Category: 15362-40-0

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To the four-necked flask was added 668 ml of water and then compound IV (233 g, 0.84 mol), potassium hydroxide (94.3 g,1.68 mol), heated to 100 C for 5 hours, cooled to 60 C to 65 C,Vacuum filter, add a small amount of water, filter cake at 85 CAfter dissolution in water, zinc chloride (229 g, 1.68 mol 1) in water was added, reacted at 85 C for 1 hour,Cooling, filtration was white solid 488.5g (compound I: diclofenac zinc), the yield of 89%

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Reference:
Patent; Jilin University; Liaoyuan Yinying Pharmaceutical Co., Ltd.; Li Guiying; Wang Zhaokun; Li Shumei; Peng Xiaojuan; Jin Xingtong; (8 pag.)CN106905178; (2017); A;,
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Recommanded Product: 15362-40-0,Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations.

27.8 g (0.1 mol) of 1-(2,6-dichlorophenyl)-2-indanone (II) was dissolved in 100 mL of toluene.Then add 5g of triethylbenzylammonium chloride (TEBAC),50 mL of 30% sodium hydroxide solution, stirred and refluxed for 10 h.Stop the reaction,Add 80mL of water,Change to a distillation unit.Toluene is removed by azeotropic distillation,The residual liquid was allowed to stand, cooled, and a large amount of solid was precipitated.filter,It was recrystallized from 100 mL of water and decolorized with activated carbon to give a white solid (26.6 g).

The synthetic route of 15362-40-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Chinese People’s Liberation Army Fanghua College; Tian Xingtao; Ren Lijun; Xiang Yulian; Fan Qiping; Huang Zhiping; Chen Hong; Zhou Lei; (8 pag.)CN103145574; (2018); B;,
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Related Products of 15362-40-0, The chemical industry reduces the impact on the environment during synthesis 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, I believe this compound will play a more active role in future production and life.

General procedure: Compounds 4-9 were prepared through knoevenagel condensation of compounds 12 and 13 (1 mmol) with active methylene compounds including 1-(3-chlorophenyl)-3-methyl-2-pyrazolin-5-one, oxindole and indolinone (1 mmol). The reactants were heated at 160-180 C for about 10-20 min in oil bath and the completion of the reaction was monitored using TLC. The crude products were solidified by triturating with diethyl ether and purified by recrystallization and column chromatography.

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Reference:
Article; Singh, Palwinder; Shaveta; Sharma, Surbhi; Bhatti, Rajbir; Bioorganic and Medicinal Chemistry Letters; vol. 24; 1; (2014); p. 77 – 82;,
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Related Products of 15362-40-0, A common heterocyclic compound, 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, molecular formula is C14H9Cl2NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 4Step a) of preparation of Potassium diclofenacIn a four-necked glass flask the following ingredients were charged:1 -(2,6-dichlorophenyl)-2-indolinone g 100 (moles: 0.359) – Water cc 435- Sodium hydrosulfite g 4- Potassium hydroxide 90 % g 33.6 (moles: 0.539)The mixture was refluxed for 8h 30 min, then cooled to 35 – 37 C. The precipitate was filtered on buchner funnel, then washed with a 1 % NaCI solution in water (cc 70) preheated to 35 C. Wet 180,2 grams of potassium diclofenac were obtained corresponding to dry 1 12,1 grams (Theor. g 120.17).

The synthetic route of 15362-40-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; COSMA S.P.A.; IBSA INSTITUT BIOCHIMIQUE S.A.; AVOGADRI, Alvaro; LUSSANA, Massimiliano; PIZZATTI, Enrica; BARETTI, Sergio; WO2010/69397; (2010); A1;,
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Synthetic Route of 15362-40-0,Some common heterocyclic compound, 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, molecular formula is C14H9Cl2NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A finely ground mixture of chromone-3-carboxaldehyde(1 mmol) and oxindole/indolinone (1-(2,6-dichlorophenyl)-2-indolinone)/1-(3-chlorophenyl)-3-methyl-2-pyrazolin-5-one (1.2 mmol) was irradiated in microwave oven for 1 min and completion of the reaction was monitored with TLC. Reaction mixture was washed with diethyl ether to get pure compounds 5-10.

