Category: 22120-50-9

Adding a certain compound to certain chemical reactions, such as: 22120-50-9, name is 2,3-Dimethylindoline, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 22120-50-9, Safety of 2,3-Dimethylindoline

A mixture of 2,3-dimethylindoline (0.10 g, 0.679 mmol) and 2-bromoethanamine hydrobromide(0.153 g, 0.747 mmol) was heated at 122 C for 15 h. The mixture was dissolved in 2M HCl and purifiedby preparative HPLC to give the title compound as a mixture of cis and trans ismoers that was notpurified further (128 mg). LCMS m/z = 191.2 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,3-Dimethylindoline, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Dang, Huong; Feichtinger, Konrad; Frazer, John; Grottick, Andrew J.; Kasem, Michelle; Le, Minh; Lehman, Juerg; Morgan, Michael E.; Ren, Albert; Sage, Carleton R.; Schrader, Thomas O.; Semple, Graeme; Unett, David J.; Whelan, Kevin T.; Wong, Amy; Zhu, Xiuwen; Bioorganic and medicinal chemistry letters; (2020);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 22120-50-9 as follows. 22120-50-9

A mixture of 2,3-dimethylindoline (0.10 g, 0.679 mmol) and 2-bromoethanaminehydrobromide (0.153 g, 0.747 mmol) was heated at 122 C for 15 h. The mixture was dissolved in 2M HC1 and purified by preparative HPLC to give the title compound (128 mg). LCMS m/z = 191.2[M+H]+.

According to the analysis of related databases, 22120-50-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ARENA PHARMACEUTICALS, INC.; SEMPLE, Graeme; BEHAN, Dominic P.; FEICHTINGER, Konrad; GLICKLICH, Alan; GROTTICK, Andrew J.; KAM, Maria Matilde Sanchez; KASEM, Michelle; LEHMANN, Juerg; REN, Albert S.; SCHRADER, Thomas O.; SHANAHAN, William R.; WONG, Amy Siu-Ting; ZHU, Xiuwen; WO2015/66344; (2015); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem