Related Products of 304876-29-7, A common heterocyclic compound, 304876-29-7, name is 2′,3′,5′,6′-Tetrahydrospiro[indoline-3,4′-pyran]-2-one, molecular formula is C12H13NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Sodium hydride (8.00 mg of a 60% dispersion in mineral oil, 0.207 mmol) was added to a solution of 2′,3′,5′,6I-tetrahydrospiro[indole-3,4′-pyran]-2(lH)-one from Step A (35.0 mg, 0.172 mmol) in DMF (1 mL) at 0 0C. After 1 hr, tert-butyl bromoacetate (0.280 mL, 0.189 mmol) was added and the reaction warmed to ambient temperature. After 18 h, the reaction was partitioned between CH2Cl2 (10 mL) and saturated NH4CI (10 mL). The organic layer was dried over Na2SO4, filtered, and concentrated in vacuo to give the title compound. MS: m/z = 318 (M + 1).
The synthetic route of 304876-29-7 has been constantly updated, and we look forward to future research findings.