The synthetic route of 15362-40-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Shaveta; Singh, Amrinder; Kaur, Matinder; Sharma, Surbhi; Bhatti, Rajbir; Singh, Palwinder; European Journal of Medicinal Chemistry; vol. 77; (2014); p. 185 – 192;,
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Related Products of 15362-40-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: The desired compounds 2(a-d), 3(b-d) and 4(b-d) were procured by subjecting an equivalent mixture of compounds 9 (a-d) (1 mmol) and an active methylene compound- barbituric acid, oxindole and indolinone (1 mmol), respectively in methanol (2 mL) using catalytic amount of piperidine to microwave irradiations at 120 oC for 30 min. The reaction was monitored by TLC after every 10 min. The yellow solid obtained was filtered followed by washing with methanol and dried in air.

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Reference:
Article; Kaur, Manpreet; Singh, Palwinder; Bioorganic and Medicinal Chemistry Letters; vol. 29; 1; (2019); p. 32 – 35;,
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Application of 15362-40-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: An equivalent mixture of aldehyde (1 mmol) and active methylene compound- barbituric acid/1, 3-dimethyl barbituric acid/ 1-(3-chlorophenyl)-3-methyl-2-pyrazolin-5-one (1 mmol) in dimethyl formamide (2 mL) was subjected to microwave irradiations at 150 C for 1 h. The reaction was monitored by TLC. After the completion, the reaction was quenched by adding water to the reaction mixture. The crude product was separated out as solid, which was further purified by washing with ethanol, hot water and recrystallization from chloroform:methanol (9:1).

The synthetic route of 1-(2,6-Dichlorophenyl)-2-indolinone has been constantly updated, and we look forward to future research findings.

Reference:
Article; Singh, Harpreet; Kaur, Manpreet; Kaur, Harpreet; Sharma, Indu; Bhandari, Anmol; Kaur, Gurcharan; Singh, Palwinder; Bioorganic and Medicinal Chemistry Letters; vol. 29; 19; (2019);,
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Reference of 15362-40-0, The chemical industry reduces the impact on the environment during synthesis 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, I believe this compound will play a more active role in future production and life.

Pyrrole-2-carboxaldehyde (1 mmol) was treated with benzyl bromide (1.5 mmol) in the presence of NaH (1.5 mmol) in DMF (solvent) at 0 C for 15 min, the progress of the reaction was monitored with TLC and the reaction was shifted to room temp for another 15 min. After completion, the reaction was quenched by adding water and the crude product was isolated by extraction with ethyl acetate (2 x 50 ml), the organic layers were combined, dried over Na2SO4 and distilled in vacuum to give N-benzylpyrrole-2-carboxaldehyde (A) which was further purified by column chromatography using ethyl acetate: hexane (1:50). N-benzylpyrrole-2-carboxaldehyde (A, 1 mmol) was reacted with 1-(2,6-dichlorophenyl)-2-indolinone (1.2 mmol) in the presence of piperidine (0.2 mmol) in CHCl3/ DMF under microwave irradiations at 100 C for 1h. The progress of the reaction was monitored with TLC. After completion, the reaction was worked up by adding water and extraction with chloroform (2 x 50 ml). Combined organic layers were dried over Na2SO4 and distilled in vacuum to give crude product 3a which was purified by column chromatography using ethyl acetate:hexane (3:50) as eluent. Yellow Solid, yield 62%, mp 153-155 C; IR (KBr): 3059, 2925, 1695, 1599, 1485, 1365; 1H NMR (500 MHz, CDCl3, 25 C, TMS) delta: 5.41 (s, 2H, CH2), 6.40-6.41 (m, 2H, ArH), 7.04 (t, 1H, J = 7.5 Hz, ArH), 7.07 (s, 1H, ArH), 7.13 (t, 1H, J = 7.6 Hz, ArH), 7.19 (d, 2H, J = 7.4 Hz, ArH), 7.29-7.34 (m, 2H, ArH), 7.36-7.41 (m, 3H, ArH), 7.47 (s, 1H, =CH), 7.52 (d, 2H, J = 8.09 Hz, ArH), 8.49 (dd, 1H, J = 4.13 Hz, 1.29 Hz, ArH); 13C NMR (125 MHz, CDCl3, normal/DEPT-135) delta: 51.3 (-ve, CH2), 108.6 (+ve, CH), 110.7, (+ve, CH), 117.1 (ArC), 117.8 (+ve,CH), 121.9 (+ve, CH), 122.1 (+ve, CH), 123.0 (+ve, CH), 125.2 (ArC), 126.2 (+ve, CH), 126.9 (+ve, CH), 127.1 (+ve, CH), 128.0 (+ve, CH), 128.7 (ArC), 128.8 (+ve, CH), 128.9 (+ve, CH), 129.1 (+ve, CH), 129.2 (+ve, CH), 130.1 (+ve, CH), 131.4 (ArC), 135.9 (ArC), 137.3 (ArC), 139.2 (ArC), 164.8 (C=O); HRMS (ESI) m/z for C26H18Cl2N2O [M+H]+ calcd. 445.0868, found 445.0817.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(2,6-Dichlorophenyl)-2-indolinone, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kaur, Jagroop; Kaur, Baljit; Singh, Palwinder; Bioorganic and Medicinal Chemistry Letters; vol. 28; 2; (2018); p. 129 – 133;,
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15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 1-(2,6-Dichlorophenyl)-2-indolinone

General procedure: A finely ground mixture of 5-substituted indole-3-carboxaldehyde (1 mmol) and active methylene compound (indolinone/oxindole/barbituric acid/1-(3-chlorophenyl)-3-methyl-2-pyrazolin-5-one)/2-trifluoromethylbenzaldehyde (1.2 mmol) was irradiated in microwave oven for 1-5 min. The solid product was washed with diethyl ether and purified by column chromatography to get pure products 2-5 and 11-28 except compound 3. Compound 3 was prepared by treatment of 5-substituted indole-3-carboxaldehyde with indolinone in ethanol-water in presence of NaOH (1.5 mmol).

The synthetic route of 15362-40-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Shaveta; Singh, Palwinder; European Journal of Medicinal Chemistry; vol. 74; (2014); p. 440 – 450;,
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Related Products of 15362-40-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

The material 2,6-dichlorodiphenylamine (IV) (15mmol, 3.572g) was dissolved in 50ml toluene solvent and added to a three-necked flask, chloroacetyl chloride (16.5mmol, 1.8637g) was added dropwise, heated to 120 , Stir the reaction for 3h,TLC detected that the reaction of 2,6-dichlorodiphenylamine (IV) was completed and cooled to room temperature. [Et3NH]Cl-AlCl3 (30mmol, 8.129g) was slowly added dropwise to the reaction solution, stirred at room temperature for 30min, the oil bath was heated to 60C, and the reaction was stirred for 4h.TLC monitoring until the N-phenyl-N-(2,6-dichlorophenyl)chloroacetamide (III) intermediate disappeared, the reaction solution was slowly poured into a separatory funnel, allowed to stand for separation, and the ions were separated The liquid is recovered and applied. The application effect is shown in Table 1. The organic layer is added dropwise with 10% NaOH (30mmol, 1.2g) and heated to reflux for 2h.TLC monitors the completion of the reaction of 1-(2,6-dichlorophenyl)-2-indoline (II) intermediate, separates and removes the organic layer, evaporates part of the water from the water layer under reduced pressure, cools and crystallizes, Recrystallized with water,4.035g of white solid was obtained with a yield of 84.56%,The HPLC content is 99.85%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(2,6-Dichlorophenyl)-2-indolinone, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhejiang University of Technology; Luo Shuping; Xu Dandan; Ren Chenchao; Wang Tianqi; (6 pag.)CN111116391; (2020); A;,
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