35197-64-9 Archives - Indolines-derivatives

16-Sep-2021 News Latest chemical Data For 35197-64-9

Application of 35197-64-9, The chemical industry reduces the impact on the environment during synthesis 35197-64-9, name is 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid, I believe this compound will play a more active role in future production and life.

General procedure: In this work, previously reported N-benzyl-2-bromo-4-(1,3-dioxoisoindolin-2-yl)butanamide derivatives (25a-e) [44] were obtained by activating the carboxylic acid group of 24 (1 eqv) by using n-propanephosphonic acid anhydride (T3P, 50% in EtOAc, 1 eqv). The reaction was carried out under argon atmosphere for 2hat 0C in dry methylene chloride. Then, distilled triethylamine (1.2 eqv) and the appropriate N-benzylamine (1.1 eqv) were added to the reaction mixture [57]. The reaction was continued at room temperature for 12h. The products were purified by column chromatography over silica gel (DCM/acetone=9:1) to yield 25a-e as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Article; ?mudzki, Pawe?; Fija?kowski, ?ukasz; Furga?a, Anna; Gryz?o, Beata; Hoefner, Georg C.; Kulig, Katarzyna; Malawska, Barbara; Malawska, Katarzyna; Nowaczyk, Alicja; Podkowa, Adrian; Rapacz, Anna; Sa?at, Kinga; Wanner, Klaus T.; Zar?ba, Paula; European Journal of Medicinal Chemistry; vol. 188; (2020);,
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8-Sep-2021 News Introduction of a new synthetic route about 35197-64-9

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35197-64-9 as follows. Electric Literature of 35197-64-9

4-(4,6-d4-(4,6-Dimethoxy-l,3,5-triazin-2-yl)-4-methylmo holin-4-ium chloride (166 mg, 0.598 mmol) was added to a solution of methyl 3-amino-4-hydroxybenzoate (100 mg, 0.598 mmol) and 2-bromo-4-(l,3-dioxoisoindolin-2-yl)butanoic acid (187 mg, 0.598 mmol) in DMF (5 mL), and the reaction stirred overnight at ambient temperature. The reaction mixture was diluted with ethyl acetate and washed with brine. The organic layer was separated and concentrated to afford methyl 3-(2-bromo-4-(l,3-dioxoisoindolin-2-yl)butanamido)-4-hydroxybenzoate as a thin film which was used directly in the next step without further purification. MS (ESI, m/z): 461, 463 [M+H]+.

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Reference:
Patent; FORMA THERAPEUTICS, INC.; ZHENG, Xiaozhang; NG, Pui, Yee; THOMASON, Jennifer, R.; ZABLOCKI, Mary-Margaret; HAN, Bingsong; BARCZAK, Nicholas; LIU, Cuixian; RUDNITSKAYA, Aleksandra; LANCIA JR., David, R.; BAIR, Kenneth, W.; (315 pag.)WO2017/40963; (2017); A1;,
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Introduction of a new synthetic route about 35197-64-9

Some common heterocyclic compound, 35197-64-9, name is 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid, molecular formula is C12H10BrNO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 35197-64-9

Example 373 (BVT056664); 2-{2-[2-(bicyclo [2.2. 1] hept-5-en-2-ylamino)-4-oxo-4, 5-dihydro-1, 3-thiazol-5-yl] ethyl}- I H-isoindole-1, 3 (2H)-dione; 2-bromo-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid (0.204 g, 0.654 mmol) and N-bicyclo [2.2. 1] hept-5-en-2-ylthiourea (0.112 g, 0.666 mmol) were dissolved in acetone (15 ml) and heated to reflux for 8h. The reaction mixture was allowed to cool to room temperature. NaHCO3 (sat. solution) was added and extraction with DCM was performed. The organic phase was concentrated in vacuum to give the crude product (0.269 g) of which 10 mg was purified using preparative LC-MS (System C, 20-80% MeCN). 7mg, yield ‘H NMR (270 MHz, CHLOROFORM-D) 1.65-1. 84 (m, 4 H) 2.16-2. 37 (m, 1 H) 2.57-2. 73 (m, 1 H) 2.99-3. 11 (m, 2 H) 3.37 (t, J=4. 58 Hz, 1 H) 3.73-3. 88 (m, 1 H) 3.96-4. 12 (m, 1 H) 4.20 (dd, J=10. 27,3. 59 Hz, 1 H) 6.03-6. 10 (m, 1 H) 6.29 (dd, J=5. 69,2. 97 Hz, 1 H) 7.73- 7.81 (m, 2 H) 7.81-7. 91 (m, 2 H) MS (ESI+) for C2oHi9N303S/ 382 (M+H) +

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 35197-64-9, its application will become more common.

