Category: 2913-97-5

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2913-97-5, name is N-(2-Oxoethyl)phthalimide, This compound has unique chemical properties. The synthetic route is as follows., 2913-97-5

Step 2: A mixture of aniline 107 (1 37 g, 6 7 mmol), 2-(l,3-dioxoisoindohn-2-yl)acetaldehyde (108)(1 26 g, 6 7 mmol), sodium tnacetoxyborohydnde (2 1 g, 10 05 mmol), and acetic acid (0 04 g, 6 7 mmol) in dry dichloromethane under argon was stirred at room temperature for 2 h The reaction mixture was washed with saturated aqueous NaHCO3, water, and brine The combmed organics were dried over Na2SO4 filtered, and concentrated under reduced vacuum Flash chromatography (0-60percent EtOAc – hexanes gradient), gave the secondary aniline 109 as a yellow oil Yield (1 6 g, 64percent) 1H NMR (400 MHz, CDCl3) delta 7 80 – 7 85 (m, 2H), 7 66 – 6 72 (m, 2H), 7 01 (t, J = 6 Hz, IH)1 6 18 – 6 22 (m, 2H), 6 14 – 6 18 (m, IH), 4 05 (br s, IH), 3 95 (t, J= 6 0 Hz, 2H), 3 68 (d, /= 6 4 Hz, 2H), 3 41 (t, J= 6 4 Hz, 2H), 1 80 – 1 88 (m, 2H), 1 64 – 1 78 (m, 4H), 1 12 – 1 34 (m, 3H), 0 96 – 1 08 (m, 2H)

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Reference:
Patent; ACUCELA INC.; WO2009/45479; (2009); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

2913-97-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2913-97-5, name is N-(2-Oxoethyl)phthalimide belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of S-I-Il (6.26 g) and TEA (10.04 g) in dichloromethane (100 mL) at 5-10 ¡ãC was added hydroxylamine hydrochloride (2.53 g). The mixture was stirred at room temperature for 15 h and then quenched with NH4C1(aq) (50 mL, 2M). The aqueous phase was extracted with CH2C12 (2×50 mL). The combined organic NaHCO3(aq)sulfate, filtered. The filtrate was concentrated to get the crude product S-I-Ill (4.01 g, y: 59percent).

The synthetic route of 2913-97-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NATIONAL HEALTH RESEARCH INSTITUTES; SHIH, Chuan; SHIA, Kak-Shan; WU, Chien-Huang; CHOI, Ming-Chen; SONG, Jen-Shin; WANG, Yun; (84 pag.)WO2018/132326; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

These common heterocyclic compound, 2913-97-5, name is N-(2-Oxoethyl)phthalimide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 2913-97-5

General method for the synthesis of compound 7: Phthalimidoacetaldehyde 4 (0.378 g, 2 mmol) was dissolved in 6 mL of acetonitrile. To this solution added 6-bromoindole 5a (0.780 g, 2 mmol), barbituric acid 6 (0.312 g, 2 mmol), and catalytic amount of D-L-Proline under nitrogen atmosphere. The reaction mixture was stirred at room temperature for 24 h. The resulting suspension was filtered and the precipitate was washed with acetonitrile (2 .x. 50 mL) to obtain a white compound 7a. The product 7a was obtained in a 95percent yield (1.00 g), m.p 107-108 ¡ãC. 1H NMR (300 MHz, CDCl3): delta 2.84 (s, 3H), 3.05 (s, 3H), 3.86 (d, 1H), 4.33 (m,1H), 4.70 (d, 2H), 7.05-8.01 (m, 8H), 8.23 (br s, 1H). Similarly compound 7b-c were synthesised and characterised.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2913-97-5.

Reference:
Article; Seetham Naidu; Bhuyan, Pulak J.; Tetrahedron Letters; vol. 53; 4; (2012); p. 426 – 428;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem