Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 153744-36-6, name is Methyl 3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropanoate, A new synthetic method of this compound is introduced below., Formula: C12H11NO5
General procedure: tert-Butyl(2-iodoethoxy) diphenylsilane (1.4 eq) andAg2CO3 (4.0 eq) were added to a suspension of the aminoacid derivative (1.0 eq) in toluene (10.0 ml). The reactionmixture was stirred in a pressure tube at 120 C until TLCindicated complete consumption of the amino acid derivative,cooled to rt, filtered through a paper filter and reducedin vacuum. The residue was purified by flash columnchromatography on silica (eluent: pentane/Et2O 7:3).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.