Application of 22949-08-2,Some common heterocyclic compound, 22949-08-2, name is 1-(6-Nitroindolin-1-yl)ethanone, molecular formula is C10H10N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step B: l-Acetyl-6-nitroindoline (3.8 g, 18.3 mmol) was suspended in EtOAc (200 mL). Pd/C (650 mg, 10%) was added, and the mixture was hydrogenated at 40-55 p.si.i. for 2 hours. The mixture was then filtered through celite. The filtrate was concentrated, and the residue was triturated with ether to yield l-acetyl-6-aminoindoline (3.18 g, 99%) as an orange solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(6-Nitroindolin-1-yl)ethanone, its application will become more common.
Reference:
Patent; PTC THERAPEUTICS, INC.; HWANG, Peter Seongwoo; TAKASUGI, James; REN, Hongyu; WILDE, Richard Gerald; TURPOFF, Anthony; AREFOLOV, Alexander; KARP, Gary Mitchell; CHEN, Guangming; CAMPBELL, Jeffrey Allen; WO2006/19831; (2006); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem