Category: 2058-74-4

Adding a certain compound to certain chemical reactions, such as: 2058-74-4, name is 1-Methylisatin, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2058-74-4, Quality Control of 1-Methylisatin

General procedure: Sulfonated-b-cyclodextrin (b-CD-SO3H) (0.1 mmol) was dissolved in water(2 mL) at room temperature by stirring to get the clear solution. Then thereaction was shifted to reflux with addition of isatin (1 mmol) and indole(2 mmol) with constant stirring. The progress of the reaction was monitored byTLC. After completion of reaction, it was cooled to room temperature andfiltered, to get the solid. The crude product was recrystallized from aqueousethanol (60:40) giving pure 3,3-di(indolyl)indolin-2-ones.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methylisatin, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Tayade, Yogesh A.; Patil, Dipak R.; Wagh, Yogesh B.; Jangle, Asha D.; Dalal, Dipak S.; Tetrahedron Letters; vol. 56; 5; (2015); p. 666 – 673;,
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Application of 2058-74-4, These common heterocyclic compound, 2058-74-4, name is 1-Methylisatin, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a mixture of isatin (1 equiv.) and indole (1 or 2 equiv.) in water (3 mL), CuWO4 (10 mol%) was added and the mixture was stirred at room temperature for 2 h or heated at 60 C for 2 h. After completion of the reaction (monitoring by TLC), the mixture was cooled (in the case of bis-indolyl-2-oxindoles) and extracted with EtOAc (2¡Á10 mL). The organic layers were washed with brine, dried using sodium sulfate. Evaporation of the solvent gave the desired product which was purified by silica gel column chromatography. Elution of the column with PE:EtOAc gave the desired products (5 or 6).

The synthetic route of 2058-74-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Paplal, Banoth; Sathish, Kota; Nagaraju, Sakkani; Kashinath, Dhurke; Catalysis Communications; vol. 135; (2020);,
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These common heterocyclic compound, 2058-74-4, name is 1-Methylisatin, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 1-Methylisatin

General procedure: A solution of N-methylisatin (322 mg, 2.0 mmol), phenylacetylene (306 mg, 3.0 mmol), CuI (76 mg, 0.4 mmol), and Cs2CO3 (978 mg, 3.0 mmol) in CH3CN (4.0 mL) was stirred at room temperature for 18 h. After aqueous extractive workup and column chromatographic purification process (CH2Cl2/EtOAc, 15:1) 1a was obtained as a pale yellow solid, 347 mg (66%). Other compounds were prepared similarly, and compounds 1a-1i are all known compounds.1

The synthetic route of 1-Methylisatin has been constantly updated, and we look forward to future research findings.

Reference:
Article; Roh, Hwa Jung; Kim, Gieun; Cho, Sung; Ryu, Ji Yeon; Lee, Junseong; Kim, Jae Nyoung; Tetrahedron Letters; vol. 59; 15; (2018); p. 1484 – 1488;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

2058-74-4, These common heterocyclic compound, 2058-74-4, name is 1-Methylisatin, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under an inert gas atmosphere, add a stir bar, 0.75 mmol of 1-methylisatin, 0.05 mmol of DBU, and 2 mL of acetonitrile to the autoclave, and then fill the autoclave with carbonyl sulfide gas of about 0.8MPa. After stirring for 24 hours at , the autoclave was opened, the reaction solution in the autoclave was dissolved in 2 ml of dichloromethane and transferred to a 50 ml round-bottomed single-neck flask, with (3¡Á2 ml) dichloromethane The autoclave was rinsed, and then the solvent was removed in vacuo to obtain a crude product.The crude product was separated and purified by column chromatography (eluent: dichloromethane).The yield was 91%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2058-74-4.

Reference:
Patent; Dalian University of Technology; Zhou Hui; Chen Wei; Lv Xiaobing; (10 pag.)CN111233741; (2020); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2058-74-4, name is 1-Methylisatin, This compound has unique chemical properties. The synthetic route is as follows., 2058-74-4

General procedure: To a mixture of indole-2,3-dione 1a (1.0 mmol) and o-aminothiophenol 2 (1.0 mmol) in distilled water (5.0 mL), was added TBAB (0.0483 g, 15 mol %). This reaction mixture was allowed to stir magnetically at 60 C. Progress of the reaction was monitored by TLC (Pet. ether-ethyl acetate = 4:1) and visualization was accomplished in an iodine chamber. After completion of the reaction, the solid obtained was collected by filtration and washed with warm water. The crude product, so obtained was purified by crystallization with ethanol to afford pure product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Jain, Renuka; Sharma, Kanti; Kumar, Deepak; Tetrahedron Letters; vol. 53; 46; (2012); p. 6236 – 6240,5;,
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2058-74-4, Adding a certain compound to certain chemical reactions, such as: 2058-74-4, name is 1-Methylisatin, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2058-74-4.

General procedure: The SiO2/g-C3N4 nanocomposite (25 mg) was dispersed in water (3 ml) for 30 min. Indole (2.0 mmol), and isatin (1.0 mmol) were added to the mixture which was stirred for the appropriate time. The progress of the reaction was monitored by thin layer chromatography. After the completion of the reaction, the crude product was extracted with ethyl acetate and dried over anhydrous Na2SO4. Then, the crude product was recrystallized in hot ethanol. The SiO2/g-C3N4 nanocatalyst was recovered from the aqueous layer by centrifuging, washed with EtOH, dried and reused for the next run.

According to the analysis of related databases, 2058-74-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Allahresani, Ali; Nasseri, Mohammad Ali; Nakhaei, Alireza; Research on Chemical Intermediates; vol. 43; 11; (2017); p. 6367 – 6378;,
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2058-74-4,Some common heterocyclic compound, 2058-74-4, name is 1-Methylisatin, molecular formula is C9H7NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of N-methylisatin (322 mg, 2.0 mmol), phenylacethylene (306 mg, 3.0 mmol), CuI (76 mg, 0.4 mmol), and Cs2CO3 (978 mg, 3.0 mmol) in CH3CN (4.0 mL) was stirred at room temperature for 18 h. After aqueous extractive workup and column chromatographic purification process (CH2Cl2/EtOAc, 15:1) 1a was obtained as a pale yellow soild, 347 mg (66%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methylisatin, its application will become more common.

Reference:
Article; Roh, Hwa Jung; Kim, Su Yeon; Min, Beom Kyu; Kim, Jae Nyoung; Tetrahedron Letters; vol. 58; 1; (2017); p. 21 – 24;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

2058-74-4, A common heterocyclic compound, 2058-74-4, name is 1-Methylisatin, molecular formula is C9H7NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In the test tube (0.5 mmol) isatin or acenaphthoquinone with 0.5mmol active methylene and 0.5 mmol 1,3-dicarbonyl compounds/4Hcumarin/alpha naphtol and 0.5 mL urea:ChCl were added. The reaction mixture was stirred and heated to 80 C. The reaction completion was monitored by TLC. After reaction completion about 5 mL water was added to reaction mixture in the cases that the solid was obtained and the solid was filtered, and in the cases that a viscose liquid was obtained after water addition the ethyl acetate was added to extract the product and the organic layer was removed under vacuum. The products were recrystallized from ethanol to give pure corresponding compounds

The synthetic route of 1-Methylisatin has been constantly updated, and we look forward to future research findings.

Reference:
Article; Azizi, Najmedin; Dezfooli, Sahar; Mahmoudi Hashemi, Mohammad; Journal of Molecular Liquids; vol. 194; (2014); p. 62 – 67;,
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2058-74-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2058-74-4 as follows.

A solution of N-methylisatin (322 mg, 2.0 mmol), indole (258 mg, 2.2 mmol), and K 2 CO 3 (138 mg, 1.0 mmol) in aqueous DMF (H 2 O/DMF, 2:1, 5.0 mL) was heated to 50 o C for 3 h. After aqueous extractive workup and column chromatographic purification process (n-hexane/EtOAc, 1:1), 3-hydroxy-3-(1H-indol-3-yl)-1-methylindolin-2-one was obtained as a white solid, 340 mg (61%). A solution of 3-hydroxy-3-(1H-indol-3-yl)-1-methylindolin-2-one (278 mg, 1.0 mmol), 5-methyl-1H-indole (131 mg, 1.0 mmol), and p-TsOH . H 2 O (19 mg, 0.1 mmol) in CH 2 Cl 2 (2.0 mL) was stirred at room temperature for 1 h. After aqueous extractive workup and column chromatographic purification process (n-hexane/EtOAc, 2:1), 5,1′-dimethyl-1H,1’H,1”H-[3,3′;3′,3”]terindol-2′-one was obtained as a white solid, 348 mg (89%). To a stirred solution of 5,1′-dimethyl-1H,1’H,1”H-[3,3′;3′,3”]terindol-2′-one (196 mg, 0.5 mmol) in DMF (3.0 mL) was added t-BuOK (125 mg, 1.1 mmol) and iodomethane (158 mg, 1.1 mmol) successively at 0 o C. The reaction mixture was stirred at room temperature for 3 h. After aqueous extractive workup and column chromatographic purification process (n-hexane/EtOAc, 3:1), compound 1g was obtained as a white solid, 156 mg (74%). Compound 1h was synthesized similarly, and the spectroscopic data of unknown compounds 1g and 1h are as follows. Compound 1g: 74%; pale yellow solid, mp 202-204 o C; IR (KBr) 1716, 1490, 1469, 1370, 1340 cm -1 ; 1 H NMR (CDCl 3 , 500 MHz) 1gNOMeNNMeMeMe6 delta 2.31 (s, 3H), 3.35 (s, 3H), 3.66 (s, 3H), 3.69 (s, 3H), 6.79 (s, 1H), 6.86 (s, 1H), 6.93 (t, J = 7.5 Hz, 1H), 6.95-7.05 (m, 3H), 7.12 (s, 1H), 7.13-7.19 (m, 2H), 7.21 (d, J = 8.1 Hz, 1H), 7.27 (d, J = 8.1 Hz, 1H), 7.33 (t, J = 7.7 Hz, 1H), 7.43 (d, J = 7.2 Hz, 1H); 13 C NMR (CDCl 3 , 125 MHz) delta 21.6, 26.6, 32.75, 32.77, 52.7, 108.0, 108.9, 109.2, 113.0, 113.7, 118.9, 121.12, 121.13, 121.4, 122.6, 123.2, 125.3, 126.3, 126.5, 127.9, 128.0, 128.8, 128.9, 134.2, 136.2, 137.7, 142.9, 177.8; MALDI-TOF m/z 420 [M+H] + .

According to the analysis of related databases, 2058-74-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Seo, Da Young; Kim, Gieun; Jo, Hwi Yul; Kim, Jae Nyoung; Bulletin of the Korean Chemical Society; vol. 39; 4; (2018); p. 587 – 590;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2058-74-4, name is 1-Methylisatin belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. 2058-74-4

General procedure: A solution of N-methylisatin (81 mg, 0.5 mmol), phenylacethylene (77 mg, 0.75 mmol), CuI (19 mg, 0.1 mmol), and Cs2CO3 (245 mg, 0.75 mmol) in CH3CN (1.0 mL) was stirred at room temperature for 18 h. After aqueous extractive work up and column chromatographic purification process (CH2Cl2/EtOAc, 15:1) 1a was obtained as a pale yellow soild, 81 mg (61%). Other compounds were prepared similarly, and the spectroscopic data of unknown compounds 1b, 1d, and 1e are as follows.

The synthetic route of 2058-74-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Roh, Hwa Jung; Lim, Jin Woo; Ryu, Ji Yeon; Lee, Junseong; Kim, Jae Nyoung; Tetrahedron Letters; vol. 57; 38; (2016); p. 4280 – 4283;,
Indoline – Wikipedia,
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