column chromatography (DCM/acetone 9:1 v/v).

Statistics shows that 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid is playing an increasingly important role. we look forward to future research findings about 35197-64-9.

Reference:
Article; Kowalczyk, Paula; Sa?at, Kinga; Hoefner, Georg C.; Mucha, Marta; Rapacz, Anna; Podkowa, Adrian; Filipek, Barbara; Wanner, Klaus T.; Kulig, Katarzyna; European Journal of Medicinal Chemistry; vol. 83; (2014); p. 256 – 273;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Electric Literature of 35197-64-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35197-64-9, name is 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: In this work, previously reported N-benzyl-2-bromo-4-(1,3-dioxoisoindolin-2-yl)butanamide derivatives (25a-e) [44] were obtained by activating the carboxylic acid group of 24 (1 eqv) by using n-propanephosphonic acid anhydride (T3P, 50% in EtOAc, 1 eqv). The reaction was carried out under argon atmosphere for 2hat 0C in dry methylene chloride. Then, distilled triethylamine (1.2 eqv) and the appropriate N-benzylamine (1.1 eqv) were added to the reaction mixture [57]. The reaction was continued at room temperature for 12h. The products were purified by column chromatography over silica gel (DCM/acetone=9:1) to yield 25a-e as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Article; ?mudzki, Pawe?; Fija?kowski, ?ukasz; Furga?a, Anna; Gryz?o, Beata; Hoefner, Georg C.; Kulig, Katarzyna; Malawska, Barbara; Malawska, Katarzyna; Nowaczyk, Alicja; Podkowa, Adrian; Rapacz, Anna; Sa?at, Kinga; Wanner, Klaus T.; Zar?ba, Paula; European Journal of Medicinal Chemistry; vol. 188; (2020);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem