Category: 20780-72-7

Adding a certain compound to certain chemical reactions, such as: 20780-72-7, name is 4-Bromoisatin, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20780-72-7, SDS of cas: 20780-72-7

General procedure: Step 1: To a 250 mL flask equipped with a silicone oil bubbler was added commercially available isatin (7.7 g, 50 mmol) and anhydrous DMF (80 mL). the mixture was cooled down to 0 oC. To this solution was added NaH (1.32 g, 55 mmol), followed by the addition of CH3I in 15 min. Upon completion of the reaction (monitored by TLC), the mixture was diluted with saturated NH4Cl solution and extracted with ethyl acetate. The organic layer was washed with water, dried over Na2SO4, filtered, and concentrated to yield the crude N-methylindoline-2, 3-dione, which was used directly in the next step. Step 2: The N-methylindoline-2, 3-dione (7.58 g, 47 mmol) was refluxed in NH2¡¤NH2-H2O ( 35 percent) for 1h. Then the mixture was cooled to rt. The crude product was extracted with ethyl acetate. The combined organic layer was then dried over Na2SO4, purified by flash chromatography on silica gel (petroleum ether/ethyl acetate = 10:1). 1-Methylindolin-2-one was obtained as a pink solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromoisatin, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhao, Jian-bo; Ren, Xinfeng; Zheng, Bu-quan; Ji, Jian; Qiu, Zi-bin; Li, Ya; Journal of Fluorine Chemistry; vol. 215; (2018); p. 44 – 51;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

20780-72-7, name is 4-Bromoisatin, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 4-Bromoisatin

General procedure: At first, 0.5mmol of aryl aldehyde or isatin was added to a mixture of ketone (cyclohexanone or acetone, 5equiv), 15 or 20molpercent catalyst, 30 or 40molpercent acid, and 2.0mL of solvent at reaction temperature. The reaction mixture was stirred for the indicated time and then purified through flash column chromatography on a silica gel (petroleum ether/ethyl acetate) to afford the pure products.

The synthetic route of 20780-72-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Xu, Biao; Li, Lei; Gou, Shaohua; Tetrahedron Asymmetry; vol. 24; 24; (2013); p. 1556 – 1561;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Reference of 20780-72-7, The chemical industry reduces the impact on the environment during synthesis 20780-72-7, name is 4-Bromoisatin, I believe this compound will play a more active role in future production and life.

1H-4-Bromoindole-2,3-dione (452.06 mg, 2 mmol), (trimethylsilyl)diazomethane (2 mL of 2M in toluene, 4 mmol), and triethylamine (0.56 mL, 4 mmol) were dissolved in ethanol (10 mL) and placed under argon. It was stirred at room temperature for 18 hours. The resulting suspension was filtered and the solid was collected and dried under vacuum to reveal 5-bromo-3-methoxyquinolin- 2(111)-one as a white solid (267 mg, 53percent); m.p. 286 – 288 ¡ãC; ?H NMR (400MHz, DMSO-d6) 611.97 (s, 1H), 7.31 (dd,J 8Hz, ,J2 Hz, 1H), 7.15-7.09 (m, 2H), 7.02 (s, 1H), 3.73 (s, 3H); ?3C NMR (100 MHz, DMSO-d6) 6 156.9, 150.0, 135.0, 128.0, 125.8, 119.7, 118.6, 114.6, 109.0, 55.7

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromoisatin, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; LAVOIE, Edmond J.; BAUMAN, Joseph David; SAGONG, Hye Yeon; ARNOLD, Eddy; PARHI, Ajit; DAS, Kalyan; VIJAYAN, Suyambu Kesava; PATEL, Disha; WO2014/74926; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

These common heterocyclic compound, 20780-72-7, name is 4-Bromoisatin, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8H4BrNO2

General procedure: 4-Bromoisatin (1 eq) was added to a solution of the potassium trifluoroborate salt (1.4 eq), K3P04 (3.6 eq) and degassed solvent. The reaction mixture was degassed and Pd(PPh3)2C12or Pd(dppf)2C12 (0.1 eq) was added. The reaction vessel was sealed and heated by microwave irradiation (Biotage Initiator) for 4 h at 130¡ãC. The reaction mixture was cooled to rt, diluted with EtOAc (-10 mL/mmol substrate) and filtered through Celite?. The organic solution was washed with brine (-10 mL/mmol substrate) and the resulting aqueous layer was further extracted with EtOAc (2 x). The combined organic layers were dried over MgSO4, filtered andconcentrated in vacuo to give the crude product which was purified as specified below.

The synthetic route of 4-Bromoisatin has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ISIS INNOVATION LIMITED; CHRISTOU, Ivy; CROSS, Rebecca Lillian; GIANELLA-BORRADORI, Matteo; GREAVES, David Robert; RUSSELL, Angela Jane; WYNNE, Graham Michael; WO2013/41859; (2013); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20780-72-7, name is 4-Bromoisatin, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H4BrNO2

General procedure: To a solution of compound 3 (1.0 mmol) and substituted isatin (1.0 mmol) in ethanol, 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) (2.0 mmol) was added. The reaction mixture was stirred at room temperature for about 1 h. The solvent was removed and CH2Cl2 was added, the organic phase was washed with water and brine, dried over Na2SO4. After removal of the solvent, the residue was purified by silica gel chromatography using acetone/petroleum ether (1/2) as the eluent to give the corresponding steroidal pyran?oxindole hybrids.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Yu, Bin; Qi, Ping-Ping; Shi, Xiao-Jing; Shan, Li-Hong; Yu, De-Quan; Liu, Hong-Min; Steroids; vol. 88; (2014); p. 44 – 52;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Electric Literature of 20780-72-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20780-72-7 name is 4-Bromoisatin, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A reaction flask with high vacuum valve was charged with 2-amino-N?-arylbenzohydrazides (1.0 mmol), 4-halogenated isatins (1.0 mmol), CuI (10 mg, 0.05 mmol), and Cs2CO3 (650 mg, 2.0 mmol). After being degassed by three freeze-thaw pump cycles, THF (10.0 mL) was injected into the mixture. And then, the reaction mixture was stirred at reflux for 10?16 h before reaching completion, which was monitored by TLC. The solvent was recovered by distillation under reduced pressure, and the residue was purified by chromatography over silica gel to give 3 using ethyl acetate and petroleum ether (1:2) as an eluent.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromoisatin, and friends who are interested can also refer to it.

Reference:
Article; Ma, Yong-Gang; Li, Chao; Yao, Chang-Sheng; Wang, Xiang-Shan; Tetrahedron; vol. 72; 27-28; (2016); p. 3844 – 3850;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

20780-72-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20780-72-7 name is 4-Bromoisatin, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Isatins I (3.0 mmol) was dissolved in anhydrous DMF (15 mL), and the resultant solution was cooled to 0 ¡ãC (ice bath), whereupon sodium hydride (60percent dispersion in mineral oil, 140mg, 3.5 mmol, 1.17 equiv) was added in one portion and stirred for 5 minutes. Iodomethane (497 mg, 3.5 mmol, 1.17 equiv) or benzyl bromide (564.3 mg, 3.3 mmol, 1.1 equiv) was added and the reaction was stirred at 0 ¡ãC for 30min. The reaction was monitored by TLC until I was fully consumed. The reaction mixture was then poured into saturated aqueous NH4Cl and extracted with ethyl acetate. The combined organic portions were washed with water and brine, dried (MgSO4), filtered, and concentrated to give N-methyl isatins and N-benzyl isatins II (90percent-100percent yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromoisatin, and friends who are interested can also refer to it.

Reference:
Article; Liang, Jin-Yan; Wang, Hui; Yang, Yan-Li; Shen, Shou-Jie; Chen, Jian-Xin; Tetrahedron Letters; vol. 58; 27; (2017); p. 2636 – 2639;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

20780-72-7, Name is 4-Bromoisatin, 20780-72-7, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

General procedure: A solution of 2-nitrobenzamides 1 or bis(2-nitrobenzamides) 4 (1 mmol), isatins 2 or acenaphthylene-1,2-diones 6 (1 mmol), and SnCl2*2H2O (4 mmol) in EtOH (5 mL) was stirred at reflux for 3-5 h. After this period, the TLC analysis of the mixture showed the reaction to be completed. The mixture was quenched with 3percent HCl (10 mL) and filtered to yield a crude product, which was purified by recrystallization from 95percent ethanol and DMF.

Statistics shows that 4-Bromoisatin is playing an increasingly important role. we look forward to future research findings about 20780-72-7.

Reference:
Article; Hu, Yu; Wang, Man-Man; Chen, Hui; Shi, Da-Qing; Tetrahedron; vol. 67; 48; (2011); p. 9342 – 9346;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem