Category: 2436-29-5

The chemical industry reduces the impact on the environment during synthesis 2436-29-5, name is 3-(1,3-Dioxoisoindolin-2-yl)propanal, I believe this compound will play a more active role in future production and life. 2436-29-5

Example 27: 2-Fluoro-lambda/-[4-(5-{[3-(4-fluoro-1 -piperidinyl)propyl]amino}-1 ,3,4- oxadiazol-2-yl)phenyl]benzamide; 4-Fluoropiperidine hydrochloride (164 mg, 1.18 mmol) was partitioned between dichloromethane (5 mL) and aqueous sodium hydroxide (2M, 5 mL) and the aqueous phase extracted with further dichloromethane (5 mL). The organic phases were combined and isolated (phase separator). To this solution was added 3-(1 ,3-dioxo-1 ,3-dihydro-2H- isoindol-2-yl)propanal (300 mg, 1.48 mmol) and sodium triacetoxyborohydride (470 mg, 2.22 mmol) and then the reaction was stirred at room temperature overnight. Methanol was added to the reaction mixture which was applied to an SCX cartridge (10 g), washed with methanol and eluted with 2M ammonia in methanol. The solvent was removed in vacuo and the residue was taken up in a solution of methylamine in ethanol (33 %, 2 mL) and the reaction stirred at room temperature overnight. Diethyl ether (7 mL) was then added and the resultant solid removed by filtration. The solvent was removed in vacuo and the crude amine, [3-(4-fluoro-1-piperidinyl)propyl]amine, then taken up in dioxane (3 ml.) and 2-fluoro-lambda/-(4-{5-[(phenylmethyl)sulfonyl]-1 ,3,4-oxadiazol-2-yl}phenyl)benzamide (70 mg, 0.16 mmol) was added. The reaction was heated in the microwave at 100 0C for 15 minutes. The solvent was removed in vacuo and the residue purified by mass directed auto-preparative liquid chromatography. The product was applied to an SCX cartridge, washed with methanol and eluted with 2M ammonia in methanol. The solvent was removed in vacuo to furnish the title product (45 mg) as a white solid. LCMS (ES+ve): [IvHH]+ at m/z 442 (C23H25F2N5O2 requires [M+H]+ at m/z 442.

The chemical industry reduces the impact on the environment during synthesis 2436-29-5. I believe this compound will play a more active role in future production and life.

Reference:
Patent; GLAXO GROUP LIMITED; WO2007/138033; (2007); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

A common compound: 2436-29-5, name is 3-(1,3-Dioxoisoindolin-2-yl)propanal, belongs to indolines-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 2436-29-5

Step 3. 2-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2- dimethyltetrahydrofuro[3,4-d][l,3]dioxol-4- yI)methyl)(methyl)amino)propyl)isoindoline-l,3-dioneTo a stirred solution of 9-((3aR,4R,6R,6aR)-2,2-dimethyl-6- ((methylamino)methyl)tetrahydrofuro[3,4-d][ l ,3]dioxol-4-yl)-9H-purin-6-amine (1.6 g, 5.0 mmol) and 3-(l,3-dioxoisoindolin-2-yl)propanal (2.0 g, 9.8 mmol) in 50 mL DCE was added NaBH(OAc)3 (3.18 g, 15.0 mmol). Then the mixture was stirred at rt overnight. Saturated NaHC03 aqueous solution was added to quench the reaction and the mixture was extracted with DCM (20 mL x 4). The organic phase was concentrated and the residue was purified by SGC (CH3OH : DCM = 1 : 100) to afford the title compound (2.47 g, yield: 94%) as white solid. NMR (500 MHz, MeOD): delta 8.26 (s, 1H), 8.21 (s, 1H), 7.77-7.84 (m, 4H), 6.15 (d, J = 2.5 Hz, 1H), 5.45-5.47 (m, 1H), 5.01-5.03 (m, 1H), 4.34-4.35 (m, 2H), 363-3.69 (m, 2H), 2.70-2.72 (m, 2H), 2.46-2.50 (m, 2H), 2.27 (s, 3H), 1.74-1.78 (m, 2H), 1.37 (s, 3H), 1.24 (s, 3H) ppm. MS (ESI): m/z 508.7 [M+l]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2436-29-5, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; EPIZYME, INC.; CHESWORTH, Richard; KUNTZ, Kevin, Wayne; OLHAVA, Edward, James; PATANE, Michael, A.; WO2012/82436; (2012); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

2436-29-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2436-29-5, name is 3-(1,3-Dioxoisoindolin-2-yl)propanal belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Intermediate 62 : 2-f3-f4-Methyl-3-oxopiperazin-l-vnpropynisoindoline-l,3- dione (0595) To a mixture of 3-(l,3-dioxoisoindolin-2-yl)propanal (515 mg, 2.53 mmol, commercially available from Fluorochem) and Na(OAc)3BH (815.9 mg, 3.85 mmol) in 2-MeTHF (20 mL) was added l-methylpiperazin-2-one (0.420 mL, 3.82 mmol, commercially available from Fluorochem). The mixture was stirred at rt for 4 h 45 min. To the reaction mixture was added aqueous 2M Na2C03 (10 mL) and this mixture stirred at rt for 10 min giving an aqueous phase at approximately pH 10. The layers were separated and the aqueous layer washed with EtOAc (2 x 10 mL). The organic layers were filtered through a cartridge fitted with a hydrophobic frit and the filtrate evaporated in vacuo to give a pale yellow crystalline solid. 2-(3-(4-methyl-3-oxopiperazin-l-yl)propyl)isoindoline-l,3-dione (660.5 mg, 2.192 mmol, 86 % yield). (0596) LCMS (2 min high pH); Rt = 0.74 min, m/z = 302 for [MH]+

The synthetic route of 2436-29-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen John; DEMONT, Emmanuel Hubert; HARRISON, Lee Andrew; LEVERNIER, Etienne; PRESTON, Alexander G; SEAL, Jonathan Thomas; WALL, Ian David; WATSON, Robert J; WOOLVEN, James Michael; (225 pag.)WO2017/174621; (2017); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

2436-29-5, The chemical industry reduces the impact on the environment during synthesis 2436-29-5, name is 3-(1,3-Dioxoisoindolin-2-yl)propanal, I believe this compound will play a more active role in future production and life.

Aldehyde 9 (6.54 g, 32.2 mmol) was dissolved in propan-2-ol (60 ml). 37% aq.formaldehyde (2.64 ml, 35.4 mmol), pyrrolidine (0.27 ml, 3.22 mmol) and propionic acid (0.24 ml, 3.22 mmol) were added and the reaction mixture was stirred at 45 C for 24 h. The reaction mixture was transferred to a separating funnel with sulfate buffer (100 ml) and extracted with EtOAc (3 ¡Á 40 ml). The combined organic phases were washed with NaHCO3 (100 ml), and brine (100 ml), dried (Na2SO4), filtered and concentrated in vacuo to give alkene 12 (3.78 g, 55%) as a white amorphous powderthat required no further purification.

The chemical industry reduces the impact on the environment during synthesis 3-(1,3-Dioxoisoindolin-2-yl)propanal. I believe this compound will play a more active role in future production and life.

Reference:
Article; Domeyer, Svenja; Bjerregaard, Mark; Johansson, Henrik; Pedersen, Daniel Sejer; Beilstein Journal of Organic Chemistry; vol. 13; (2017); p. 644 – 647;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem