Category: 2058-72-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, A new synthetic method of this compound is introduced below., HPLC of Formula: C9H6BrNO2

General procedure: A mixture of isatin (0.14 g, 1mmol), 5,5-dimethylcyclohexanedione (0.14 g, 1 mmol), 2-hydroxy-4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-one (0.22 g, 1 mmol) and H3PW12O40 (0.06 g, 3 mol%) in dry acetonitrile (5 ml) was refluxed. The reaction progress was monitored by thin-layer chromatography (eluent: ethylacetate/hexane (2:1)). After completion of the reaction, the reaction mixture was cooled to room temperature. Then, the precipitated product was filtered and washed with acetonitrile (10ml). The obtained crude mass was purified by column chromatography over silica gel using ethylacetate/hexane (1:1) as eluent to give the desired product.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Jannati, Saeideh; Esmaeili, Abbas Ali; Tetrahedron; vol. 74; 24; (2018); p. 2967 – 2972;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

These common heterocyclic compound, 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2058-72-2

General procedure: A mixture of corresponding compound 1(0.5 mmol), isatin 3 (0.5 mmol), and sarcosine (0.5 mmol) in acetonitrile (40 mL) (for 1a-c) or in amixture of acetonitrile (30 mL) and chloroform (10 ml) (for 1d-f) was refluxed with stirring for 36 or 72 h for starting compounds 1a-c and 1d-f, respectively. Then the reaction mixture was cooled to room temperature, the precipitate of compounds 4a-e,j,o was filtered off and washed with acetonitrile and water. The reaction mixture of compounds 4f-i,k-n,p-t was concentrated on a rotary evaporator to half of an original volume. After cooling, the precipitate was filtered off and washed with water. Recrystallization from acetonitrile or methanol (4n) gave dispirocompounds 4a-t.

The synthetic route of 5-Bromo-1-methylindoline-2,3-dione has been constantly updated, and we look forward to future research findings.

Reference:
Article; Izmest’ev, Alexei N.; Gazieva, Galina A.; Sigay, Natalya V.; Serkov, Sergei A.; Karnoukhova, Valentina A.; Kachala, Vadim V.; Shashkov, Alexander S.; Zanin, Igor E.; Kravchenko, Angelina N.; Makhova, Nina N.; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 2240 – 2249;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Electric Literature of 2058-72-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: 30 mg of SiO2_g-C3N4 nanocomposite was dispersed in aqueous media (3 ml) for 30 min and dimedone or 4-hydroxycoumarin (1 mmol), malononitrile (1 mmol) and isatin (1.0 mmol) were added to the mixture. Then, the mixture was stirred at reflux conditions for an appropriate time, while the reaction progress was monitored by thin layer chromatography (TLC). After the reaction was completed, ethyl acetate was employed for the extraction of crude product and the products were dried over anhydrous Na2SO4. The solvent was evaporated followed by recrystallizing of the crude product in hot ethanol, and pure products were identified by IR, 1H and 13C NMR spectral data. The SiO2_g-C3N4 nanocatalyst was washed with EtOH, dried and reused for the next run.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1-methylindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Allahresani, Ali; Taheri, Bahare; Nasseri, Mohammad Ali; Research on Chemical Intermediates; vol. 44; 2; (2018); p. 1173 – 1188;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 5-Bromo-1-methylindoline-2,3-dione

General procedure: N-substituted isatin (3a-g) (0.9 mmol) and tryptamine (4) (1 mmol) in EtOH (5mL) in the presence of (0.2 mL) glacial acetic acid and 4 A molecular sieve were stirred at RT for 24 hours. The precipitate was removed by filtration and the filtrate was concentrated and purified by column chromatography (silica gel, hexane/EtOAc (2:1) to give compounds 5a-g.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2058-72-2.

Reference:
Article; Phutdhawong, Weerachai; Rattanopas, Sopita; Sirirak, Jitnapa; Taechowisan, Thongchai; Phutdhawong, Waya S.; Oriental Journal of Chemistry; vol. 35; 2; (2019); p. 723 – 731;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Reference of 2058-72-2, A common heterocyclic compound, 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, molecular formula is C9H6BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of ligand 1(11mol %) in ethanol (2 ml) was added coppersalt (10 % mol), After 5 hours the color of the solution changed from blue-green to purple. Then,dipolarophile (0.20 mmol) has been added andstirred about 30 min. Next, a mixture of isatin derivatives (0.20 mmol) and (S)-proline (0.21 mmol), in 3 ml ethanol/dichloromethane (5/1) was added to reaction mixture.After completion of the reaction (monitored by TLC), reaction was diluted withdiethyl ether and filtered through a pad of silica gel. The organic layer wasconcentrated in vacuum to furnish the products, which were recrystallized fromethanol.

The synthetic route of 2058-72-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Salahi, Farbod; Taghizadeh, Mohammad Javad; Arvinnezhad, Hamid; Moemeni, Mehdi; Jadidi, Khosrow; Notash, Behrouz; Tetrahedron Letters; vol. 55; 9; (2014); p. 1515 – 1518;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Safety of 5-Bromo-1-methylindoline-2,3-dione

General procedure: A mixture of an N-substituted isatin (1.0 mmol), benzoyl cyanid (0.145 g, 1.1 mmol), and MS 4A (200 mg) in dry acetonitrile (2 mL) was stirred at room temperature for the indicated time (Table 2). The progress of the reaction was monitored by TLC. After completion of the reaction, the MS 4A was recovered by simple filtration, thoroughly washed with dry acetonitrile. Then the filtrate was evaporated to dryness in a rotary evaporator under reduced pressure and the residue was crystallized from a mixture of CH2Cl2 and petroleum ether, which yielded the pure products.

The synthetic route of 2058-72-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Esmaeili, Abbas Ali; Ghalandarabad, Saeid Amini; Zangouei, Mahdieh; Tetrahedron Letters; vol. 53; 42; (2012); p. 5605 – 5607;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. name: 5-Bromo-1-methylindoline-2,3-dione

General procedure: To a boiling slurry of 1 mmol of imidazothiazolotriazine hydrobromide 1a and 1b and 1 mmol of an appropriate isatin 2 in 15 mL of methanol, 0.108 mL of 40% water solution of KOH was added. The reaction mixture was stirred for 2 h. The precipitate separated on cooling the reaction mixture was filtered off, if necessary recrystallized from methanol, and dried.

The synthetic route of 2058-72-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Izmest?ev; Gazieva; Kulikov; Anikina; Kolotyrkina; Kravchenko; Russian Journal of Organic Chemistry; vol. 53; 5; (2017); p. 753 – 763; Zh. Org. Khim.; vol. 53; 5; (2017); p. 741 – 750,10;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, A new synthetic method of this compound is introduced below., SDS of cas: 2058-72-2

To a sol. of 5-bromo-1-methyl-1 H-indole- 2,3-dione (3.60 g, 15.0 mmol) in THF (100 mL) are added sequentially at rt trifluoromethyl)trimethylsilane (4.43 mL, 30.0 mmol) and CsF (91.1 mg, 0.60 mmol). The resulting sol. is stirred at rt overnight. The mixture is quenched with cold water (100 mL). The mixture is extracted with EtOAc (3 x 100 mL). The comb. org. layers are washed with brine (100 mL), dried over MgS04, filtered, and the solvents are removed under reduced pressure. Purification of the residue by automated FC (Combiflash, column 80 g, flow 60 mL/min, EtOAc / heptane 0:100 ? 20:80) yields the tri methyl si lyl -protected product. To a sol. of this isolated compound in MeOH (50 mL) is added aq. 2M HCI (40 mL). The resulting sol. is stirred at rt for 2 h. The reaction is diluted with CH2CI2 (100 mL). The layers are separated and the aq. phase is extracted with CH2CI2 (2x 50 mL). The comb. org. layers are washed with brine (1 x 50 mL), dried over MgS04, filtered, and the solvents are removed under reduced pressure to yield the crude title product. LC-MS: tR = 0.79 min (conditions 3).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; SIEGRIST, Romain; HEIDMANN, Bibia; STAMM, Simon; GATFIELD, John; BEZENCON, Olivier; WO2015/186056; (2015); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Related Products of 2058-72-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2058-72-2 as follows.

General procedure: Dialkyl acetylenedicarboxylate 2 (1 mmol) was added to a magnetically stirred 5 mL flat bottom flask containing hydrazine hydrate (1 mmol) and H2O (2 mL) at room temperature. After 10 min, isatin 1(1 mmol) malononitrile (1 mmol) and NaCl (20 mol %) were added and the reaction heated at 50 C for 10 min. After completion of the reaction (monitoring by TLC), the reaction mixture was filtered and the precipitate washed with water and then ether to afford the pure products 3a-h. Methyl 6?-amino-5-bromo-5?-cyano-1-methyl-2-oxo-1?H-spiro-[indoline-3,4?-pyrano[2,3-c]pyrazole]-3?-carboxylate (3g): Yellow powder; yield: 0.25 (80%); m.p. 275-276 C; IR (KBr): 3432, 3307, 3173 (NH2and 2NH), 2200 (C?N), 1720 (CO2Me), 1698 (NCO), 1638, 1602, 1487 (Ar), 1190 (C-O) cm-1; 1H NMR: delta3.35 (3H, s, NCH3), 3.48 (3H, s, OCH3), 7.09 (1H, d, 3JHH= 7.6 Hz, CH6of Ar), 7.31 (1H, s, CH4of Ar), 7.44 (2H, s, NH2), 7.50 (1H, d, 3JHH= 7.2 Hz, CH7of Ar), 14.05 (1H, s, NH) ; 13C NMR: delta26.5 (NCH3), 47.0 (Cspiro), 52.0 (OCH3), 55.5 (C-CN), 99.8 (C3?), 110.2 (CH7), 114.3 (C-Br), 117.8 (CN), 126.4 (CH4), 128.3 (C3a), 131.3 (CH6), 135.2 (C-CO2Me), 142.9 (C7a), 155.9 (OCN), 157.6 (CO2Me), 161.2 (C-NH2), 175.4 (C=O of isatin); MS (EI, 70 eV): m/z (%) = 430 [M+], 403, 287, 142, 101, 83, 59. Anal. calcd for C17H12BrN5O4(430.21): C, 47.46; H, 2.81; N, 16.28; found: C, 47.39; H, 2.74; N, 16.37%.

According to the analysis of related databases, 2058-72-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Alizadeh, Abdolali; Moafi, Leila; Journal of Chemical Research; vol. 39; 8; (2015); p. 464 – 466;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, A new synthetic method of this compound is introduced below., Computed Properties of C9H6BrNO2

General procedure: 30 mg of SiO2_g-C3N4 nanocomposite was dispersed in aqueous media (3 ml) for 30 min and dimedone or 4-hydroxycoumarin (1 mmol), malononitrile (1 mmol) and isatin (1.0 mmol) were added to the mixture. Then, the mixture was stirred at reflux conditions for an appropriate time, while the reaction progress was monitored by thin layer chromatography (TLC). After the reaction was completed, ethyl acetate was employed for the extraction of crude product and the products were dried over anhydrous Na2SO4. The solvent was evaporated followed by recrystallizing of the crude product in hot ethanol, and pure products were identified by IR, 1H and 13C NMR spectral data. The SiO2_g-C3N4 nanocatalyst was washed with EtOH, dried and reused for the next run.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Allahresani, Ali; Taheri, Bahare; Nasseri, Mohammad Ali; Research on Chemical Intermediates; vol. 44; 2; (2018); p. 1173 – 1188;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem