Sources of common compounds: 15362-40-0

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, A new synthetic method of this compound is introduced below., name: 1-(2,6-Dichlorophenyl)-2-indolinone

Example 1Step a) of preparation of sodium diclofenacIn a four-necked glass flask the following ingredients were charged:- 1 -(2,6-dichlorophenyl)-2-indolinone g 592 (M.W. 278.13 moles: 2.128)- Water cc 2368- Sodium hydrosulfite g 40- Sodium hydroxide 30 % g 851 (M.W.: 40; moles: 6.38)The mixture was refluxed for 6 hours, then cooled to 35 – 37 C. The precipitate was filtered on buchner funnel, then washed with water (cc 1600) preheated to 35- 37 C. Wet 1016 grams of sodium diclofenac were obtained corresponding to dry 625 grams (Theor. g 677.1 )

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; COSMA S.P.A.; IBSA INSTITUT BIOCHIMIQUE S.A.; AVOGADRI, Alvaro; LUSSANA, Massimiliano; PIZZATTI, Enrica; BARETTI, Sergio; WO2010/69397; (2010); A1;,
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Application of 15362-40-0

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(2,6-Dichlorophenyl)-2-indolinone, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15362-40-0, SDS of cas: 15362-40-0

General procedure: Aldehyde (1 mmol) and active methylene component (2.5 mmol) were dissolved in dimethylformamide in a microwave vial, piperidine was added in catalytic amount andthen the reaction mixture was subjected to microwave irradiations for 1h at 150 C. A solid product was separated out which was then filtered andwashed with cold water. The products were further purified by washing with ether/ethanol.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(2,6-Dichlorophenyl)-2-indolinone, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kaur, Jagroop; Kaur, Sukhmeet; Singh, Palwinder; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 1936 – 1940;,
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Continuously updated synthesis method about 15362-40-0

The synthetic route of 15362-40-0 has been constantly updated, and we look forward to future research findings.

Application of 15362-40-0,Some common heterocyclic compound, 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, molecular formula is C14H9Cl2NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a four-necked flask was added compound IV (233 g, 0.84 mol), potassium hydroxide (94.3 g, 1.68 mol), 10% hydrochloric acid 668 mL, zinc hydroxide (167 g, 1.68 mol), and the temperature was raised to 85 C for 8 hours , Cooling to 60 ~ 65 , vacuum filtration, filter cake and add a small amount of water to get 499.5g (compound I: diclofenac zinc), the yield of 91%.

The synthetic route of 15362-40-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jilin University; Liaoyuan Yinying Pharmaceutical Co., Ltd.; Li Guiying; Wang Zhaokun; Li Shumei; Peng Xiaojuan; Jin Xingtong; (8 pag.)CN106905178; (2017); A;,
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Research on new synthetic routes about 15362-40-0

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15362-40-0, Computed Properties of C14H9Cl2NO

General procedure: A finely ground mixture of 5-substituted indole-3-carboxaldehyde (1 mmol) and active methylene compound (indolinone/oxindole/barbituric acid/1-(3-chlorophenyl)-3-methyl-2-pyrazolin-5-one)/2-trifluoromethylbenzaldehyde (1.2 mmol) was irradiated in microwave oven for 1-5 min. The solid product was washed with diethyl ether and purified by column chromatography to get pure products 2-5 and 11-28 except compound 3. Compound 3 was prepared by treatment of 5-substituted indole-3-carboxaldehyde with indolinone in ethanol-water in presence of NaOH (1.5 mmol).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Shaveta; Singh, Palwinder; European Journal of Medicinal Chemistry; vol. 74; (2014); p. 440 – 450;,
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Extracurricular laboratory: Synthetic route of 15362-40-0

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 15362-40-0, its application will become more common.

Some common heterocyclic compound, 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, molecular formula is C14H9Cl2NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C14H9Cl2NO

Pyrrole-2-carboxaldehyde (1 mmol) and 1-(chloromethyl)naphthalene (1.5 mmol) were exposed to react in the presence of NaH (1.5 mmol) in DMF (solvent) at 0 – 25 C for 45 min, the progress of the reaction was monitored with TLC. After completion, the reaction was quenched by the addition of water and the product was extracted with ethyl acetate (2 x 50 ml). The organic layers were combined, dried over Na2SO4 and distilled in vacuum to give 1-(naphthalen-1-ylmethyl)-1H-pyrrole-2-carbaldehyde (A) which was purified by column chromatography using ethyl acetate: hexane (2:48). A (1 mmol) was reacted with 1-(2,6-dichlorophenyl)-2-indolinone (1.2 mmol) in the presence of piperidine (0.2 mmol) in CHCl3/ DMF under microwave irradiations at 100 C for 1h. The progress of the reaction was monitored with TLC. After completion, the reaction was worked up by adding water and extracted with chloroform (2 x 50 ml). Combined organic layers were dried over Na2SO4 and distilled in vacuum to procure crude product 3d which was further purified by column chromatography using ethyl acetate: hexane (2:50) as eluent to get two inseparable isomers (1:2 1H NMR spectrum). Yellow Solid, yield 68 %, mp 180-182 C; IR (KBr): 2853, 3066, 1699, 1598, 1484, 1391; 1H NMR (500 MHz, CDCl3) delta: 5.78 (s, 2H, CH2 maj), 5.87 (s, 2H, CH2 min), 6.39-6.46 (m, 4H, 2ArHmaj + 2ArHmin), 6.83-6.84 (m, 1H, ArHmaj), 6.90-6.94 (m, 1H, ArHmin), 6.96 (d, J = 6.8 Hz, 1H, ArHmin), 7.0-7.01(m, 1H, ArHmin), 7.02 (d, J = 6.8 Hz, 1H, ArHmaj), 7.07-7.17 (m, 3H, 1ArHmaj + 2ArHmin), 7.21-7.24 (m, 1H, ArHmaj), 7.35-7.40 (m, 3H, 2ArHmaj + 1ArHmin), 7.41-7.45 (m, 2H, 1ArHmaj + 1ArHmin), 7.47 (s, 2H, ArHmin), 7.51(d, J = 8.0 Hz, 3H, 2ArHmaj+1ArHmin), 7.54-7.58 (m, 3H, 2ArHmaj + 1ArHmin), 7.60-7.68 (m, 2H, 1ArHmin), 7.84-7.87 (m, 3H, 2ArHmaj + 1ArHmin), 7.91-7.93 (m, 2H, ArHmaj), 7.98 (d, J = 7.78 Hz, 1H, ArHmin), 8.06 (d, J = 8.32 Hz, 1H, ArHmin), 8.35 (d, J = 7.75 Hz, 1H, ArHmaj), 8.55-8.56 (m, 1H, ArHmin); 13C NMR (125 MHz, CDCl3) delta:48.7, 49.0, 108.6, 109.0, 110.3, 110.9, 116.4, 117.3, 117.9, 120.8, 121.9, 122.0, 122.10, 122.13, 122.4, 122.5, 122.6, 122.7, 124.8, 125.0, 125.4, 125.6, 125.8, 126.1, 126.2, 126.8, 126.9, 127.1, 127.3, 128.5, 128.7, 128.75, 128.8, 128.9, 129.0, 129.1, 129.2, 130.2, 130.4, 130.5, 130.7, 130.8, 131., 132.1, 132.4, 133.6, 135.8, 136.0, 139.2, 141.3, 164.9, 167.8; HRMS (ESI) m/z for C30H20Cl2N2O [M+H]+ calcd. 495.1025, found 495.1041.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 15362-40-0, its application will become more common.

Reference:
Article; Kaur, Jagroop; Kaur, Baljit; Singh, Palwinder; Bioorganic and Medicinal Chemistry Letters; vol. 28; 2; (2018); p. 129 – 133;,
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New downstream synthetic route of 15362-40-0

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 15362-40-0.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, This compound has unique chemical properties. The synthetic route is as follows., Formula: C14H9Cl2NO

Example Vl; 1 -(2,6-dichloro-phenyl)-5-nitro-1 ,3-dihvdro-indol-2-one600 mg 1 -(2,6-dichloro-phenyl)-1 ,3-dihydro-indol-2-one are dissolved in 5 ml concentrated sulphuric acid and cooled to 00C . To this is added dropwise a solution of 160 mul concentrated nitric acid in 1 ml concentrated sulphuric acid.The mixture is stirred for 30 minutes and then added to 50 g ice. Then the mixture is stirred for 1 hour and the solid is suction filtered. After drying in vacuo the solid is chromatographed on silica gel (cyclohexane/ethyl acetate 70:30 to 20:80).Yield: 310 mg (44 % of theory)Mass spectrum (ESI+): m/z = 323 [M+H]+

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 15362-40-0.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2009/16118; (2009); A1;,
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Continuously updated synthesis method about 15362-40-0

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 15362-40-0, other downstream synthetic routes, hurry up and to see.

A common compound: 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, belongs to indolines-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 15362-40-0

General procedure: A finely ground mixture of chromone-3-carboxaldehyde(1 mmol) and oxindole/indolinone (1-(2,6-dichlorophenyl)-2-indolinone)/1-(3-chlorophenyl)-3-methyl-2-pyrazolin-5-one (1.2 mmol) was irradiated in microwave oven for 1 min and completion of the reaction was monitored with TLC. Reaction mixture was washed with diethyl ether to get pure compounds 5-10.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 15362-40-0, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Shaveta; Singh, Amrinder; Kaur, Matinder; Sharma, Surbhi; Bhatti, Rajbir; Singh, Palwinder; European Journal of Medicinal Chemistry; vol. 77; (2014); p. 185 – 192;,
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Simple exploration of 15362-40-0

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 15362-40-0.

These common heterocyclic compound, 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 15362-40-0

General procedure: A finely ground mixture of 5-substituted indole-3-carboxaldehyde (1 mmol) and active methylene compound (indolinone/oxindole/barbituric acid/1-(3-chlorophenyl)-3-methyl-2-pyrazolin-5-one)/2-trifluoromethylbenzaldehyde (1.2 mmol) was irradiated in microwave oven for 1-5 min. The solid product was washed with diethyl ether and purified by column chromatography to get pure products 2-5 and 11-28 except compound 3. Compound 3 was prepared by treatment of 5-substituted indole-3-carboxaldehyde with indolinone in ethanol-water in presence of NaOH (1.5 mmol).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 15362-40-0.

Reference:
Article; Shaveta; Singh, Palwinder; European Journal of Medicinal Chemistry; vol. 74; (2014); p. 440 – 450;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Extended knowledge of 15362-40-0

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1-(2,6-Dichlorophenyl)-2-indolinone.

Adding some certain compound to certain chemical reactions, such as: 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15362-40-0. 15362-40-0

General procedure: Compounds 4-9 were prepared through knoevenagel condensation of compounds 12 and 13 (1 mmol) with active methylene compounds including 1-(3-chlorophenyl)-3-methyl-2-pyrazolin-5-one, oxindole and indolinone (1 mmol). The reactants were heated at 160-180 C for about 10-20 min in oil bath and the completion of the reaction was monitored using TLC. The crude products were solidified by triturating with diethyl ether and purified by recrystallization and column chromatography.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1-(2,6-Dichlorophenyl)-2-indolinone.

Reference:
Article; Singh, Palwinder; Shaveta; Sharma, Surbhi; Bhatti, Rajbir; Bioorganic and Medicinal Chemistry Letters; vol. 24; 1; (2014); p. 77 – 82;,
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Sources of common compounds: 15362-40-0

The chemical industry reduces the impact on the environment during synthesis 15362-40-0. I believe this compound will play a more active role in future production and life.

The chemical industry reduces the impact on the environment during synthesis 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, I believe this compound will play a more active role in future production and life. 15362-40-0

Pyrrole-2-carboxaldehyde (1 mmol) and 4-chlorobenzyl chloride (1.5 mmol) were reacted in the presence of NaH (1.5 mmol) in DMF (solvent) at 0 – 25 C for 30 min. The progress of the reaction was monitored with TLC. After the completion, reaction was quenched by adding water and worked up by extraction with ethyl acetate (2 x 50 ml). The organic layers were combined, dried over Na2SO4 and distilled in vacuum to give N-(4-chlorobenzyl)pyrrole-2-carboxaldehyde (A) which was further purified by column chromatography using ethyl acetate: hexane (1:50). A (1 mmol) was reacted with 1-(2,6-dichlorophenyl)-2-indolinone (1.2 mmol) in the presence of piperidine (0.2 mmol) in CHCl3/ DMF under microwave irradiations at 100 C for 1h. The progress of the reaction was monitored with TLC. After completion, the reaction was worked up by adding water and extraction with chloroform (2 x 50 ml). Combined organic layers were dried over Na2SO4 and distilled in vacuum to give crude product 3c which was purified by column chromatography using ethyl acetate: hexane (3:50) as eluent. Yellow Solid, yield 70 %, mp 122-124 C; IR (KBr): 3054, 2928, 1698, 1600, 1485, 1367; 1H NMR (500 MHz, CDCl3) delta: 1H NMR (500 MHz, CDCl3, 25 C, TMS ) delta: 5.29 (s, 2H, CH2), 6.44-6.46 (m, 2H, ArH), 6.97-6.98 (m, 1H, ArH), 7.08-7.10 (m, 3H, ArH), 7.21 (t, 1H, J = 6.74 Hz, ArH), 7.31 (d, 2H, J = 8.48 Hz, ArH), 7.37-7.41 (m, 2H, ArH), 7.53 (d, 2H, J = 8.52 Hz, ArH), 7.71 (s, 1H, =CH), 8.25 (d, 1H, J = 7.4 Hz, ArH), 8.23 (dd, 1H, J = 4.37 Hz, 1.29 Hz, ArH) ; 13C NMR (125 MHz, CDCl3, normal/DEPT-135) delta: 50.4 (-ve, CH2), 109.0 (+ve, CH), 110.5 (+ve, CH), 116.5 (+ve CH), 117.4 (ArC), 117.8 (+ve, CH), 121.9 (ArC), 122.0 (+ve, CH), 122.4 (+ve, CH), 122.5 (+ve, CH), 124.8 (+ve CH), 127.1 (+ve, CH), 127.5 (+ve, CH), 128.1 (+ve, CH), 128.9 (ArC), 129.1 (+ve, CH), 129.3 (+ve, CH), 130.5 (+ve, CH), 133.8 (ArC), 135.5 (ArC), 135.8 (ArC), 141.3 (ArC), 164.8 (CF), 167.8 (C=O); HRMS (ESI) m/z for C26H17Cl3N2O [M+H]+ calcd. 479.0479, found 479.0421.

The chemical industry reduces the impact on the environment during synthesis 15362-40-0. I believe this compound will play a more active role in future production and life.

Reference:
Article; Kaur, Jagroop; Kaur, Baljit; Singh, Palwinder; Bioorganic and Medicinal Chemistry Letters; vol. 28; 2; (2018); p. 129 – 133;,
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