Category: 2913-97-5

SDS of cas: 2913-97-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2913-97-5 as follows.

Compound 2: NaBH(OAc)3 (3,05 g ;14,4 mmol) was added to a solution of N- ethylaniline (1,16 g ; 9,6 mmol) and 2-phthalimidoacetaldehyde (1) (2,72 g, 14,4 mmol) in CH2C12 (28 mL). After 24 h at 20°C, CH2C12 was added and the organic phase was washed with H20, dried (MgS04) and evaporated. The crude product was purified by chromatography over silica gel (80:20 CH2Cl2-cyclohexane) to afford 2 as a yellow solid (2,71 g, 96 percent). 1H NMR (250 MHz, CDC13): delta 7,85 (m, 2H), 7,71 (m, 2H), 7.24 (t, J = 7,8 Hz, 2H), 6,86 (d, J = 7,8 Hz, 2H), 6.67 (t, J = 7,8 Hz, 1H), 3.91 (dd, J = 6,5, 8,1 Hz, 2H), 3,58 (dd, J = 6,5, 8,1 Hz, 2H), 3,46 (q, J = 6,9 Hz, 2H), 1.22 (t, J = 7,0 Hz, 3H). 13C NMR (63 MHz, CDC13): <5 168,0 (C), 147,2 (C), 133,7 (CH), 131 ,8 (C), 129,2 (CH), 123,0 (CH), 116,0 (CH), 111,9 (CH), 47,8 (CH2), 44,6 (CH2), 35,0 (CH2), 12,2 (CH3). MS: m/z = 295 (MH+). Anal, calcd for Ci8Hi8N202 (294,14), C 73.45, H 6,16, N 9,52. Found C 73,33, H 6,17, N 9,62. I am very proud of our efforts over the past few months and hope to 2913-97-5 help many people in the next few years. Reference:
Patent; UNIVERSITE PARIS DESCARTES; SLAMA-SCHWOK, Anny; BOUCHER, Jean-Luc; XU-LI, Yun; DEPREZ, Eric; HENRY, Etienne; DESSY, Chantal; FERON, Olivier; TARUS, Bogdan; WO2012/175516; (2012); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2913-97-5, name is N-(2-Oxoethyl)phthalimide, A new synthetic method of this compound is introduced below., Product Details of 2913-97-5

A solution of the product of Example 3E (9.34 g, 49.4 mmol) in methanol (33 mL) was treated with L-tert-leucine tert-butyl ester hydrochloride (10 g, 44.9 mmol), sodium cyanoborohydride (5.6 g, 89.8 mmol), and acetic acid (1.5 ml, 26.2 mmol), stirred at 25° C. for 4 hours, and partitioned between chloroform and saturated NaHCO3. The organic phase phase was washed with brine, dried over MgSO4, filtered and concentrated. The residue was chromatographed in silica gel, eluting with first with 66percent chloroform in hexanes and then with 33percent ethyl acetate in chloroform to give the title compound (10.5 g, 59percent yield).

We are continuing to develop the new Research Structures and WebCSD systems in response to feedback from you, our user community, so we would love to hear what you think about the enhanced search functionality and any suggestions you might have about 2913-97-5.

Reference:
Patent; DeGoey, David A.; Flentge, Charles A.; Flosi, William J.; Grampovnik, David J.; Kempf, Dale J.; Klein, Larry L.; US2005/131017; (2005); A1;,
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COA of Formula: C10H7NO3, Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment.

