In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 153072-43-6 as follows. Recommanded Product: Methyl 2,3-dioxoindoline-4-carboxylate
To a chloroform solution (9 ml) of methyl 2,3-dioxo-2,3-dihydro-1H-indole-4-carboxylate (726 mg, 3.54 mmol), N,N-diethylaminosulfur trifluoride (1.16 ml, 8.85 mmol) was added and the resulting mixture was stirred at room temperature for an hour. To the reaction mixture, a saturated aqueous solution of sodium hydrogencarbonate was added under cooling with ice to arrest the reaction and after rendering the mixture acidic with a saturated aqueous solution of ammonium chloride, extraction was conducted. The organic layer was dried and then concentrated under reduced pressure. The resulting residue was purified with a silica gel cartridge (hexane/ethyl acetate=60:40 to 0:100). As a result, the titled compound was obtained as a pale yellow powder in an amount of 136 mg (yield: 17%). (ESI neg.) m/z: 226 (M-H)-
According to the analysis of related databases, 153072-43-6, the application of this compound in the production field has become more and more popular.