Reference:
Patent; BIOVITRUM AB; WO2005/75471; (2005); A2;,
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The origin of a common compound about 35197-64-9

Electric Literature of 35197-64-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35197-64-9, name is 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid, This compound has unique chemical properties. The synthetic route is as follows.

3-(3-chlorophenyl)-2-mercapto-8-methylquinazolin-4(3H)-one (1-3) was prepared as described before . 3-(3-chlorophenyl)-2-mercapto-8-methylquinazolin-4(3H)-one (1-3,211 mg, 0.70 mmol, 1.0 equiv), 2-bromo-4-(l ,3-dioxo-l,3-dihydro-2H-isoindol-2-yl)butanoic acid (3-4, 284 mg, 0.91 ramol, 1.3 equiv.), and triethyl amine (588 muL, 4.2 mmol, 6 equiv.) were dissolved in anhydrous DMF (1 mL) and stirred at 75 0C. When LCMS indicated the reaction was complete, the crude reaction mixture was partitioned between ethyl acetate and 0.1 M HCl, the aqueous phase drained and the organic layer washed twice more with 0.1 M HCl followed by brine to yield the product (3-5). LRMS m/z (M+H) 533.8 found, 533.1 required.

The chemical industry reduces the impact on the environment during synthesis 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid. I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK & CO., INC.; WO2009/102537; (2009); A1;,
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Brief introduction of 35197-64-9

Extracurricular laboratory: Synthetic route of 35197-64-9

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35197-64-9, name is 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

The important role of C12H10BrNO4

Application of 35197-64-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35197-64-9, name is 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

The synthetic route of 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid has been constantly updated, and we look forward to future research findings.

Share a compound : 35197-64-9

Adding a certain compound to certain chemical reactions, such as: 35197-64-9, name is 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35197-64-9, Safety of 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid

Step b: Preparation of tert-but 2-bromo-4-(l,3-dioxo-l,3-dihydro-2H-isoindol-2-yl) butanoate To a solution of compound obtained from Step a (180 mg, 0.576 mmoles) in tetrahydrofuran (5 mL) was added Boc anhydride (1 mL, 0.461 mmoles) and N,N- dimethylaminopyridine (7 mg, 0.057 mmoles). The reaction mixture was allowed to stir at room temperature for about 18 hours. After completion of reaction, solvent was azeotropically distilled using toluene and ethyl acetate to obtain a crude product. The crude product was purified on silica gel column using 20% ethyl acetate: hexane as eluent to get the desired product. Yield: 180 mg

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; RANBAXY LABORATORIES LIMITED; KHERA, Manoj Kumar; PALLE, Venkata P.; SATTIGERI, Viswajanani; SATTIGERI, Jitendra; SONI, Ajay; RAUF, Abdul Rehman Abdul; SIVAKUMAR, R.; REDDY, Ranadheer R.; MUSIB, Arpita; CLIFFE, Ian A.; BHATNAGAR, Pradip Kumar; RAY, Abhijit; SRIVASTAVA, Punit; DASTIDAR, Sunanda Ghosh; WO2012/38944; (2012); A1;,
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Application of 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid

According to the analysis of related databases, 35197-64-9, the application of this compound in the production field has become more and more popular.

Reference of 35197-64-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35197-64-9 as follows.

According to the analysis of related databases, 35197-64-9, the application of this compound in the production field has become more and more popular.

Some tips on 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid

According to the analysis of related databases, 35197-64-9, the application of this compound in the production field has become more and more popular.

Electric Literature of 35197-64-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35197-64-9 as follows.

According to the analysis of related databases, 35197-64-9, the application of this compound in the production field has become more and more popular.