To a stirred solution of 9 (0.38mmol) in MeOH (2mL), NH4OAc (3.76mmol), 2-(1,3-dioxoisoindolin-2-yl)acetaldehyde (10) (0.56mmol), and MTBE (2mL) were added at room temperature. The mixture was heated at 50°C for 10h and then cooled to room temperature. The pH of the reaction mixture was adjusted to 8 with saturated aqueous NaHCO3 solution. The reaction mixture was extracted with EtOAc (2×35mL), and the combined organic layer was washed with water (10mL) and brine (10mL). The EtOAc solution was dried over anhydrous Na2SO4, filtered, and evaporated to dryness under reduced pressure. The residue was purified by MPLC on silica gel using MeOH/ CH2Cl2 (1:20) as eluent to give the titled compound as a yellow solid. Yield 67percent; mp 262?263°C; IR (KBr) 3076, 2928, 1716, 1391cm?1; 1H NMR (400MHz, CDCl3/CD3OD) delta 2.51 (s, 3H), 5.00 (s, 2H), 7.00 (d, 1H, J=7.6Hz), 7.10 (d, 1H, J=8.0Hz), 7.42 (t, 1H, J=7.8Hz), 7.67 (d, 1H, J=9.2Hz), 7.69?7.72 (m, 2H), 7.74 (dd, 1H, J=9.2, 1.6Hz), 7.83?7.86 (m, 2H), 8.28 (s, 1H), 8.87 (br s, 1H); 13C NMR (100MHz, CDCl3) delta 24.6, 35.5, 116.3, 117.7, 122.2, 122.8, 123.9 (2C), 128.0, 128.9, 131.7, 132.1 (2C), 134.2, 134.6 (2C), 137.3, 143.3, 147.7, 150.0, 154.5, 159.1, 168.1 (2C); HRMS-ESI: m/z [M+H]+ calcd for C24H18N7O2: 436.1516, found 436.1530.

We are continuing to develop the new Research Structures and WebCSD systems in response to feedback from you, our user community, so we would love to hear what you think about the enhanced search functionality and any suggestions you might have about 2913-97-5.

Reference:
Article; Jin, Cheng Hua; Krishnaiah, Maddeboina; Sreenu, Domalapally; Subrahmanyam, Vura Bala; Park, Hyun-Ju; Park, So-Jung; Sheen, Yhun Yhong; Kim, Dae-Kee; Bioorganic and Medicinal Chemistry; vol. 22; 9; (2014); p. 2724 – 2732;,
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Synthetic Route of 2913-97-5, A common heterocyclic compound, 2913-97-5, name is N-(2-Oxoethyl)phthalimide, molecular formula is C10H7NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of Example 32A (12.1 g) in methanol (20 mL) was added L-isoleucine tert-butyl ester hydrochloride (13.0 g, 58 mmol), sodium cyanoborohydride (7.3 g, 116 mmol), and acetic acid (2 mL). The resulting solution was stirred for 3 hrs at 25° C. and the methanol removed under vacuum, dichloromethane (500 mL) added, and the solution extracted with aq. NaHCO3 (2.x.300 mL). Evaporation and purification of the organic layer gave 12.9 g of the title compound.

The synthetic route of 2913-97-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Flentge, Charles A.; Chen, Hui-Ju; DeGoey, David A.; Flosi, William J.; Grampovnik, David J.; Huang, Peggy P.; Kempf, Dale J.; Klein, Larry L.; Krueger, Allan C.; Madigan, Darold L.; Randolph, John T.; Sun, Minghua; Yeung, Ming C.; Zhao, Chen; US2005/131042; (2005); A1;,
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2913-97-5, name is N-(2-Oxoethyl)phthalimide, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 2913-97-5

Under a nitrogen atmosphere, to a mixture of NaH (560 mg, 22 mmol) and anhydrous THF (90 mL), a solution of diethyle(2-oxopropyl)phosphonate (4.27 g, 22 mmol) in THF (60 mL) was added over 10 min. The resulting solution was stirred at r.t. for 1 h. Then Compound 2 (6.24 g, 33 mmol) was dissolved in THF (30 mL) and was added dropwise to the above solution. The reaction mixture was stirred at r.t. for a further 3 h. The reaction was quenched with H2O, and THF was removed in vacuo. The residue was then extracted with CH2Cl2 and the combined organic layer was washed with 1N HCl and saturated NaHCO3, dried over Na2SO4. The solvent was evaporated and the residue was purified by silica gel column chromatography with Hexane/EtOAc (1:1) to provide Compound 3 (4.6 g, 20 mmol, 60percent) as a white solid. 1H NMR (CDCl3, 400 MHz) delta 7.91 (m, 2H), 7.79 (m, 2H), 6.81-6.74 (m, 1H), 6.16-6.11(dt, J=1.6, 16.0 Hz, 1H), 4.49 (dd, J=1.6, 4.8 Hz, 2H), 2.27 (s, 3H); 13C NMR (CDCl3, 100 MHz): delta 197.7, 167.7, 139.7, 134.4, 131.9, 131.8, 123.7, 123.6, 38.3, 27.2; MS (ESI, positive) m/z calcd. for C13H12NO3 [M+H]+: 230, found: 230.

The synthetic route of 2913-97-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITY OF DELAWARE; Zhuang, Zhihao; Li, Guorui; (15 pag.)US9605297; (2017); B2;,
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Some common heterocyclic compound, 2913-97-5, name is N-(2-Oxoethyl)phthalimide, molecular formula is C10H7NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 2913-97-5

Aldehyde reaction partner selection was key in order to assign donor and acceptor roles to aldehydes in the previously discussed aldol reaction. Aldol reactions between Compound 1 and oc-non-branched aldehydes such as isovaleraldehyde and hexanal afforded P-hydroxy-y- (diprotected) amino aldehydes Compounds 6 under identical conditions to those used in Table 5 (see, Scheme 10, hereinbelow, wherein R is a non-branched substituent containing at least two hydrogen atoms) . No formation of (3-hydroxy-a-amino aldehydes was detected. In these instances, aldehyde Compound 1 acted as the acceptor. Slow addition of aldehyde Compound 1 to isovaleraldehyde in thepresence of the catalyst did not change the outcome of the reaction.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2913-97-5, its application will become more common.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; WO2006/23720; (2006); A2;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2913-97-5, name is N-(2-Oxoethyl)phthalimide, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C10H7NO3

To a solution of (1 ,3-dioxo-1 ,3-dihydro-isoindol-2-yl)-acetaldehyde (4.53 g) in EtOH (18 mL) was added a solution of 2-aminoethanthiol hydrochloride (2.9 g) in water (3.7 mL) followed by addition in one portion of potassium acetate (2.5 g). The reaction mixture was stirred at rt for 2 h and poured into a sat. NaHCO3 solution, the resulting precipitate was collected by filtration and washed with water and EtOH to yield the title compound as a white solid (4.92 g, 82percent).LC-MS: tR = 0.57 min; [M+H]+ = 248.95

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2913-97-5.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOSS, Christoph; HAZEMANN, Julien; KOBERSTEIN, Ralf; SIEGRIST, Romain; SIFFERLEN, Thierry; WO2010/4507; (2010); A1;,
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Reference of 2913-97-5,Some common heterocyclic compound, 2913-97-5, name is N-(2-Oxoethyl)phthalimide, molecular formula is C10H7NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate B3-2-(1,3-dioxoisoindolin-2-yl)acetaldehyde oxime A mixture of intermediate B2 (1.46g, 1equiv), hydroxylamine hydrochloride (0.64g, 1.2equiv), anhydrous K2CO3 (1.6g, 1.5equiv) in absolute methanol (10ml) was stirred at room temperature overnight. The solvent was evaporated under reduced pressure and the residue was diluted with water, extracted with dichloromethane three times. The organic phase was combined and washed with brine, dried and solvent evaporated to give the title compound as a white solid (0.75g). 1H-NMR (d6-DMSO, 400 MHz, ca 1:1 cis-trans isomer) delta4.30/4.37 (2x d, 2H, J=4.0), 6.81/7.35 (2x t, 1H, J=4.0), 7.81-7.88 (m, 4H), 10.86/11.34 (2x s, 1H); MS (EI) m/z: 204 (M+).

