Category: 15937-07-2

Adding a certain compound to certain chemical reactions, such as: 15937-07-2, name is 5,6-Dimethoxyindoline, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15937-07-2, Product Details of 15937-07-2

The experimental steps and operations are: at room temperature,18 g of Compound 2 was dissolved in 200 mL of acetonitrile, and the mixture was vigorously stirred in an environment where the container was exposed to air or oxygen, and the reaction was continued.The TLC tracks the reaction until the material completely disappears, which takes approximately 16-24 hours.The crude product was concentrated under reduced pressure on a rotary evaporator, and purified using silica gel column chromatography eluting with petroleum ether ethyl acetate (90:10, v/v).Obtaining Compound 3 as a colorless crystal; placing a single crystal in the receiving bottle. The weight of the compound 3 was 11.5 g, and the yield was 71% (the total yield of the two-step reaction).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,6-Dimethoxyindoline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Yantai Liudi Pharmaceutical Technology Co., Ltd.; Yang Jiade; Wang Xiujie; Fan Yulong; Qu Wenchao; Chen Tingting; (14 pag.)CN108484471; (2018); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Related Products of 15937-07-2, The chemical industry reduces the impact on the environment during synthesis 15937-07-2, name is 5,6-Dimethoxyindoline, I believe this compound will play a more active role in future production and life.

1st Stage 7.1 g of 2-chloro-5-nitropyridine (0.045 mol) were stirred with 8.0 g of 5,6-dimethoxyindoline (0.045 mol) and 4.2 g of sodium hydrogen carbonate (0.050 mol) for 2.5 h at 80 C. in 50 ml of DMSO. After cooling, the mixture was poured onto ice, the precipitate was removed by filtration under suction and the product was dried in vacuo at 45 C. The intermediate product 5,6-dimethoxy-1-(5-nitro-(2-pyridyl)-indoline was obtained in a yield of 23.1% (melting point: 202-207 C.).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,6-Dimethoxyindoline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Naumann, Frank; Hollenberg, Detlef; Hoeffkes, Horst; Rose, David; US2004/6834; (2004); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Related Products of 15937-07-2,Some common heterocyclic compound, 15937-07-2, name is 5,6-Dimethoxyindoline, molecular formula is C10H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 4: To a solution of 2-(4-nitro-1 H-pyrazol-1 -yl)acetaldehyde (942 mg, 6.08 mmol) in DCM (60.0 mL), 5,6-dimethoxyindoline (from step 1 ) (1 .09 g, 6.08 mmol) and STAB (1.55 g, 7.29 mmol) was added. After stirring at rt fori h, the reaction mixture was quenched with water and extracted with DCM (2x). The combined org. layers were concentrated and purification was performed by FC (EtOAc/ hex 1 :4 to 1 :1 ) to yield 5,6-dimethoxy-1-(2-(4-nitro- 1 H-pyrazol-1 -yl)ethyl)indoline as a brown solid. LC-MS conditions B: tR = 0.65 min, [M+H]+= 319.19.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5,6-Dimethoxyindoline, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 15937-07-2, name is 5,6-Dimethoxyindoline, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15937-07-2, HPLC of Formula: C10H13NO2

1st Stage 6.3 g of 4-nitrofluorobenzene (0.045 mol) were stirred with 8.0 g of 5,6-dimethoxyindoline (0.045 mol) and 4.2 g of sodium hydrogen carbonate (0.050 mol) for 2.5 h at 80 C. in 50 ml of DMSO. After cooling, the mixture was poured onto ice, the precipitate was removed by filtration under suction and the product was dried in vacuo at 45 C. The intermediate product 5,6-dimethoxy-1-(4-nitrophenyl)-indoline was obtained in a yield of 65.6% (melting point: 176-179 C.).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,6-Dimethoxyindoline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Naumann, Frank; Hollenberg, Detlef; Hoeffkes, Horst; Rose, David; US2004/6834; (2004); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem