Category: 161596-47-0

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 161596-47-0, Name is (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, SMILES is O=C1N(C[C@@H]2OC2)C(C3=C1C=CC=C3)=O, belongs to indolines-derivatives compound. In a document, author is Song Chunlan, introduce the new discover, Application In Synthesis of (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione.

Electrooxidation Enables Selective Dehydrogenative [4+2] Annulation between Indole Derivatives

Dearomative annulation of indoles has emerged as a powerful tool for the preparation of polycyclic indoline-based alkaloids. Compared with well-established methods towards five-membered-ring-fused indolines, the six-membered-ring-fused indolines are rarely accessed under thermal conditions. Herein, a dearomative [4+2] annulation between different indoles is developed through an electrochemical pathway. This transformation offers a remarkably regio- and stereoselective route to highly functionalized pyrimido[5,4-b]indoles under oxidant- and metal-free conditions. Notably, this electrochemical approach maintains excellent functional-group tolerance and can be extended as a modification tactic for pharmaceutical research. Preliminary mechanism studies indicate that the electrooxidation annulation proceeds through radical-radical cross-coupling between an indole radical cation and an N-centered radical generated in situ.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 161596-47-0 is helpful to your research. Application In Synthesis of (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione.

Application of 161596-47-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 161596-47-0, Name is (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, SMILES is O=C1N(C[C@@H]2OC2)C(C3=C1C=CC=C3)=O, belongs to indolines-derivatives compound. In a article, author is Wen, Ming, introduce new discover of the category.

Mechanism and enantioselectivity of the asymmetric [3+2]-annulation between N-methylindole and enoldiazoacetamide catalyzed by prolinate-coordinated dirhodium: A theoretical study

The mechanistic study of Rh-2(S-MSP)(4)-catalyzed asymmetric [3 + 2]-annulation of N-methylindole and enoldiazoacetamide carbenoid to produce C2,C3-fused indole skeleton has been carried out by combining the density functional theory and semi-empirical method with ONIOM methodology. The mechanism and origin of enantioselectivity were disclosed by our calculations. The cycloaddition process was initiated by vinylogous attack of indole on the mot terminus of carbenoid, which was considered to be the enantio-controlling step. Followed by ring closure step where C-Rh bond adds to the iminium, adduct was afforded enantioselectively. The rate-controlling step, depending on the pathways the reaction proceeds along, could be either one of the two steps. Moreover, we elucidated the effect of weak interaction on the enantioselectivity using the independent gradient model analysis and provided possible insight into reaction design. The catalytic cycle was also kinetically interpreted in a non conventional way, which is the energetic span model, realized by the AUTOF program. (C) 2019 Elsevier Inc. All rights reserved.

Application of 161596-47-0, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 161596-47-0.

Application of 161596-47-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 161596-47-0, Name is (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, SMILES is O=C1N(C[C@@H]2OC2)C(C3=C1C=CC=C3)=O, belongs to indolines-derivatives compound. In a article, author is Gouda, Moustafa A., introduce new discover of the category.

Ascorbic Acid as an Eco-friendly Catalyst for the Efficient Synthesis of Bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) in Aqueous Media

One pot, multi component reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one (1) and aryl aldehydes 2 or 5-substituted indoline-2,3-diones (4a-c) in the presence of ascorbic acid as a unique catalyst in aqueous media afforded the 4, 4′-(arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) (3a-1) and 3, 3-bis(5-hydroxy-3-methyl-1-phenyl- 1H-pyrazol-4-yl)-5-substituted indolin-2-ones (5a-c), respectively. This protocol provides several advantages such as environmental friendliness, excellent yields, and simple workup procedure

Application of 161596-47-0, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 161596-47-0.

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Kukushkin, Maxim E., once mentioned the application of 161596-47-0, Name is (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, molecular formula is C11H9NO3, molecular weight is 203.19, MDL number is MFCD04973350, category is indolines-derivatives. Now introduce a scientific discovery about this category, HPLC of Formula: C11H9NO3.

Synthesis and cytotoxicity of oxindoles dispiro derivatives with thiohydantoin and adamantane fragments

An effective and highly regio- and diastereoselective one-pot synthesis of two types of dispiro heterocyclic systems (2-thioxodispiro[imidazolidine-4,3 ‘-pyrrolidine-2 ‘,3 ”-indoline]-2 ”,5-diones and 2-thioxodispiro[imidazolidine-4,3 ‘-pyrrolidine-4 ‘,3 ”-indoline]-2 ”,5-diones) comprising pyrrolidinyl-oxindole, thiohydantoin and adamantane moieties has been developed based on a 1,3-dipolar cycloaddition of azomethine ylides, generated from isatin and sarcosine or formaldehyde and sarcosine, to adamantane-containing electron-deficient alkenes. Several molecules have demonstrated a considerable cytotoxicity against A549, HEK293T, MCF7 and VA13 cancer cell lines. The possible mechanism of anticancer activity of the synthesized compounds based on literature data may be the inhibition of p53/MDM2 interaction; however, we did not observe significant p53 activation using a reporter construction in A549 cell line in the relevant concentration range.

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