The synthetic route of 2913-97-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; SHEN, Jianhua; WANG, Yiping; WANG, Kai; EP2725024; (2014); A1;,
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Reference of 2913-97-5, These common heterocyclic compound, 2913-97-5, name is N-(2-Oxoethyl)phthalimide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 2: NaBH(OAc)3 (3,05 g ;14,4 mmol) was added to a solution of N-ethylaniline (1,16 g ; 9,6 mmol) and 2-phthalimidoacetaldehyde (1) (2,72 g, 14,4 mmol) in CH2Cl2 (28 mL). After 24 h at 20°C, CH2Cl2 was added and the organic phase was washed with H2O, dried (MgSO4) and evaporated. The crude product was purified by chromatography over silica gel (80:20 CH2Cl2-cyclohexane) to afford 2 as a yellow solid (2,71 g, 96 percent). 1H NMR (250 MHz, CDCl3): delta 7,85 (m, 2H), 7,71 (m, 2H), 7.24 (t, J = 7,8 Hz, 2H), 6,86 (d, J = 7,8 Hz, 2H), 6.67 (t, J = 7,8 Hz, 1H), 3.91 (dd, J = 6,5, 8,1 Hz, 2H), 3,58 (dd, J = 6,5, 8,1 Hz, 2H), 3,46 (q, J = 6,9 Hz, 2H), 1.22 (t, J = 7,0 Hz, 3H). 13C NMR (63 MHz, CDCl3): delta 168,0 (C), 147,2 (C), 133,7 (CH), 131,8 (C), 129,2 (CH), 123,0 (CH), 116,0 (CH), 111,9 (CH), 47,8 (CH2), 44,6 (CH2), 35,0 (CH2), 12,2 (CH3). MS: m/z = 295 (MH+). Anal. calcd for C18H18N2O2 (294,14), C 73.45, H 6,16, N 9,52. Found C 73,33, H 6,17, N 9,62.

The synthetic route of 2913-97-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Universite Paris Descartes; EP2537855; (2012); A1;,
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Adding a certain compound to certain chemical reactions, such as: 2913-97-5, name is N-(2-Oxoethyl)phthalimide, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2913-97-5, SDS of cas: 2913-97-5

Example 12d (0.4 g, 0902 mmol) and 2-(l,3-dioxo onidQlm-2- i)acetaldehyde (0.683 g, 3 J61 mmol) were combined in tetral^drof ran (9 J02 mL) under nitrogen , cooled to 0 * C and treated drop-wise with 1M ntaniuin(I V) chloride in die hloro me thane (3 J61 mL, 3.61 mmol) to give an opaque red solution. The sotitionwas stirred for 72 hours at ambient temperature and partitioned b etween ethyl acetate and water. The organic layer was was hed with s aturated aqueous s odium chloride, dried over arLhydrous sodium sulfate, filtered and concentrated. -ificationby chromatography (siEca gel, 0.5-5percent methanol in dichloiomethane) afforded the title confound as a yellow powder (0.45 g, 81percent). NMR (500 MHz, DMS 0-^) 6 1 1.78 ^, ; = 1 S3 Hz, 1 7.93 (d, J = 1 .53 Hz, 1H), 7B1 – 7.85 (m, 4 7.76 (s, l H), 7.24 – 7.30 (m, 1 H), 721 (dd, J = 824, 1.83 Hz, 1H), 7.09 – 7.15 (m, 1H) 699 – 7.05 (m, 1 6.96 (d, J = 2.44 Hz, 1 HI 6.92 (d, J = 824 Hz, 1 HI 5.44 (dd, J = 9.92, 5 4 Hz, 1 HI 4.51 – 4.56 (m, 1H), 4.44 – 4.48 (m, 1 3.87 (dd, J = 13.28, 5.34 Hz, 1 HI 3 J66 (S, 3H), 3 2 (dd, J = 13.28, 10.22 Hz, 1H), 2.98 (s, 3H) . Xi (EpsilonXi 1+) m/z 615 (M+H) 1.

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Reference:
Patent; ABBVIE INC.; ABBVIE PHARMACEUTICAL TRADING (SHANGHAI) CO., LTD.; FIDANZE, Steven D.; LIU, Dachun; MANTEI, Robert A.; MCDANIEL, Keith F.; PRATT, John; SHEPPARD, George S.; WANG, Le; BOGDAN, Andrew; HOLMS, James H.; DIETRICH, Justin D.; MARJANOVIC, Jasmina; HASVOLD, Lisa A.; DAI, Yujia; WO2014/139324; (2014); A1;,
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