Category: 350797-56-7

Some common heterocyclic compound, 350797-56-7, name is 3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate, molecular formula is C22H23N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C22H23N3O4

A solution of compound XX (30.0 g) in ethyl acetate (300 ml) was charged to an autoclave and 5% platinum on charcoal (50% wet; 12.0 g) were added. The reaction mass was stirred at 25-30C for 8 to 10 h at a hydrogen pressure of 8-10 bar. The resulting suspension was filtered, and the solvent evaporated to afford 25.0 g of the racemic mixture of compound V.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 350797-56-7, its application will become more common.

Reference:
Patent; SANDOZ AG; KUMAR LUTHRA, Parven; BHUTA, Sachin; ABHINAY, Chandrakant Pise; DATTATRAYA, N., Chavan; SHASHIKANT, D., Metkar; WO2013/56842; (2013); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Reference of 350797-56-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 350797-56-7 name is 3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Raw materials (II), hydrochloric acid added to the organic solvent, heated to a certain temperature, slowly adding zinc powder in batch, by thin layer chromatography (TLC) or high performance liquid chromatography (HPLC) to the raw material (II) completely react , The filter cake is washed with a solvent to the product (I), and then subjected to separation and purification by conventional means such as concentration, washing, drying,To give the salt of the compound (I), which is obtained by alkalizing the free base of (I).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate, and friends who are interested can also refer to it.

Reference:
Patent; Changzhou Ruiming Pharmaceutical Co., Ltd.; Shi Weiming; (5 pag.)CN106928118; (2017); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Adding a certain compound to certain chemical reactions, such as: 350797-56-7, name is 3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 350797-56-7, HPLC of Formula: C22H23N3O4

Procedure-2: To a stirring solution of 3-(7-Cyano-5-(2-nitropropyl)-indolin-l-yl)- propyl benzoate of Formula XII (10 g, 25.4mmol) in methanol (50 ml) was added con. HC1 (10 ml) followed by Zn (3.35 g, 50.08mmol). The mixture was heated to 60-65 C for 20 h. After completion of the reaction, the mixture was filtered and the residue was washed with Methanol (5 ml). The filtrate was concentrated under vacuum and the residue was dissolved in water and washed with isopropyl ether (2×20 ml). The MDC (80 ml) was added to the aqueous layer and basified the mixture by adding aqueous 20% NaOH solution. The obtained solid slurry mass was filtered and both the layers were separated from the filtrate. The organic layer was washed twice with water (2 x 100 ml) and concentrated under vacuum to get 8.5 g of 3-(5-(2-aminopropyl)-7- cyanoindolin-l-yl)propyl benzoate of Formula XII as a thick mass (HPLC purity is -abo-ve-95-%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PANACEA BIOTEC LTD; JAIN, Rajesh; RAO, Jagadeeshwar R; RAO, Siripragada Mahender; WO2012/131710; (2012); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Related Products of 350797-56-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 350797-56-7, name is 3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate, This compound has unique chemical properties. The synthetic route is as follows.

To the solution of 394g of 3-(7-cyano-5-(2-nitropropyl)indolin-l-yl)propyl benzoate in 2000ml of methanol and 800ml of ethyl acetate was added 39.4g of palladium hydroxide in an autoclave. Heated the reaction mass under hydrogen pressure of lOkg/cm3 at 50-55C till completion of reaction. Filtered the catalyst and concentrated the filtrate to get 346g of desired amino compound.

The chemical industry reduces the impact on the environment during synthesis 3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; MANKIND RESEARCH CENTRE; SINGH, Gurpreet; GANGWAR, Kuldeep Singh; BHASHKAR, Bhuwan; KUMAR, Anil; WO2014/167507; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Related Products of 350797-56-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 350797-56-7, name is 3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Example 360 mg of compound A was dissolved in 50 ml MeOH and was reduced using 10% Pd/C catalyst in a commercial H-Cube reactor. Solution was passed through catalyst cartridge at 40C at a rate of 1 ml/min. Pressure = 1 bar.Reaction was complete in 60 minutes. Solution was concentrated to give 37 mg (67% yield) of product. HNMR was satisfactory.

The synthetic route of 3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RATIOPHARM GMBH; GIDWANI, Ramesh Matioram; KOLHATKAR, Mayur Vilas; WO2011/124704; (2011); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem