25369-31-7, name is 7-Nitroindolin-2-one, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C8H6N2O3
To a solution of 7-nitroindolin-2-one in methanol (1.0 gm/60 ml), added Pd/C (300 mg, 30 wt %). H2 gas maintained with pressure using hydrogen gas balloon, solution stirred for 4 hours at RT. The catalyst was removed by filtration over celite. The filtrate was concentrated in vacuo to give crude product, which was washed with diethyl ether to afford compound 7-aminoindolin-2-one; YD: 76.77%; mp:248-251 C.; R1 0.6 (CHC13:MeOH:: 9.0:1.0). 1H NMR (DMSO-d6) 200 MHz, delta 3.382 (s, 2H), 4.794 (s, 2H), 6.453- 6.498 (m, 2H), 6.673 (t, J=8.0 Hz, 1H), 9.906 (s, 1H). MS (ESI): mlz 146.8 [M-H]-.
The synthetic route of 25369-31-7 has been constantly updated, and we look forward to future research findings.