Category: 161596-47-0

Electric Literature of 161596-47-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 161596-47-0, Name is (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, SMILES is O=C1N(C[C@@H]2OC2)C(C3=C1C=CC=C3)=O, belongs to indolines-derivatives compound. In a article, author is Gouda, Moustafa A., introduce new discover of the category.

One pot, multi component reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one (1) and aryl aldehydes 2 or 5-substituted indoline-2,3-diones (4a-c) in the presence of ascorbic acid as a unique catalyst in aqueous media afforded the 4, 4′-(arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) (3a-1) and 3, 3-bis(5-hydroxy-3-methyl-1-phenyl- 1H-pyrazol-4-yl)-5-substituted indolin-2-ones (5a-c), respectively. This protocol provides several advantages such as environmental friendliness, excellent yields, and simple workup procedure

Electric Literature of 161596-47-0, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 161596-47-0.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Adding a certain compound to certain chemical reactions, such as: 161596-47-0, name is (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 161596-47-0, Recommanded Product: 161596-47-0

((S)-2-(oxiran-2-ylmethyl)isoindoline-1,3-dione (4.56g, 22.46mmol, 1.3eq.) and 4-(4-isocyanatophenyl)morpholin-3-one (3.77g, 17.29mmol) were dissolved in isoamyl acetate (70mL) respectively, and heated to 120C. Then magnesium chloride (0.12g, 1.28mmol) was added, the mixture was reacted for 4h, white solid was obtained by filtration (6.97g, yield:95.5%). ESI-MS(m/z): 422(M+H), 444(M+Na); 1HNMR(400MHz, CDCl3) delta: 3.74(m, 2H), 3.94(m, 4H), 4.10(m, 2H), 4.32(s, 2H), 4.98(m, 1H), 7.34(d, 2H), 7.56(d, 2H), 7.75(m, 2H), 7.88(m, 2H); HPLC: 98.82%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, other downstream synthetic routes, hurry up and to see.

Electric Literature of 161596-47-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 161596-47-0 as follows.

[0048] (S)-2-(oxiran-2-ylmethyl)isoindoline-1,3-dione (3.87 g, 19.06 mmol, 1.1 eq.) and 4-(4-isocyanatophenyl)morpholin-3-one (3.77 g, 17.29 mmol) were dissolved in chlorobenzene (70 mL) respectively, then heated to 115 C. and lithium iodide (0.23 g, 1.72 mmol) was added. The mixture was reacted for 4 h, white solid was obtained by filtration (6.85 g, yield: 94.09%). [0049] ESI-MS (m/z): 422 (M+H), 444 (M+Na); [0050] 1HNMR (400 MHz, CDCl3) delta: 3.74 (m, 2H), 3.94 (m, 4H), 4.10 (m, 2H), 4.32 (s, 2H), 4.98 (m, 1H), 7.34 (d, 2H), 7.56 (d, 2H), 7.75 (m, 2H), 7.88 (m, 2H); [0051] HPLC: 98.91%.

According to the analysis of related databases, 161596-47-0, the application of this compound in the production field has become more and more popular.

Reference of 161596-47-0, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 161596-47-0, Name is (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, SMILES is O=C1N(C[C@@H]2OC2)C(C3=C1C=CC=C3)=O, belongs to indolines-derivatives compound. In a article, author is Huang, Jiann-Jyh, introduce new discover of the category.

In this study, we reported the inhibition profiles of 4 ‘-acylpyrrole-5-fluoroindolin-2-one 3 with a C-3 ‘ side chain for VEGFR2, PDGFR-beta, and FGFR-1 protein kinases. The pyrrole-fused cyclohexanone moiety provided 3 with the best potency to inhibit the three kinases, and the C-3 ‘ side chains contributed to the different inhibition profiles of 3. Compound 3b with a C-3 ‘ 2-carboxylethyl side chain showed good potency for the three kinase (IC50: 25-260 nM), and compound 3g with a N,N-dialkyl-2-carbamoylethyl side chain was more active for VEGFR2 (IC50: 59 nM) and PDGFR-beta (IC50: 16 nM) than FGFR-1 (IC50: 1.7 mu M). The C-3 ‘ 3-(dialkylamino)propyl side chain accomplished 3h-j as selective PDGFR-beta inhibitors (IC50: 7.8-13 nM). Compound 3b was further investigated and found potent to inhibit VEGF- and FGF-dependent cell proliferation with moderate in vivo anticancer activity. Results from docking simulations revealed that the interactions of 3b with VEGFR2 and FGFR-1 which could account for the different inhibition profiles of 3.

Reference of 161596-47-0, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 161596-47-0.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 161596-47-0, Name is (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, SMILES is O=C1N(C[C@@H]2OC2)C(C3=C1C=CC=C3)=O, in an article , author is Lei, Jie, once mentioned of 161596-47-0, HPLC of Formula: C11H9NO3.

Synthesis of indoline-piperidinones via a novel Ugi, ring expansion, pseudo-Dieckmann condensation and rearrangement cascade reaction

An Ugi, ring expansion, pseudo-Dieckmann condensation and rearrangement cascade reaction was discovered for the synthesis of indoline-piperidinones in one pot. A series of targeted compounds was prepared by means of a mild reaction and a simple operation procedure, which could be applicable to a broad scope of Ugi starting materials. This cascade reaction generates opportunities for the tailored synthesis of a wide range of indoline-piperidinone scaffolds through tuneable Ugi inputs.

Interested yet? Read on for other articles about 161596-47-0, you can contact me at any time and look forward to more communication. HPLC of Formula: C11H9NO3.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 161596-47-0, Name is (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, molecular formula is C11H9NO3. In an article, author is Yang, Wu-Lin,once mentioned of 161596-47-0, Name: (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione.

Highly Regio-, Diastereo-, and Enantioselective Assembly of Azepino[2,3-b]indoles via Palladium-Catalyzed [4+3] Cycloaddition

A Summary of main observation and conclusion A palladium-catalyzed asymmetric [4 + 3] cycloaddition of trimethylenemethanes and indoline-derived aza-dienes has been developed. The potential [3 + 2] side pathway was completely suppressed in the process. This protocol provides an efficient access to azepino[2,3-b]indoles bearing two vicinal stereocenters in generally excellent diastereo- and enantioselectivities (up to > 20 : 1 dr, 99% ee).

Interested yet? Keep reading other articles of 161596-47-0, you can contact me at any time and look forward to more communication. Name: (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione.

Synthetic Route of 161596-47-0, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 161596-47-0, Name is (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, SMILES is O=C1N(C[C@@H]2OC2)C(C3=C1C=CC=C3)=O, belongs to indolines-derivatives compound. In a article, author is Huang, Jiann-Jyh, introduce new discover of the category.

The inhibition profiles of 4′-acylpyrrole-5-fluoroindolin-2-ones with a C-3′ side chain for VEGFR2, PDGFR-beta, and FGFR-1 protein kinases

In this study, we reported the inhibition profiles of 4 ‘-acylpyrrole-5-fluoroindolin-2-one 3 with a C-3 ‘ side chain for VEGFR2, PDGFR-beta, and FGFR-1 protein kinases. The pyrrole-fused cyclohexanone moiety provided 3 with the best potency to inhibit the three kinases, and the C-3 ‘ side chains contributed to the different inhibition profiles of 3. Compound 3b with a C-3 ‘ 2-carboxylethyl side chain showed good potency for the three kinase (IC50: 25-260 nM), and compound 3g with a N,N-dialkyl-2-carbamoylethyl side chain was more active for VEGFR2 (IC50: 59 nM) and PDGFR-beta (IC50: 16 nM) than FGFR-1 (IC50: 1.7 mu M). The C-3 ‘ 3-(dialkylamino)propyl side chain accomplished 3h-j as selective PDGFR-beta inhibitors (IC50: 7.8-13 nM). Compound 3b was further investigated and found potent to inhibit VEGF- and FGF-dependent cell proliferation with moderate in vivo anticancer activity. Results from docking simulations revealed that the interactions of 3b with VEGFR2 and FGFR-1 which could account for the different inhibition profiles of 3.

Synthetic Route of 161596-47-0, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 161596-47-0.

Synthetic Route of 161596-47-0, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 161596-47-0, Name is (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, SMILES is O=C1N(C[C@@H]2OC2)C(C3=C1C=CC=C3)=O, belongs to indolines-derivatives compound. In a article, author is Shigemitsu, Yasuhiro, introduce new discover of the category.

Numerical Analysis of Solute-Solvent Coupling Magnitude in the Thermally Backward Ring Closing Reaction of Spirooxazines

A fundamental involvement of solvent fluctuations often arises in solution reactions, where the coupling between the solute structural change and solvent fluctuations plays a decisive role in reaction kinetics. In this study, the rate constants associated with the ring-closing reaction of 1,3,3-trimethylspiro(indoline-2,3 ‘-naphtho[2,1-b][1,4]oxazine) (SNO) are numerically analyzed by means of the one-dimensional Grote-Hynes model and two-dimensional Fokker-Planck equation with sink term model, respectively. The solute-solvent coupling parameterC(coupled)was evaluated in terms of the non-equilibrium solvation energy, which was directly computed by molecular dynamics (MD) simulations. The correlation between the solute-solvation coupling magnitude and the ring closure mechanism in solution are discussed.

Synthetic Route of 161596-47-0, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 161596-47-0 is helpful to your research.

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 161596-47-0, Name is (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione. In a document, author is Islam, Mohammad Shahidul, introducing its new discovery. Quality Control of (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione.

Synthesis, Anticancer Activity, and Molecular Modeling of New Halogenated Spiro[pyrrolidine-thiazolo-oxindoles] Derivatives

A one-pot, single-step, and an atom-economical process towards the synthesis of highly functionalized spirooxindoles analogues was efficiently conducted to produce a satisfactory chemical yields (70-93%) with excellent relative diastereo-, and regio-selectivity. An in vitro antiproliferative assay was carried out on different cancer cell lines to evaluate the biological activity of the synthesized tetrahydro-1’H-spiro[indoline-3,5′-pyrrolo[1,2-c]thiazol]-2-one 5a-n. The prepared hybrids were then tested in vitro for their antiproliferative effects against three cancer cell lines, namely, HepG2 (liver cancer), MCF-7 (breast cancer), and HCT-116 (colon cancer). The spirooxindole analogue 5g exhibited a broad activity against HepG2, MCF-7, and HCT-116 cell lines of liver, breast, and colorectal cancers when compared to cisplatin. Modeling studies including shape similarity, lipophilicity scores, and physicochemical parameters were calculated. The results of this study indicated that spirooxindole analogue 5g retained a good physiochemical parameters with acceptable lipophilicity scores.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 161596-47-0 help many people in the next few years. Quality Control of (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione.

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.161596-47-0, Name is (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, SMILES is O=C1N(C[C@@H]2OC2)C(C3=C1C=CC=C3)=O, belongs to indolines-derivatives compound. In a document, author is Hussein, Essam M., introduce the new discover, Recommanded Product: 161596-47-0.

Unprecedented Regio- and Stereoselective Synthesis of Pyrene-Grafted Dispiro[indoline-3,2 ‘-pyrrolidine-3 ‘,3 ”-indolines]: Expedient Experimental and Theoretical Insights into Polar [3+2] Cycloaddition

A series of dispiro[indoline-3,2′-pyrrolidine-3’,3 ”-indolines] was synthesized via a multicomponent polar [3 + 2] cycloaddition (32CA) reaction of isatin derivatives, sarcosine and (E)-3-(2-oxo-2-(pyren-1-yl)ethylidene)indolin-2-one derivatives. The regio- and stereochemistries of the cycloadducts were established on the basis of one-dimensional (1D) (H-1-, C-13-, C-13-CRAPT NMR) and two-dimensional (2D) homonuclear and heteronuclear correlation NMR spectrometry experiments (H-1-H-1 gDQFCOSY, C-13-H-1-HSQCAD, C-13-H-1-HMBCAD, H-1-H-1-ROESYAD). The molecular mechanism and regio- and stereoselectivities of the cycloaddition (CA) reaction have been investigated utilizing a density functional theory (DFT) method and were thoroughly explained based on the transition-state stabilities and global/local electrophilicity/nucleophilicity reactivity indices of the reactants.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 161596-47-0 is helpful to your research. Recommanded Product: 161596-47-0.