1498-88-0 Archives - Indolines-derivatives

9/8/21 News The origin of a common compound about 1498-88-0

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1498-88-0, name is 1′,3′,3′-Trimethyl-6-nitrospiro[chromene-2,2′-indoline], This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1′,3′,3′-Trimethyl-6-nitrospiro[chromene-2,2′-indoline]

1,3,3-Trimethyl-60-nitrospiro[chromene-2,20-indoline] (6.45 g,20 mmol) and SnCl2 (18.96 g, 0.10 mol) were added to a flask underN2 atmosphere. Anhydrous ethanol (100 mL) was added and thereaction mixture was heated to reflux for 2 h. After reaction themixture was cooled to room temperature and filtered. The filtratewas concentrated and 5% aqueous NaOH was added to the residue.The organic phase was extracted with dichloromethane for threetimes,washed withwater and dried. After filtration the solvent wasremoved by evaporation and the residue was purified by columnchromatography with petroleum ether/ethyl acetate (3:1, v/v) aseluent to give the reduction product 1,3,3-trimethyl-60-aminospiro[chromene-2,20-indoline] (3.18 g) as brown solid in 54% yield. Mp139e140 C. 1H NMR (400 MHz, CDCl3) d 7.16e7.14 (m, 1H), 7.05 (d,J 8.3 Hz, 1H), 6.81e6.79 (m, 1H), 6.74 (d, J 8.8 Hz, 1H), 6.55e6.44(m, 3H), 6.41 (d, J 7.9 Hz, 1H), 5.67 (d, J 10.9 Hz, 1H), 2.85 (s, 3H),1.45 (s, 3H), 1.30 (s, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Zhang, Ruiqing; Hu, Luping; Xu, Zhenxiang; Song, Yanxi; Li, Hongqi; Zhang, Xin; Gao, Xucheng; Wang, Mengxuan; Xian, Chunying; Journal of Molecular Structure; vol. 1204; (2020);,
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The important role of 1498-88-0

1498-88-0, name is 1′,3′,3′-Trimethyl-6-nitrospiro[chromene-2,2′-indoline], belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 1′,3′,3′-Trimethyl-6-nitrospiro[chromene-2,2′-indoline]

General procedure: Trifluoroacetic acid (13.9 mmol) was added to a solution of the corresponding hybrid compound 1a-c (13.9 mmol) in toluene (10 ml). For neutralization of acid the equimolar quantity of triethylamine was added. Spectrophotometric measurements for solutions were carried out on an Agilent Cary 60 Bio spectrophotometer in a KU-1 quartz cell with optical path length of 2 mm. The isomerization was investigated at room temperature for 0.2 mm solutions of 1a-c.

The synthetic route of 1498-88-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Tuktarov, Airat R.; Khuzin, Artur A.; Dzhemilev, Usein M.; Mendeleev Communications; vol. 29; 2; (2019); p. 229 – 231;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

The important role of 1′,3′,3′-Trimethyl-6-nitrospiro[chromene-2,2′-indoline]

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1498-88-0, name is 1′,3′,3′-Trimethyl-6-nitrospiro[chromene-2,2′-indoline], A new synthetic method of this compound is introduced below., Quality Control of 1′,3′,3′-Trimethyl-6-nitrospiro[chromene-2,2′-indoline]

Introduction of a new synthetic route about 1′,3′,3′-Trimethyl-6-nitrospiro[chromene-2,2′-indoline]

The synthetic route of 1498-88-0 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1498-88-0, name is 1′,3′,3′-Trimethyl-6-nitrospiro[chromene-2,2′-indoline] belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C19H18N2O3

General procedure: All spectroscopic analyses were performed with an Ocean OpticsUSB 4000 spectrometer and an LS-1 tungsten halogen lamp with a400 nm longpass filter. UV and visible light exposures were performedusing a UV-UVP lamp (4 Watt, 365 nm) and a Fisher ScientificUltra-bright LED Illuminator (18 mW, 400e750 nm)respectively. All spectroscopic analyses were carried out withconstant magnetic stirring at room temperature. Monomer solution spectra were measured using a quartz cuvette containing a 1 mLaliquot of a 1 103 M monomer solution in acetone. Polymerspectra were obtained by suspending a 5 mg quantity of polymer in2 mL of acetone in a 1 cm quartz cuvette. Absorbance spectra of theMC forms of dyes were recorded after exposure to UV light for1 min. The metal complex spectra were obtained by adding a 20 mLaliquot of a 0.02 M CoCl2 or ZnCl2 solution in acetone to the cuvetteafter 1 min of UV light exposure, and then recording the spectrum.Experiments to measure the rates of photochemical isomerizationfrom the SP to MC form (forward reaction) were conducted underconstant UV light, with absorbance measurements recorded at thewavelength of maximum absorbance (lmax) every 10 s for a total of10 min. To determine the rate of isomerization from the MC to SPform (reverse reaction), the cuvette was first exposed to UV light(solution 45 s; polymer 8 min) to convert the dye to the MCform. The reverse reaction was then monitored during constantvisible light exposure, with absorbance measurements recorded atlmax every 10 s for total of 15 min.

The synthetic route of 1498-88-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sennett, Kelly A.; Lindner, Brian K.; Kaur, Navdeep; Fetner, Shannon M.; Stitzel, Shannon E.; Dyes and Pigments; vol. 98; 3; (2013); p. 437 – 441;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem