Category: 3484-35-3

3484-35-3, Adding a certain compound to certain chemical reactions, such as: 3484-35-3, name is 5-Methylindolin-2-one, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3484-35-3.

General procedure: The reaction mixture of the substituted oxindole (1 equiv), the substituted salicylaldehyde (1.2 equiv) and piperidine (0.1 equiv) in ethanol (1-2 mL/1 mmol) was stirred at 90 C for 3-5 h. After the reaction mixture cooled down, the precipitate was filtered and washed with cold ethanol and diethyl ether, successively. Allowed to dry, the product was used in subsequent reaction without further purification.

According to the analysis of related databases, 3484-35-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhang, Lidan; Ren, Wen; Wang, Xiaoyan; Zhang, Jiaying; Liu, Jie; Zhao, Lifeng; Zhang, Xia; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 1071 – 1082;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Some common heterocyclic compound, 3484-35-3, name is 5-Methylindolin-2-one, molecular formula is C9H9NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 3484-35-3

4-(2-Carboxyethyl)-2-formyl-3-methylpyrrole (90 mg), 74 mg 5-methyl-2-oxindole, and 75 muL piperidine in 2 mL of ethanol were heated at 95 C. for 5 hours. The reaction mixture was cooled and concentrated. The residue was suspended in 6 N aqueous hydrochloric acid. The precipitate was filtered, washed with water to pH 6 and dried in a vacuum oven to give 65 mg (42%) of the title compound as a brown solid. 1H-NMR (360 MHz, DMSO-d6): delta 13.30 (s, br, 1 H, NH-1′), 12.05 (s, br, 1 H, COOH), 10.67 (s, br, 1 H, NH-1), 7.57 (s, 2 H, H-vinyl, H-4), 7.12 (d, J=2.65 Hz, 1 H, H-2′), 6.91 (d, J=7.82 Hz, 1 H, H-6), 6.74 (d, J=7.82 Hz, 1 H, H-7), 2.65 (t, J=6.94 Hz, 2 H, CH2CH2COOH), 2.46 (t, J=6.94 Hz, 2 H, CH2CH2COOH), 2.30 (s, 3 H, CH3), 2.25 (s, 3 H, CH3); MS m/z (relative intensity, %) 311 ([M+1]+, 100).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3484-35-3, its application will become more common.

Reference:
Patent; Sugen, Inc.; US6395734; (2002); B1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

3484-35-3, name is 5-Methylindolin-2-one, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 3484-35-3

General procedure: A mixture of compound 4 (10 mmol), benzaldehyde (12 mmol) and afew drops of piperidine in ethanol (100 mL) was refluxed for 2 h. Partof the solvent was evaporated under reduced pressure and the residue was cooled to room temperature to crystallise the solid product,which was filtered off, washed twice with ethanol, and dried to yield compound 5.

Statistics shows that 3484-35-3 is playing an increasingly important role. we look forward to future research findings about 5-Methylindolin-2-one.

Reference:
Article; Jiang, Hongwu; Feng, Zhiyuan; Chen, Taiping; Li, Zicheng; Huang, Wencai; Luo, Youfu; Zhao, Yinglan; Journal of Chemical Research; vol. 42; 1; (2018); p. 44 – 49;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

3484-35-3, Name is 5-Methylindolin-2-one, 3484-35-3, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

General procedure: To a solution of s7 (398 mg, 1.18 mmol) in EtOH (2.30 mL) were successively added addedoxindole (105 mg, 1.13 mmol) and piperidine (12 muL, 0.12 mmol) at room temperature. After 20 h,the reaction mixture was concentrated in vacuo. The residue was purified by columnchromatography (silica gel, hexane/EtOAc = 4/1) to afford aldehyde 1a (422 mg, 84%) as yellowsolid, whose geometry was determined by X-ray crystal analysis.

Statistics shows that 5-Methylindolin-2-one is playing an increasingly important role. we look forward to future research findings about 3484-35-3.

Reference:
Article; Machida, Mizuki; Mori, Keiji; Chemistry Letters; vol. 47; 7; (2018); p. 868 – 871;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3484-35-3 name is 5-Methylindolin-2-one, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 3484-35-3

General procedure: Equimolar quantity of 5-substituted-1H-indolin-2-ones and 2-(4-formylphenoxy)-N-substituted-phenyl-acetamide was taken into round bottom flask containing 50 mL of methanol, followed by 2-3 drops of piperidine. The reaction mixture was refluxed for 1-4 h or till the end of reaction as confirmed by TLC. Then, it was cooled to room temperature and, the solution was filtered. The obtained residue was recrystallized by using dimethylformamide and ethanol.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Methylindolin-2-one, and friends who are interested can also refer to it.

Reference:
Article; Bhadauria, Vivek Singh; Sravanthi, Vishnu; Kumar, Sujeet; Das, Debajyoti; De Clercq, Erik; Schols, Dominique; Tokuda, Harukuni; Karki, Subhas S.; Acta poloniae pharmaceutica; vol. 74; 1; (2017); p. 137 – 145;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem