25369-33-9 Archives - Indolines-derivatives

28-Sep-2021 News Why Are Children Getting Addicted To 25369-33-9

In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system., Product Details of 25369-33-9

To a coo?ed (0 C) soution of 7-choroindohn-2-one (1 g, 6.0 mmo) in TFA (11 mL) was added Nbromosuccinimide (1 g, 6.0 mmo) portion wise and stirred the mixture at same temperature for 6 h. Concentrated TFA in vacuo with DCM (25 mL) and then with EtOAc. The crude product was triturated with ethano to provide the tiDe compound as a white soid (861 mg, 58% yie?d). MS (ES):mass cacd, for C6H5BrCNO, 244.9; m/z found, 246.0 [M+H]. 1H NMR (500 MHz, DMSO d6) oe 10.92 (5, 1 H), 7.52 7.48 (m, I H), 7.38 (d, J = 1.2 Hz, I H), 3.62 (s, 2H).

This is the end of this tutorial post, and I hope it has helped your research about 25369-33-9.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; AMERIKS, Michael K.; RAVULA, Suchitra; SAVALL, Bradley M.; SWANSON, Devin M.; ZIFF, Jeannie M.; SHIREMAN, Brock T.; (167 pag.)WO2016/176463; (2016); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

6-Sep-2021 News Brief introduction of 25369-33-9

Electric Literature of 25369-33-9,Some common heterocyclic compound, 25369-33-9, name is 7-Chloroindolin-2-one, molecular formula is C8H6ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: An oven-dried flask was charged with stir bar, oxindole (0.5 mmol), PIDA (0.25 mmol) in dry acetonitrile (4.0 mL). Then to the reaction mixture TEMPO (0.5 mmol) was added in presence of air and the mixture was stirred at room temperature until complete conversion takes place as indicated by TLC analysis. The resulting reaction mixture was extracted with ethyl acetate (3 10 mL). The combined organics were dried with Na2SO4 and dried under vacuum to afford crude solid. Then the crude product was purified by column chromatography on silica gel.

The synthetic route of 25369-33-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sai Prathima, Parvathaneni; Bikshapathi, Raktani; Rao, Vaidya Jayathirtha; Tetrahedron Letters; vol. 56; 46; (2015); p. 6385 – 6388;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Analyzing the synthesis route of 25369-33-9

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25369-33-9 as follows. name: 7-Chloroindolin-2-one

To a suspension of AlCl3 (13.4 g, 0.10 mol) in methylene chloride (40 mL) is added a solution of 7-Chlorooxindole (0.10 mol) and chloroacetyl chloride (8 mL, 0.10 mol) at 0 C. The solution is warmed to ambient temperature for two hours and poured onto ice and extracted with methylene chloride, washing with saturated bicarbonate solution, brine, and drying over MgSO4 would provide the desired chloroketone.

According to the analysis of related databases, 25369-33-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Wittman, Mark D.; Balasubramanian, Neelakantan; Velaparthi, Upender; Zimmermann, Kurt; Saulnier, Mark G.; Liu, Peiying; Sang, Xiaopeng; Frennesson, David B.; Stoffan, Karen M.; Tarrant, James G.; Marinier, Anne; Roy, Stephan; US2004/44203; (2004); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Extended knowledge of 25369-33-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25369-33-9, name is 7-Chloroindolin-2-one, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 25369-33-9

To a cooled (0 C.) solution of 7-chloroindolin-2-one (1.0 g, 6.0 mmol) in TFA (11 mL) was added N-bromosuccinimide (1.0 g, 6.0 mmol) portion wise, and the resulting mixture was stirred at 0 C. for 6 h. The solvent was removed in vacuo and the residue was diluted and evaporated successively with DCM (25 mL) and EtOAc (25 mL). The crude product was triturated with EtOH to provide the title compound as a white solid (861 mg, 58% yield). MS (ESI): mass calcd. for C8H5BrClNO, 244.9; m/z found, 246.0 [M+H]+. 1H NMR (500 MHz, DMSO-d6) delta 10.92 (s, 1H), 7.52-7.48 (m, 1H), 7.38 (d, J=1.2 Hz, 1H), 3.62 (s, 2H).

According to the analysis of related databases, 25369-33-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Janssen Pharmaceutica NV; Ameriks, Michael K.; Laforteza, Brian Ngo; Lebold, Terry Patrick; Ravula, Suchitra; Savall, Brad M.; Shireman, Brock T.; (70 pag.)US2018/111942; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

New learning discoveries about C8H6ClNO

Adding a certain compound to certain chemical reactions, such as: 25369-33-9, name is 7-Chloroindolin-2-one, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25369-33-9, Quality Control of 7-Chloroindolin-2-one

Example 24; Preparation of (Z)-3-(azulen-1-ylmethylene)-7-chloroindolin-2-one(042); 0.3519g 7-chlorooxindole (0.0021mole) and 0.323g azulene aldehyde (0.0021mole) were dissolved in 30mL dried ethanol. 1.5mL pyrrolidine (1M) was then added and uniformly stirred at reflux temperature for two hours. After removal of dried ethanol, the results were extracted by dichloromethane and citric acid aqueous solution. The organic layer was collected, dried with anhydrous magnesium sulfate, filtered, concentrated under vacuum, and separated by silica gel column chromatography to give Z-form Compound 042 (0.3693g). The total weight of 7-chlorooxindole-azulene was 0.3693g (57.56%). 042 (500 MHz, DMSO-d6) delta (ppm) 10.89 (s, 1H), 9.75 (d, J=4.5 Hz, 1H), 9.25 (d, J=10.0 Hz, 1H), 8.57 (d, J=10.0 Hz, 1H), 8.48 (s, 1H), 7.97 (d, J=7.5 Hz, 1H), 7.94 (t, J=10.0 Hz, 1H), 7.61 (t, J=10.0 Hz, 1H), 7.60 (d, J=4.5 Hz, 1H), 7.55 (t, J=10.0 Hz, 1H), 7.20 (d, J=7.5 Hz, 1H), 7.03 (d, J=7.5 Hz, 1H). LC-MS (m/z) 306 [M+1].

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Industrial Technology Research Institute; EP1918277; (2008); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Analyzing the synthesis route of C8H6ClNO

These common heterocyclic compound, 25369-33-9, name is 7-Chloroindolin-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 7-Chloroindolin-2-one

General procedure: A mixture of 2a-j (1.50 mmol) and 5 (1.50 mmol) in ethanol (10 mL) was treated with a catalytic amount of piperidine. The reaction mixture was stirred under reflux until complete consumption of the substituted indolin-2-ones was observed by TLC. After cooling, the precipitate was filtered, recrystallised from absolute ethanol and dried in air to furnish pure (E)-3-(benzothiazol-2-ylmethylene)indolin-2-ones 6a-j.

The synthetic route of 7-Chloroindolin-2-one has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Chao; Xu, Juan; Zhao, Xinyu; Kang, Congmin; Journal of Chemical Research; vol. 41; 9; (2017); p. 537 – 540;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Analyzing the synthesis route of C8H6ClNO

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25369-33-9, name is 7-Chloroindolin-2-one, A new synthetic method of this compound is introduced below., name: 7-Chloroindolin-2-one

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Simple exploration of C8H6ClNO

Example 54Preparation of 7-chloro-5-[Y2-((‘l S,2S)-2-[l-(5-chloropyrimidin-2-yl)piperidin-4- yli cvclopropyU ethvDaminol -1.3 -dihvdro-2H-indol-2-oneStep 1 ; 7-chloro-5-nitro-13-dihvdro-2H-indol-2-one7-chloro-1,3-dihydro-2H-indol-2-one (8.Og, 47.7 mmol) was slurried in H2SO4 (cone, 86 ml) and the mixture cooled to -45 C. A solution of fuming nitric acid (>90%, 3.34 g, 52.9 mmol) in H2SO4 (20 ml) was added drop wise, while maintaining the temperature at -45 C throughout the addition. The mixture was allowed to slowly warm to RT and stirred overnight. The mixture was poured into stirred ice-cold water (1500 ml). A white precipitate resulted, and the slurry was aged at 0 C for 1 hour. The solid was collected by filtration, triturated with cold water (2x)? and dissolved into EtOAc (1 L). This mixture was filtered, washed with basic brine (containing sodium bicarbonate), dried over Na2SO4, filtered, and the volatiles removed in vacuum to give the titled compound.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 25369-33-9.

Reference:
Patent; MERCK SHARP & DOHME CORP.; WOOD, Harold, B.; ADAMS, Alan, D.; SZEWCZYK, Jason, W.; ZHANG, Yong; YANG, Meng; WO2011/19538; (2011); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

The important role of 7-Chloroindolin-2-one

Statistics shows that 7-Chloroindolin-2-one is playing an increasingly important role. we look forward to future research findings about 25369-33-9.

Application of 25369-33-9, These common heterocyclic compound, 25369-33-9, name is 7-Chloroindolin-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of Scheme 9-1 compound 1 (1 equiv) in acetonitrile (10 vol) at 0 C was added NBS (1.1 equiv). The reaction mixture was stirred at room temperature for 3 h and then quenched with water. The resulting mixture was extracted with ethyl acetate. The organic layer was separated, dried over anhydrous Na2S04, filtered and then concentrated. The residue was purified by column chromatography on silica gel to afford Scheme 9-1 compound 2.

Statistics shows that 7-Chloroindolin-2-one is playing an increasingly important role. we look forward to future research findings about 25369-33-9.

Share a compound : 7-Chloroindolin-2-one

The synthetic route of 25369-33-9 has been constantly updated, and we look forward to future research findings.

Electric Literature of 25369-33-9, These common heterocyclic compound, 25369-33-9, name is 7-Chloroindolin-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Appropriate indolin-2-one or indoline-2-thione (0.3 g) was mixed with acetic anhydride (3 mL) and 4-dimethylaminopyridine (DMAP, 1 mol %). The mixture was heated at 150 C in a round-bottomed flask equipped with an air condenser and CaCl2 guard tube. The reaction time for each reactant is provided in [Table 2] and [Table 3]. After the completion of the reaction excess acetic anhydride was evaporated under reduced pressure. The solid residue obtained in the case of the triacetylated products was suspended in cold methanol and vacuum filtered. The product collected was thoroughly washed with hexane and dried. In the case of mono and diacetylated products the solid residue was purified using flash column chromatography (FCC) (silica gel, hexanes/ethyl acetate).

The synthetic route of 25369-33-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Jha, Mukund; Chou, Ting-Yi; Blunt, Brian; Tetrahedron; vol. 67; 5; (2011); p. 982 – 989;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem