Application of 162100-55-2, These common heterocyclic compound, 162100-55-2, name is 5-(Trifluoromethyl)indoline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 2 1-[2-(Pyridin-2-ylmethyloxy)pyridin-5-ylcarbamoyl]-5trifluoromethylindoline E2) Phenyl N-[2-(pyridin-2-ylmethyloxy)pyridin-5-yl] carbamate (D3, 0.20 g, 0.62 mmol) in dry dimethylformamide (10 ml) was treated with 5-trifluoromethylindoline (D6, 0.12 g, 0.62 mmol) and heated at 100 C. for 1 hour. After cooling to ambient temperature, the solvent was removed in vacuo. The residue was dissolved in dichloromethane, washed with 10% aqueous sodium hydroxide solution, dried (Na2SO4) and evaporated in vacuo. The resulting oil was chromatographed on silica gel eluding with 2% methanol/dichloromethane and triturated with diethyl ether to afford the title compound (0.08 g, 31%) as an off-white solid. 1H NMR (250 MHz; d6DMSO) delta (ppm): 3.28 (2H, t, J=10), 4.19 (2H, t, J=10), 5.40 (2H, s), 6.94 (1H, d, J=10), 7.28-7.37 (1H, m), 7.40-7.58 (3H, m), 7.82 (1H, dt, J=2,7), 7.90 (1H, dd, 3=2,7), 8.00 (1H, d, J=10), 8.26 (1H, d, J=3), 8.56 (1H, d, J=7), 8.75 (1H, s).
The synthetic route of 162100-55-2 has been constantly updated, and we look forward to future research findings.