Category: 2058-72-2

2058-72-2, The chemical industry reduces the impact on the environment during synthesis 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, I believe this compound will play a more active role in future production and life.

General procedure: A mixture of N-methylisatin 1a (161 mg, 1 mmol, 1 equiv), phenylacetylene 2a (0.12 mL, 1 mmol, 1.2 equiv), 1-aminoanthraquinone (0.266 g, 1 mmol, 1.2 equiv) 3a, cuprous chloride (9.9 mg, 10 mol %), and copper(II) triflate (36.1 mg, 10 mol %) in dry toluene (4 mL) was refluxed at 120 C for 24 h under nitrogen atmosphere. The progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was cooled to room temperature, filtered through a pad of neutral alumina using ethyl acetate as a solvent. The solvent was evaporated in vacuo and the residue was chromatographed on neutral alumina using gradient elution of hexane/ethyl acetate as solvent to yield compounds 4a as pink powder, 183 mg, 39% yield and 5a as violet powder, 197 mg, 42% yield.

The chemical industry reduces the impact on the environment during synthesis 5-Bromo-1-methylindoline-2,3-dione. I believe this compound will play a more active role in future production and life.

Reference:
Article; Periyaraja, Somasundharam; Shanmugam, Ponnusamy; Mandal, Asit Baran; Senthil Kumar, Thiyagarajan; Ramamurthy, Perumal; Tetrahedron; vol. 69; 14; (2013); p. 2891 – 2899;,
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2058-72-2, Adding some certain compound to certain chemical reactions, such as: 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2058-72-2.

To a stirred mixture of isocyanoacetate 1 (0.12 mmol),2-MeOC6H4CO2H (10 mol%), 4a (10 mol%), and AgPF6 (11 mol%)in THF (0.5 mL) was added isatin 2 (0.1 mmol) and THF (0.5 mL)at 0 C. The reaction was then allowed to proceed at 0 C for 4-6h. Upon completion, the reaction mixture was purified by flashchromatography on silica gel to afford the desired product.Analytical data of some typical compounds:

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2058-72-2.

Reference:
Article; Lu, Yan; Wang, Min; Zhao, Xiaohu; Liu, Xiaohua; Lin, Lili; Feng, Xiaoming; Synlett; vol. 26; 11; (2015); p. 1545 – 1548;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

2058-72-2, Adding some certain compound to certain chemical reactions, such as: 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2058-72-2.

General procedure: A mixture of isatin(1.0 mmol), alpha-amino acid (1.0 mmol) and acrylamide (1.0 mmol) in 4.0 mL aqueous methanol (1:3) was heated in an oil bath to reflux temperature for 40 min to 7 hours. The resulting precipitates were collected by filtration and washed with cold methanol to give the analyticallypure products 4.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2058-72-2.

Reference:
Article; Pavlovskaya, Tatyana L.; Yaremenko, Fedor G.; Lipson, Victoria V.; Shishkina, Svetlana V.; Shishkin, Oleg V.; Musatov, Vladimir I.; Karpenko, Alexander S.; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 117 – 126;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. 2058-72-2

General procedure: A mixture of substituted isatin 4a-v (1 mmol), sarcosine 5 (1 mmol) and 3-(1H-indol-3-yl)-3-oxo-2-(2-oxoindolin-3-ylidene)propanenitrile 6 (1 mmol) were refluxed in ethanol (5 mL). After completion of the reaction as evidenced by TLC analysis, the reaction mixture was poured into ice-water, the resulting solid was filtered off and purified by column chromatography using ethyl acetate/petroleum ether (6:4) as an eluent to afford pure spirooxindoles 7a-v.

The synthetic route of 2058-72-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Arun; Bhaskar; Balachandran; Ignacimuthu; Perumal; Bioorganic and Medicinal Chemistry Letters; vol. 23; 6; (2013); p. 1839 – 1845;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. 2058-72-2

General procedure: Triethanolamine (20 mol %) wasadded to a solution of 1,2-benzoxathiin-4(3H)-one 2,2-dioxide(1) (0.198 g, 0.001 mol), malononitrile (2) (0.066 g,0.001 mol), and appropriate isatin 3a-n (0.001 mol) in EtOH (5-10 ml). The mixture was refluxed for 1 h. The obtained precipitates of compounds 4a-n were filtered off,washed with EtOH, dried in air, and recrystallized from EtOH-DMF, 1:1.

The synthetic route of 2058-72-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Grygoriv, Galina V.; Lega, Dmitry A.; Zaprutko, Lucjusz; Gzella, Andrzej K.; Wieczorek-Dziurla, Ewa; Chernykh, Valentine P.; Shemchuk, Leonid A.; Chemistry of Heterocyclic Compounds; vol. 55; 3; (2019); p. 254 – 260;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

These common heterocyclic compound, 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 2058-72-2

General procedure: A mixture of isatin (1) (2.0 mmol), L-proline (2) (2.0 mmol) and acrylonitrile/methyl acrylate (3/5) (2.0 mmol) in 10 mL of water was heated in an oil bath at 80 C for 3 to 6 hours. Initially reaction mixture appeared to be homogeneous but with the progress of reaction the solid precipitated out. TLC indicated the consumption of L-proline and acrylonitrile while isatin was remaining in small portion. The reaction mixture was extracted many times with ethylacetate (EA). The combine organic layer was dried over anhydrous Na2SO4 and evaporated on rotary evaporator to provide yellow colour solid. The solid was purified by silica gel column chromatography using EA:hexane (4:6) as an eluent to provide desired product 4 and 6 as white solid. The yield mentioned in the analytical data has been calculated after recovering the unreacted isatin (amount mentioned in characterization data).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2058-72-2.

Reference:
Article; Tiwari, Keshri Nath; Pandurang, Taur Prakash; Pant, Suyash; Kumar, Rahul; Tetrahedron Letters; vol. 57; 21; (2016); p. 2286 – 2289;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Adding some certain compound to certain chemical reactions, such as: 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2058-72-2. 2058-72-2

General procedure: A mixture of isatin (1a) (0.3 gm, 2.0 mmol) and enaminone (2a) (0.333 gm,2.4 mmol) in 10 mL of water was heated in an oil bath at 80C for 9 hours. Initially,orange-colored reaction mixture appeared to be homogeneous but with the progress ofthe reaction, yellow color solid precipitated out. After the TLC indicated the completeconsumption of starting materials, the precipitated solid was filtered off. The solid wasthen dried under vacuum and purified by silica gel column chromatography by using EA: hexane (8:2) as an eluent to provide the desired product.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5-Bromo-1-methylindoline-2,3-dione.

Reference:
Article; Tiwari, Keshri Nath; Thakar, Snehal Rajendra; Kumar, Vaneet; Prabhakaran; Synthetic Communications; vol. 48; 23; (2018); p. 2965 – 2972;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

2058-72-2, A common compound: 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, belongs to indolines-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

General procedure: A solution of isatin (0.035 mmol, 1.2 equiv), tryptamine (0.03 mmol, 1.0 equiv) and (R)-3,3′-bis(9-anthracenyl)-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate (0.006 mmol, 0.2 equiv) was prepared in dry CH2Cl2 (0.06 M) at 25 C in an oven-dried and Ar-purged 4 mL vial fitted with a magnetic stir bar. The reaction was stirred until it was complete as judged by TLC (80% EtOAc/hexanes). The reaction was then concentrated and loaded onto a flash silica gel column (gradient of EtOAc/hexanes ending in 80% EtOAc/hexanes) to afford the spiroindolone product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1-methylindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Badillo, Joseph J.; Silva-Garcia, Abel; Shupe, Benjamin H.; Fettinger, James C.; Franz, Annaliese K.; Tetrahedron Letters; vol. 52; 43; (2011); p. 5550 – 5553;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

2058-72-2, The chemical industry reduces the impact on the environment during synthesis 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, I believe this compound will play a more active role in future production and life.

General procedure: To a flame-dried screw-capped test tube equipped with a magnetic stir bar was added 1, 4, 7, 10, 13, 16-hexaoxacyclooctadecane (0.396 g, 1.5 mmol), KF (0.087 g, 1.5 mmol) and 1- methylindoline-2,3-dione 3 (0.50 mmol). Then the screw-capped tube was evacuated and backfilled with argon. The mixture was dissolved in THF (2.0 mL) under argon atmosphere. The resultant reaction mixture was kept stirring at 30 C for 5 min. To the stirring solution was then added isoquinoline 1 (0.50 mmol) and the aryne precursor 2 (0.75 mmol). Then the reaction mixture was placed in preheated oil bath at 70 C. When TLC control showed the completion of the reaction (typically after 24 h), the reaction mixture cooled to room temperature and the solvent was evaporated and the crude residue was subsequently purified by flash column chromatography on silica gel to afford the corresponding spirooxazino isoquinoline derivatives (4) as an inseparable mixture of diastereomers in moderate to good yields. The dr was determined by 1H MR analysis of crude reaction mixture

The chemical industry reduces the impact on the environment during synthesis 5-Bromo-1-methylindoline-2,3-dione. I believe this compound will play a more active role in future production and life.

Reference:
Patent; COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH; THANKAPPAN, Biju Akkattu; BHUNIA, Anup; ROY, Tony; WO2014/184808; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

2058-72-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, A new synthetic method of this compound is introduced below.

General procedure: The general synthetic approach involved condensation of an equimolar mixture of corresponding substituted indole-2,3-dione (0.01 mol) and substituted pyrazole (0.01 mol) in absolute ethanol in the presence of 2,3-drops of glacial acetic acid for 3-4 h. On cooling, flakes separated out which were filtered and recrystallized from hot ethanol to give shining bright needles of Schiff base.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Chinchole; Wankhede; Asian Journal of Chemistry; vol. 30; 10; (2018); p. 2220 – 2224;,
Indoline – Wikipedia,
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